| Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis. | Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.
Taglietti V, Kefi K, Bronisz-Budzyńska I, Mirciloglu B, Rodrigues M, Cardone N, Coulpier F, Periou B, Gentil C, Goddard M, Authier FJ, Pietri-Rouxel F, Malfatti E, Lafuste P, Tiret L, Relaix F., Free PMC Article | 04/30/2022 |
| A Study on COMP and CTX-II as Molecular Markers for the Diagnosis of Intervertebral Disc Degeneration. | A Study on COMP and CTX-II as Molecular Markers for the Diagnosis of Intervertebral Disc Degeneration.
Qi DD, Liu ZH, Wu DS, Huang YF., Free PMC Article | 10/2/2021 |
| COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation. | COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W., Free PMC Article | 12/7/2019 |
| COMP could normally have a protective role against PASMC phenotype switching | Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells.
Yu H, Jia Q, Feng X, Chen H, Wang L, Ni X, Kong W. | 11/18/2017 |
| these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence. | Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.
Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W. | 06/3/2017 |
| COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways | COMP-angiopoietin 1 increases proliferation, differentiation, and migration of stem-like cells through Tie-2-mediated activation of p38 MAPK and PI3K/Akt signal transduction pathways.
Kook SH, Lim SS, Cho ES, Lee YH, Han SK, Lee KY, Kwon J, Hwang JW, Bae CH, Seo YK, Lee JC. | 02/14/2015 |
| results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age | COMP-Ang1 inhibits apoptosis as well as improves the attenuated osteogenic differentiation of mesenchymal stem cells induced by advanced glycation end products.
Kim S, Kwon J. | 11/2/2013 |
| The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis. | D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.
Coustry F, Posey KL, Liu P, Alcorn JL, Hecht JT., Free PMC Article | 03/31/2012 |
| Cartilage oligomeric matrix protein is a novel inhibitor of vascular smooth muscle calcification. | Cartilage oligomeric matrix protein inhibits vascular smooth muscle calcification by interacting with bone morphogenetic protein-2.
Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu CJ, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W, Wang X. | 06/18/2011 |
| Overexpression of COMP markedly suppressed PDGF-BB-elicited VSMC dedifferentiation. Alpha(7)beta(1) integrin is a potential receptor for COMP. | Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.
Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu CJ, Zhu Y, Gao Y, Xu Q, Kong W, Wang X. | 04/12/2010 |
| To identify residues critical for the structure, stability, oligomerization and binding to vitamin D as well as two small molecules, all-trans-retinol and curcumin, an alanine-scanning mutagenesis study of cartilage oligomeric matrix protein is performed. | N-terminal aliphatic residues dictate the structure, stability, assembly, and small molecule binding of the coiled-coil region of cartilage oligomeric matrix protein.
Gunasekar SK, Asnani M, Limbad C, Haghpanah JS, Hom W, Barra H, Nanda S, Lu M, Montclare JK. | 01/21/2010 |
| ultrastructural distribution of COMP & TSP-4 & collagen fibril thickness in achilles tendon related to exercise; COMP immunolabeling decreased with longer running distance & was lower in pericellular & interterritorial compartments of high training rats | Ultrastructural immunolocalization of cartilage oligomeric matrix protein, thrombospondin-4, and collagen fibril size in rodent achilles tendon in relation to exercise.
Södersten F, Ekman S, Niehoff A, Zaucke F, Heinegård D, Hultenby K. | 01/21/2010 |
| Expression of COMP in both anulus fibrosus(AF) and nucleus pulposus(NP) of intervertebral disc(IVD). COMP is component of extracellular matrix of AF and NP, with lamellar distribution in AF. May play role in normal structure of IVD. | Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc.
Ishii Y, Thomas AO, Guo XE, Hung CT, Chen FH. | 01/21/2010 |
| COMP secretion is affected by the signal peptide | Secretion of cartilage oligomeric matrix protein is affected by the signal peptide.
Holden P, Keene DR, Lunstrum GP, Bächinger HP, Horton WA. | 01/21/2010 |
| Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin. | Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.
Di Cesare PE, Chen FS, Moergelin M, Carlson CS, Leslie MP, Perris R, Fang C. | 01/21/2010 |
| COMP has a role in development of the extracellular matrix and in a cell culture model for pseudoachondroplasia | Cell-type specific trafficking of expressed mutant COMP in a cell culture model for PSACH.
Chen TL, Stevens JW, Cole WG, Hecht JT, Vertel BM. | 01/21/2010 |
| The X-ray structure of the COMP coiled coil domain in complex with vitamin D(3) at 1.7 A resolution is reported. COMP exerts a distinct mechanism of interaction mainly defined by the pattern of hydrophobic core residues. | Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).
Ozbek S, Engel J, Stetefeld J., Free PMC Article | 01/21/2010 |