| Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer. | Identification of FUT7 hypomethylation as the blood biomarker in the prediction of early-stage lung cancer.
Qiao R, Di F, Wang J, Wei Y, Xu T, Dai L, Gu W, Han B, Yang R. | 08/28/2023 |
| Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma. | Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma.
Fang Y, Qu Y, Ji L, Sun H, Li J, Zhao Y, Liang F, Wang Z, Su J, Liu J, Dai L, Ouyang S., Free PMC Article | 12/17/2022 |
| Activation of alpha7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition. | Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition.
Wu CH, Inoue T, Nakamura Y, Uni R, Hasegawa S, Maekawa H, Sugahara M, Wada Y, Tanaka T, Nangaku M, Inagi R. | 02/12/2022 |
| Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis. | Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
Xu T, Liu J, Xia Y, Wang Z, Li X, Gao Q., Free PMC Article | 12/4/2021 |
| High FUT7 expression and CD15 are associated with lung and brain metastasis. | Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.
Jassam SA, Maherally Z, Ashkan K, Pilkington GJ, Fillmore HL., Free PMC Article | 12/21/2019 |
| the findings in this study suggest that hypomethylated CpG sites, present in four regions of the FOXP3 locus, CAMTA1 and FUT7 gene regions, can potentially be used to distinguish subsets of CD4+ T lymphocytes in both sexes. | Molecular Markers Distinguishing T Cell Subtypes With TSDR Strand-Bias Methylation.
Minskaia E, Saraiva BC, Soares MMV, Azevedo RI, Ribeiro RM, Kumar SD, Vieira AIS, Lacerda JF., Free PMC Article | 09/28/2019 |
| Knockdown of FUT7 inhibits human hepatocarcinoma cell proliferation. | α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation.
Li D, Sun H, Bai G, Wang W, Liu M, Bao Z, Li J, Liu H., Free PMC Article | 01/26/2019 |
| FUT7 silencing causes inhibition of adhesion and migration of HepG2 hepatocellular carcinoma cells in vitro. | Inhibition of adhesion and metastasis of HepG2 hepatocellular carcinoma cells in vitro by DNA aptamer against sialyl Lewis X.
Wang XK, Peng Y, Tao HR, Zhou FF, Zhang C, Su F, Wang SP, Liu Q, Xu LH, Pan XK, Xie W, Feng MH. | 03/17/2018 |
| FUT7 overexpression significantly promoted monocyte-endothelial adhesion, while FUT7 knockdown obviously inhibited IL-1beta-induced monocyte-endothelial adhesion | The α1,3-fucosyltransferase FUT7 regulates IL-1β-induced monocyte-endothelial adhesion via fucosylation of endomucin.
Zhang J, Ju N, Yang X, Chen L, Yu C. | 01/13/2018 |
| The DNA demethylation within the fut7 gene controls selectin ligand expression in humans, including the inducible topographic commitment of T cells for skin and inflamed sites. | Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.
Pink M, Ratsch BA, Mardahl M, Durek P, Polansky JK, Karl M, Baumgrass R, Wallner S, Cadenas C, Gianmoena K, Floess S, Chen W, Nordstroem K, Tierling S, Olek S, Walter J, Hamann A, Syrbe U. | 09/30/2017 |
| This study presents the first example of a distinct regulatory mechanism involving transcriptional down-regulation of Fut7 by MAPCs that could modulate the trafficking behavior of T cells in vivo. | Human multipotent adult progenitor cells transcriptionally regulate fucosyltransferase VII.
Burrows GG, Maziarz RT, Hunady K, Lehman N, Raber A, Deans RJ, Van't Hof W. | 11/22/2014 |
| After transfection of JAR cells with fucosyltransferase VII, the expression of FUT7 and sLeX synthesis were increased, and the percent adhesion of trophoblast cells to RL95-2 cell monolayer was significantly increased. | sLeX/L-selectin mediates adhesion in vitro implantation model.
Liu S, Yang X, Liu Y, Wang X, Yan Q. | 07/16/2011 |
| Overexpression of alpha1,3 FucT-VII promoted the expression of CD24 and SLe X and is associated with colorectal carcinoma metastases. | Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24.
Li W, Zhang W, Luo J, Cao A, Zhang Y, Huang D, Sheng W, Cai S, Li J. | 10/4/2010 |
| Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation. | Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation.
Zhang Y, Liu S, Liu Y, Wang Z, Wang X, Yan Q. | 01/21/2010 |
| This is the first time to report that alpha1,3FucT-VII can regulate the mRNA expression of integrin. | alpha1,3 fucosyltransferase-VII up-regulates the mRNA of alpha5 integrin and its biological function.
Wang QY, Zhang Y, Shen ZH, Chen HL. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Evaluation of urinary CA19-9 levels in bladder cancer patients classified according to the combinations of Lewis and Secretor blood group genotypes.
Nagao K, Itoh Y, Fujita K, Fujime M. | 03/13/2008 |
| The up regulation of alpha1,3FucT-VII mRNA and cell surface SLe(x) (alpha1,3FucT-VII product) by UV and down regulation of them by ATRA was speculated to be one of the mechanisms that alpha1,3FucT-VII decreased and increased [susceptibility to] apoptosis. | Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells.
Wang H, Wang QY, Zhang Y, Shen ZH, Chen HL. | 01/21/2010 |
| Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway | Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway.
Wang QY, Zhang Y, Chen HJ, Shen ZH, Chen HL. | 01/21/2010 |
| A differential functional impact of N-glycosylation on C2GnT-1 and FucT-VII and disclose that a strongly reduced FucT-VII activity retains the ability to fucosylate PSGL-1 on the core2-based binding site(s) for the three selectins. | N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.
Prorok-Hamon M, Notel F, Mathieu S, Langlet C, Fukuda M, El-Battari A., Free PMC Article | 01/21/2010 |
| human FucT-IV and -VII both contribute and cooperate in regulating L-selectin-, P-selectin-, and E-selectin-dependent rolling on PSGL-1, with FucT-VII playing a predominant role in conferring selectin binding activity to PSGL-1 | Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.
Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O. | 01/21/2010 |
| The Fuc-T VII promoter is transactivated by Tax in concert with CBP through a CRE-like sequence in a manner similar to that of viral CRE in HTLV-1 LTR. | Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element.
Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Suzuki T, Yoshida M, Kannagi R. | 01/21/2010 |
| H-Ras mediates FucT-VII induction in Jurkat T cells via the activation of the Raf, PI3K, and a distinct, H-Ras-specific effector signaling pathway. | H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells.
Zisoulis DG, Kansas GS. | 01/21/2010 |
| These results suggest that the FucT-VII may be a major regulator of the biosynthesis of the sLe(x)-epitopes on T lymphoblasts. | Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII.
Miyashiro M, Furuya S, Fujishige K, Sugita T. | 01/21/2010 |