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    YTHDF3 YTH N6-methyladenosine RNA binding protein F3 [ Homo sapiens (human) ]

    Gene ID: 253943, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    YTHDF3 Regulates the Degradation and Stability of m6A-Enriched Transcripts to Facilitate the Progression of Castration-Resistant Prostate Cancer.

    YTHDF3 Regulates the Degradation and Stability of m6A-Enriched Transcripts to Facilitate the Progression of Castration-Resistant Prostate Cancer.
    Duan J, Fan D, Chen P, Xiang J, Xie X, Peng Y, Bai J, Li T, Li Y, Song H, Fu W, Zhang T, Xiao Y, Qi X, Hong W, Zhou J, He Y, Wu C, Zeng H, Bai H, Chen T, Yu W, Zhang Q.

    09/20/2024
    The m[6]A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation.

    The m(6)A reading protein YTHDF3 potentiates tumorigenicity of cancer stem-like cells in ocular melanoma through facilitating CTNNB1 translation.
    Xu Y, He X, Wang S, Sun B, Jia R, Chai P, Li F, Yang Y, Ge S, Jia R, Yang YG, Fan X.

    07/29/2024
    Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus Inhibit Bladder Cancer Stem Cell Stemness.

    Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus Inhibit Bladder Cancer Stem Cell Stemness.
    Qiu D, Gao L, Yu X.

    07/26/2024
    ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.

    ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
    Zhang H, Sun Y, Wang Z, Huang X, Tang L, Jiang K, Jin X., Free PMC Article

    07/5/2024
    The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.

    The inhibition of YTHDF3/m(6)A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.
    Zhong S, Guo Q, Chen X, Luo X, Long Y, Chong T, Ye M, He H, Lu A, Ao K, Yin M, Xu A, Li X, Hao Y, Guo X., Free PMC Article

    02/16/2024
    YTHDF3 Modulates EGFR/ATK/ERK/p21 Signaling Axis to Promote Cancer Progression and Osimertinib Resistance of Glioblastoma Cells.

    YTHDF3 Modulates EGFR/ATK/ERK/p21 Signaling Axis to Promote Cancer Progression and Osimertinib Resistance of Glioblastoma Cells.
    Lee HH, Hsieh CC, Chang CC, Liao WT, Chi HC.

    12/4/2023
    m[6] A reader YTHDF3 triggers the progression of hepatocellular carcinoma through the YTHDF3/m[6] A-EGFR/STAT3 axis and EMT.

    m(6) A reader YTHDF3 triggers the progression of hepatocellular carcinoma through the YTHDF3/m(6) A-EGFR/STAT3 axis and EMT.
    Hu B, Gao J, Shi J, Wen P, Guo W, Zhang S.

    09/23/2023
    N[6]-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability.

    N(6)-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability.
    Liu D, Li Z, Zhang K, Lu D, Zhou D, Meng Y.

    07/20/2023
    m[6]A reader YTHDF3 is associated with clinical prognosis, related RNA signatures and immunosuppression in gastric cancer.

    m(6)A reader YTHDF3 is associated with clinical prognosis, related RNA signatures and immunosuppression in gastric cancer.
    Yu Y, Meng LL, Chen XY, Fan HN, Chen M, Zhang J, Zhu JS.

    06/15/2023
    YTHDF3 mediates HNF1alpha regulation of cervical cancer radio-resistance by promoting RAD51D translation in an m6A-dependent manner.

    YTHDF3 mediates HNF1α regulation of cervical cancer radio-resistance by promoting RAD51D translation in an m6A-dependent manner.
    Du H, Zou NY, Zuo HL, Zhang XY, Zhu SC.

    04/7/2023
    YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.

    YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
    Zhao Y, Zhao H, Zhang D, Quan Q, Ge Y, Li L, Guo L.

    07/23/2022
    N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-kappaB pathways.

    N6-methyladenosine reader YTH N6-methyladenosine RNA binding protein 3 or insulin like growth factor 2 mRNA binding protein 2 knockdown protects human bronchial epithelial cells from hypoxia/reoxygenation injury by inactivating p38 MAPK, AKT, ERK1/2, and NF-κB pathways.
    Xiao K, Liu P, Yan P, Liu Y, Song L, Liu Y, Xie L., Free PMC Article

    05/28/2022
    Mono-allelic loss of YTHDF3 and neurodevelopmental disorder: clinical features of four individuals with 8q12.3 deletions.

    Mono-allelic loss of YTHDF3 and neurodevelopmental disorder: clinical features of four individuals with 8q12.3 deletions.
    Terkelsen T, Brasch-Andersen C, Illum N, Busa T, Missirian C, Chandler K, Holden ST, Jensen UB, Fagerberg CR.

    04/2/2022
    Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.

    Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.
    Hu K, Yao L, Yan Y, Zhou L, Li J., Free PMC Article

    01/22/2022
    Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.

    Enterovirus 2A(pro) Cleavage of the YTHDF m(6)A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.
    Kastan JP, Tremblay MW, Brown MC, Trimarco JD, Dobrikova EY, Dobrikov MI, Gromeier M., Free PMC Article

    10/9/2021
    Development and validation of m6A regulators' prognostic significance for endometrial cancer.

    Development and validation of m6A regulators' prognostic significance for endometrial cancer.
    Pang X, Zhang X, Huang Y, Qian S., Free PMC Article

    07/10/2021
    YTHDF3 Induces the Translation of m(6)A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.

    YTHDF3 Induces the Translation of m(6)A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.
    Chang G, Shi L, Ye Y, Shi H, Zeng L, Tiwary S, Huse JT, Huo L, Ma L, Ma Y, Zhang S, Zhu J, Xie V, Li P, Han L, He C, Huang S., Free PMC Article

    05/29/2021
    YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

    YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
    Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J.

    05/29/2021
    m(6)A-binding YTHDF proteins promote stress granule formation.

    m(6)A-binding YTHDF proteins promote stress granule formation.
    Fu Y, Zhuang X., Free PMC Article

    11/21/2020
    Abundance of N-6-methyladenosine and expression of VIRMA/YTHDF3 were different among testicular germ cell tumors subtypes, with higher levels in seminomas (SEs), suggesting a contribution to SE phenotype maintenance.

    m(6)A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance.
    Lobo J, Costa AL, Cantante M, Guimarães R, Lopes P, Antunes L, Braga I, Oliveira J, Pelizzola M, Henrique R, Jerónimo C., Free PMC Article

    04/25/2020
    These results indicate that together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of N(6)-methyladenosine -modified mRNAs in the cytoplasm.

    YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
    Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C., Free PMC Article

    12/16/2017
    The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription, while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover, silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells, while silencing the N(6)-methyladenosine erasers increased Gag expression.

    N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
    Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L., Free PMC Article

    12/2/2017
    Includes a multi-species analysis of YTHDF family members.

    Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates.
    Sundström G, Dreborg S, Larhammar D., Free PMC Article

    04/22/2013
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