| Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior. | Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior.
Zamanirad F, Eskandari K, Mousavi Z, Haghparast A. | 12/21/2023 |
| Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats. | Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats.
Nazari-Serenjeh F, Azizbeigi R, Rashvand M, Mesgar S, Amirteymori H, Haghparast A. | 12/31/2022 |
| Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain. | Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain.
Zareie F, Ghalebandi S, Askari K, Mousavi Z, Haghparast A. | 03/26/2022 |
| The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats. | The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats.
Abounoori M, Maddah MM, Akbari E, Houshmand G, Ardeshiri MR. | 02/20/2021 |
| Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus. | Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus.
Dai YE, Lee YH, Li TL, Hwang LL. | 10/24/2020 |
| Orexin A-induced hyperlocomotion is mainly mediated by the activation of the OX2 receptor. | Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats.
Maehara S, Furukawa J, Ota T. | 05/2/2020 |
| Study shows that hippocampal orexin receptor (OXRs) blocking prevented the stress induced social learning and memory deficits. Study identifies hippocampal OXRs as potential candidates capable of preventing acute stress-induced impairments of social novelty and anxiety behavior. | Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits.
Bahramzadeh Zoeram S, Elahdadi Salmani M, Lashkarbolouki T, Goudarzi I. | 11/30/2019 |
| The authors concluded that in spontaneously hypertensive rats, orexin neurons in the dorsomedial hypothalamus might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-rostral ventrolateral medulla pathway. | Role of the orexin 2 receptor in palatable-food consumption-associated cardiovascular reactivity in spontaneously hypertensive rats.
Huang SC, Li TL, Lee YH, Dai YE, Chen YC, Hwang LL., Free PMC Article | 10/26/2019 |
| Results showed that the blockade of Ox1r and Ox2r in the nucleus accumbens (NAc) attenuated the effect of food deprivation (FD) on morphine reinstatement; however, they were more effective in FD condition. Findings indicate that the NAc is a brain area within which orexin has a fundamental role in the effect of stress on morphine-induced reinstatement and the effect of food deprivation- on the reinstatement of morphine. | Role of the orexin receptors within the nucleus accumbens in the drug priming-induced reinstatement of morphine seeking in the food deprived rats.
Sahafzadeh M, Karimi-Haghighi S, Mousavi Z, Haghparast A. | 09/1/2018 |
| Results suggest that both orexin-1 and -2 receptors in the nucleus accumbens are involved in the development of morphine-induced conditioned place preference. It seems that orexin-1 receptors in this region are more effective in development of drug seeking behaviors in the rats. | Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats.
Alizamini MM, Farzinpour Z, Ezzatpanah S, Haghparast A. | 06/16/2018 |
| Study suggests that orexins, via activation of both orexin receptor type 1 and orexin receptor type 2, play a significant role in the expression of NMDA-dependent long-term depression, thereby contributing to the spinal modulation of pain transmission. | Orexin receptors mediate long-term depression of excitatory synaptic transmission in the spinal cord dorsal horn.
Park KB, Weon H. | 06/16/2018 |
| Results showed that the postsynaptic modulations of orexin on gigantocellular reticular nucleus reticulospinal neurons were mediated by both orexin-1 and orexin-2 receptors. | Orexin exerts excitatory effects on reticulospinal neurons in the rat gigantocellular reticular nucleus through the activation of postsynaptic orexin-1 and orexin-2 receptors.
Yang N, Wang GZ, Wen SY, Qiao QC, Liu YH, Zhang J. | 05/5/2018 |
| Study suggests that the orexin-1 and orexin-2 receptor mediated projections from the lateral hypothalamus to dentate gyrus are involved in the development, expression and extinction of conditioned place preference induced by lateral hypothalamus stimulation | Involvement of orexin-1 and orexin-2 receptors within the dentate gyrus of the hippocampus in the acquisition, expression and extinction of lateral hypothalamic-induced conditioned place preference in the rats.
Parsania S, Moradi M, Fatahi Z, Haghparast A. | 07/8/2017 |
| Study using specific orexin receptor antagonists suggests that the orexin 2 receptor has a dominant role in the observed effects of orexin A/hypocretin-1 . To our knowledge, this article is the first to show orexinergic modulation of the ventrolateral geniculate nucleus . | Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.
Chrobok L, Palus K, Lewandowski MH. | 12/17/2016 |
| the OX2 receptor has a critical role in modulating reward circuit in the Ventral Tegmental Area and Nucleus Accumbens | Functional interaction between OX2 and CB1 receptors in the ventral tegmental area and the nucleus accumbens in response to place preference induced by chemical stimulation of the lateral hypothalamus.
Yazdi F, Jahangirvand M, Pirasteh AH, Moradi M, Haghparast A. | 09/24/2016 |
| Activation of orexin perifornical hypothalamus-rostral ventrolateral medulla (RVLM) neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia. | Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia: Involvement of Orexin Type 2 (OX2-R) Receptors.
Korim WS, Llewellyn-Smith IJ, Verberne AJ. | 06/28/2016 |
| Study reveals a direct excitatory action of orexin on inferior vestibular nucleus neurons via co-activation of both postsynaptic OX1 and OX2 receptors | Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors.
Yu L, Zhang XY, Chen ZP, Zhuang QX, Zhu JN, Wang JJ. | 02/27/2016 |
| Orexin 2 receptor (and orexin 1 receptor) contribute to the cardiovascular and locomotor response to stress. | Both Ox1r and Ox2r orexin receptors contribute to the cardiovascular and locomotor components of the novelty stress response in the rat.
Beig MI, Dampney BW, Carrive P. | 07/25/2015 |
| Orexins modifiy orexin receptor gene expression and gonadotropin release from the anterior pituitary gland. | Orexin A and B in vitro modify orexins receptors expression and gonadotropins secretion of anterior pituitary cells of proestrous rats.
Cataldi NI, Lux Lantos VA, Libertun C. | 10/25/2014 |
| Elevated OX2R-mediated activity in the brain. | Blockade of central orexin 2 receptors reduces arterial pressure in spontaneously hypertensive rats.
Lee YH, Dai YW, Huang SC, Li TL, Hwang LL. | 05/3/2014 |
| Suggest a more prominent role for OX(2)R in ethanol self-administration compared to cue-conditioned ethanol-seeking. | Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
Brown RM, Khoo SY, Lawrence AJ. | 04/5/2014 |
| The results indicate that in cultured rat cortical neurons orexin receptors are also coupled to inositol phosphates signaling pathway. | Orexins/hypocretins stimulate accumulation of inositol phosphate in primary cultures of rat cortical neurons.
Zawilska JB, Urbańska A, Sokołowska P. | 02/8/2014 |
| siRNA knockdown of OX2R in pontomesencephalic tegmentum increases duration of REM episodes. | Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep.
Chen L, McKenna JT, Bolortuya Y, Brown RE, McCarley RW., Free PMC Article | 08/31/2013 |
| OX2R protein and mRNA are expressed in C6 glioma cells. | Orexin A suppresses the growth of rat C6 glioma cells via a caspase-dependent mechanism.
Biegańska K, Sokołowska P, Jöhren O, Zawilska JB., Free PMC Article | 04/20/2013 |
| In cultured rat cortical neurons, acting at OX2 receptors coupled to Gi protein, orexin inhibits cyclic AMP synthesis. | Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures.
Urbańska A, Sokołowska P, Woldan-Tambor A, Biegańska K, Brix B, Jöhren O, Namiecińska M, Zawilska JB., Free PMC Article | 01/26/2013 |