| Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients. | Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients.
Santoni G, Amantini C, Nabissi M, Arcella A, Maggi F, Santoni M, Morelli MB., Free PMC Article | 02/26/2022 |
| Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway. | Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway.
Yu H, Xie M, Meng Z, Lo CY, Chan FL, Jiang L, Meng X, Yao X., Free PMC Article | 12/18/2021 |
| The acidic TRPML2 extracytosolic/lumenal domain (ELD) pre-pore loop exhibits a pH-dependent Ca2+ interaction, suggesting a mechanism for channel activity regulation in the endolysosomal system. | Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.
Viet KK, Wagner A, Schwickert K, Hellwig N, Brennich M, Bader N, Schirmeister T, Morgner N, Schindelin H, Hellmich UA. | 05/9/2020 |
| The authors show that MCOLN2 specifically promotes viral vesicular trafficking and subsequent escape from endosomal compartments. This mechanism requires channel activity, occurs independently of antiviral signaling, and broadly applies to enveloped RNA viruses that require transport to late endosomes for infection, including influenza A virus, yellow fever virus, and Zika virus. | Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses.
Rinkenberger N, Schoggins JW., Free PMC Article | 01/12/2019 |
| High TRPML-2 expression in glioma cells resulted in increased survival and proliferation signaling, suggesting a pro-tumorigenic role played by TRPML-2 in glioma progression. | Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression.
Morelli MB, Nabissi M, Amantini C, Tomassoni D, Rossi F, Cardinali C, Santoni M, Arcella A, Oliva MA, Santoni A, Polidori C, Mariani MP, Santoni G., Free PMC Article | 12/30/2017 |
| MCOLN2 is transcriptionally activated by PAX5 and has roles in B cell development and function | PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene.
Valadez JA, Cuajungco MP., Free PMC Article | 02/21/2015 |
| TRPML2 is activated by lowering the extracellular sodium concentration as well as by a subset of small chemical compounds that were previously identified as activators of TRPML3. | Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.
Grimm C, Jörs S, Guo Z, Obukhov AG, Heller S., Free PMC Article | 09/15/2012 |
| TRPML 1, 2 and 3 assemblies regulated cell viability and starvation-induced autophagy. | Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy.
Zeevi DA, Lev S, Frumkin A, Minke B, Bach G., Free PMC Article | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| constitutively active h-TRPML2 leads to cell death by causing Ca(2+) overload | Constitutive activity of the human TRPML2 channel induces cell degeneration.
Lev S, Zeevi DA, Frumkin A, Offen-Glasner V, Bach G, Minke B., Free PMC Article | 03/1/2010 |
| TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2. | The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1.
Samie MA, Grimm C, Evans JA, Curcio-Morelli C, Heller S, Slaugenhaupt SA, Cuajungco MP., Free PMC Article | 01/21/2010 |
| Data show that TRPMLs form distinct functional channel complexes. | Functional multimerization of mucolipin channel proteins.
Curcio-Morelli C, Zhang P, Venugopal B, Charles FA, Browning MF, Cantiello HF, Slaugenhaupt SA. | 01/21/2010 |
| MCOLN2 traffics through the ADP-ribosylation factor 6 (Arf6)-associated pathway, colocalizing with major histocompatibility protein class I and CD59 in long recycling endosomes. | Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs.
Karacsonyi C, Miguel AS, Puertollano R. | 01/21/2010 |
| there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa | Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.
Venkatachalam K, Hofmann T, Montell C., Free PMC Article | 01/21/2010 |