| FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population. | FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population.
Li M, Qiao R, Zhong R, Wei Y, Wang J, Zhang Z, Wang L, Xu T, Wang Y, Dai L, Gu W, Han B, Yang R. | 06/18/2022 |
| The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. | The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.
Dadwal N, Mix C, Reinhold A, Witte A, Freund C, Schraven B, Kliche S., Free PMC Article | 12/18/2021 |
| Findings reveal that ADAP acts upstream of SLP-76 to convert labile, Ca(2+)-competent microclusters into stable adhesive junctions with enhanced signaling potential. | ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.
Lewis JB, Scangarello FA, Murphy JM, Eidell KP, Sodipo MO, Ophir MJ, Sargeant R, Seminario MC, Bunnell SC., Free PMC Article | 01/11/2020 |
| results of this study indicate that a novel T cell adaptor protein, activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP), plays a unique role in T cells as a part of both the proximal activation signaling and inside-out signaling pathways that result in integrin activation and T cell adhesion | ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion.
Jung SH, Yoo EH, Yu MJ, Song HM, Kang HY, Cho JY, Lee JR. | 06/8/2018 |
| Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL and for activation of the small GTPase Rac1 in T cell adhesion. | Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
Xiong Y, Ye C, Yang N, Li M, Liu H. | 12/30/2017 |
| Current knowledge of the functions of the adapter protein ADAP in T cell signaling with a focus on the role of individual phosphotyrosine (pY) motifs for SH2 domain mediated interactions is presented. | Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.
Kuropka B, Schraven B, Kliche S, Krause E, Freund C. | 10/7/2017 |
| A distinct set of proteins interaction partners required for chemokine-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70. | Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.
Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C., Free PMC Article | 08/13/2016 |
| Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation. | Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1.
Dios-Esponera A, Isern de Val S, Sevilla-Movilla S, García-Verdugo R, García-Bernal D, Arellano-Sánchez N, Cabañas C, Teixidó J., Free PMC Article | 07/2/2016 |
| FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency. | Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.
Levin C, Koren A, Pretorius E, Rosenberg N, Shenkman B, Hauschner H, Zalman L, Khayat M, Salama I, Elpeleg O, Shalev S. | 04/30/2016 |
| Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 production and TGFbeta1-induced CD103 expression in CD8+ T-lymphocytes and protects against influenza H5N1 virus infection. | The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
Li C, Jiao S, Wang G, Gao Y, Liu C, He X, Zhang C, Xiao J, Li W, Zhang G, Wei B, Chen H, Wang H., Free PMC Article | 04/2/2016 |
| The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset. | Short Communication FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III.
Addobbati CJ, de Azevêdo Silva J, Tavares NA, Araújo J, Guimarães RL, Brandão L, Crovella S, Sandrin-Garcia P. | 01/23/2016 |
| The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene. | Recessive thrombocytopenia likely due to a homozygous pathogenic variant in the FYB gene: case report.
Hamamy H, Makrythanasis P, Al-Allawi N, Muhsin AA, Antonarakis SE., Free PMC Article | 07/4/2015 |
| ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. | ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ., Free PMC Article | 07/19/2014 |
| ADAP and Nck adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 ligand ICAM-1. | The adapter proteins ADAP and Nck cooperate in T cell adhesion.
Lettau M, Kliche S, Kabelitz D, Janssen O. | 07/12/2014 |
| These findings indicate that ADAP regulates two steps of HIV-1 infection cooperatively with two distinct receptors, and as such, serves as a new potential target in the blockade of HIV-1 infection. | Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors.
Wei B, Han L, Abbink TE, Groppelli E, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H, Rudd CE., Free PMC Article | 07/12/2014 |
| our findings indicate an association between polymorphisms located in FYB gene and SLE, suggesting their possible involvement in disease susceptibility and clinical manifestations. | FYB gene polymorphisms are associated with susceptibility for systemic lupus erythemathosus (SLE).
Addobbati C, Brandão LA, Guimarães RL, Pancotto JA, Donadi EA, Crovella S, Segat L, Sandrin-Garcia P. | 01/25/2014 |
| Multipoint binding of SLP-76 to ADAP facilitates the assembly of SLP-76 microclusters. | Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.
Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE., Free PMC Article | 12/14/2013 |
| TM4SF10, possibly through ADAP, may regulate Fyn activity | TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Azhibekov TA, Wu Z, Padiyar A, Bruggeman LA, Simske JS., Free PMC Article | 01/21/2012 |
| a functional cooperation between Nck and ADAP in stabilizing the recruitment of WASp to SLP76 regulates actin rearrangement. | Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.
Pauker MH, Reicher B, Fried S, Perl O, Barda-Saad M., Free PMC Article | 08/27/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation | NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.
Srivastava R, Burbach BJ, Shimizu Y., Free PMC Article | 05/10/2010 |
| Mass spectrometric identification of ADAP associated with EVL, an actin-binding protein of the ENA/VASP family, DOCK2 and GEF-H1 suggests a direct link between ADAP and the cytoskeleton. | A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein.
Lehmann R, Meyer J, Schuemann M, Krause E, Freund C. | 02/22/2010 |
| Naive transgenic ADAP-deficient T cells show impaired adhesion to ovalbumin fragment-bearing antigen-presenting cells that is restored following reconstitution with wild-type ADAP. | Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.
Burbach BJ, Srivastava R, Medeiros RB, O'Gorman WE, Peterson EJ, Shimizu Y., Free PMC Article | 01/21/2010 |
| ADAP-deficient T-cell-receptor transgenic T cells demonstrate that ADAP is a positive regulator of antigen-dependent, LFA-1 integrin-mediated T cell conjugate formation with antigen presenting cells. | Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival.
Mueller KL, Thomas MS, Burbach BJ, Peterson EJ, Shimizu Y. | 01/21/2010 |
| An eight-membered ring formed upon oxidation of two neighboring cysteines leads to significant changes in the variable arginine-threonine (RT) loop of the hSH3N domain of this protein. | Redox-regulated conformational changes in an SH3 domain.
Zimmermann J, Kühne R, Sylvester M, Freund C. | 01/21/2010 |