| Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. | Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment.
Xu P, Xu X, Liu J, Hu H, Shen H, Chen C. | 04/23/2022 |
| Association study of performance-related polymorphisms in Brazilian combat-sport athletes highlights variants in the GABPB1 gene. | Association study of performance-related polymorphisms in Brazilian combat-sport athletes highlights variants in the GABPB1 gene.
Guilherme JPLF, Souza-Junior TP, Lancha Junior AH. | 12/11/2021 |
| Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage. | Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage.
Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF., Free PMC Article | 10/23/2021 |
| FGFR4 promotes nuclear localization of GABP to inhibit cell apoptosis in uterine leiomyosarcoma. | FGFR4 promotes nuclear localization of GABP to inhibit cell apoptosis in uterine leiomyosarcoma.
Zhang P, Zhang H, Wang Y. | 09/25/2021 |
| LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. | LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells.
Qi W, Li Z, Xia L, Dai J, Zhang Q, Wu C, Xu S., Free PMC Article | 10/31/2020 |
| G allele of (rs7181866 A/G) was found to be significantly associated with risk for obesity among T2DM subjects | Association of SNP rs7181866 in the nuclear respiratory factor-2 beta subunit encoding GABPB1 gene with obesity and type-2 diabetes mellitus in South Indian population.
Umapathy D, Balashanmugam P, Vanniya Subramanyam P, Rajan T, Natarajan P, Krishnamoorthy E, Viswanathan V, Kunka Mohanram R. | 11/9/2019 |
| Study in glioblastoma cells shows that genetic disruption of GABPbeta1L (beta1L), a tetramer-forming isoform of GABP that is dispensable for normal development, results in TERT silencing in a TERT promoter mutation-dependent manner. Reducing TERT expression by disrupting beta1L culminates in telomere loss and cell death exclusively in TERT promoter mutant cells. | Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF., Free PMC Article | 06/29/2019 |
| Data revealed high expression of GABPB1 in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. Its knockdown significantly decreased the colony formation ability via induction of p21Waf/Cip1 expression. Furthermore, the patients at high risk of a poor survival outcome exhibited the highest expression level of GABPB1. These findings imply that GABPB1 serves an important role in the progression of ccRCC. | Knockdown of GA-binding protein subunit β1 inhibits cell proliferation via p21 induction in renal cell carcinoma.
Chen SC, Yen MC, Chen FW, Wu LY, Yang SJ, Kuo PL, Hsu YL. | 10/27/2018 |
| Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells. | GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia.
Manukjan G, Ripperger T, Venturini L, Stadler M, Göhring G, Schambach A, Schlegelberger B, Steinemann D. | 11/4/2017 |
| role for GABPA/B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly recurrent promoter mutations in melanoma. | SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.
Zhang T, Xu M, Makowski MM, Lee C, Kovacs M, Fang J, Willems E, Trent JM, Hayward NK, Vermeulen M, Brown KM., Free PMC Article | 08/12/2017 |
| GABP beta is required for YAP expression in vitro and in vivo, and that YAP is an important effector downstream of GABP for cell survival and cell-cycle progression. | The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D., Free PMC Article | 12/21/2013 |
| The NRF-2beta nuclear localization signal (NLS) is an unusual but is, nevertheless, a bona fide monopartite-type NLS. | Nuclear Respiratory Factor 2β (NRF-2β) recruits NRF-2α to the nucleus by binding to importin-α:β via an unusual monopartite-type nuclear localization signal.
Hayashi R, Takeuchi N, Ueda T. | 12/14/2013 |
| NRF-1 and GABP expression is coordinated by NRF-1's activation of the GABPbeta promoter | Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex.
Thompson C, MacDonald G, Mueller CR., Free PMC Article | 09/24/2011 |
| Data show that BRAF knockdown led to suppression of the expression of the GABPbeta, which involved in regulating HPR1 promoter activity. | Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.
Rao G, Liu D, Xing M, Tauler J, Prinz RA, Xu X., Free PMC Article | 03/12/2011 |
| The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.[NRF-2beta] | PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression.
Vercauteren K, Gleyzer N, Scarpulla RC., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesInteraction between SNPs in the NRF2 gene and elite endurance performance.
Eynon N, Alves AJ, Sagiv M, Yamin C, Sagiv M, Meckel Y. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. NRF2 genotype improves endurance capacity in response to training.
He Z, Hu Y, Feng L, Lu Y, Liu G, Xi Y, Wen L, McNaughton LR. | 03/13/2008 |
| serum-responsive GABP binding to Ets-binding sites activates the KIS promoter, leading to KIS gene expression, cell migration, and cell cycle progression | GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression.
Crook MF, Olive M, Xue HH, Langenickel TH, Boehm M, Leonard WJ, Nabel EG. | 01/21/2010 |
| Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia [GA-binding protein gamma]. | Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor.
Jeong BC, Kim MY, Lee JH, Kee HJ, Kho DH, Han KE, Qian YR, Kim JK, Kim KK. | 01/21/2010 |
| Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. | Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency.
Marie S, Race V, Nassogne MC, Vincent MF, Van den Berghe G., Free PMC Article | 01/21/2010 |
| The cyrstal structure of a ternary complex containing the mouse GA binding protein transcription factor, beta subunit 2, was resolved at 2.15 angstrom resolution. | The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA.
Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C. | 05/27/2003 |