| USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation. | USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation.
Zhao B, Xia Z, Yang B, Guo Y, Zhou R, Gu M, Liu M, Li Q, Bai W, Huang J, Zhang X, Zhu C, Leung KT, Chen C, Dong J. | 09/24/2024 |
| USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis. | USP7 Promotes TGF-β1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis.
Tang F, Gong H, Ke T, Yang W, Yang Y, Liu Z. | 08/28/2024 |
| USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1beta. | USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β.
Yan M, Su L, Wu K, Mei Y, Liu Z, Chen Y, Zeng W, Xiao Y, Zhang J, Cai G, Bai Y. | 07/10/2024 |
| USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice. | USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.
Yan M, Mei Y, Zhang T, Liu Z, Su L, Xiao Y, Zhong X, Lu Y. | 06/7/2024 |
| DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1alpha. | DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α.
Gao A, Zhang M, Zhu SQ, Zou S, Chen H, Li X, He C, Zhou L, Mei Y, Ding W, Zhou J, Zhou Y, Cao Y., Free PMC Article | 02/26/2024 |
| Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/beta-catenin pathway. | Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/β-catenin pathway.
Wang X, Zou C, Hou C, Bian Z, Jiang W, Li M, Zhu L. | 11/8/2023 |
| USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. | USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
Liu C, Sun L, Tan Y, Wang Q, Luo T, Li C, Yao N, Xie Y, Yi X, Zhu Y, Guo T, Ji J., Free PMC Article | 06/7/2023 |
| USP7 reduction leads to developmental failure of mouse early embryos. | USP7 reduction leads to developmental failure of mouse early embryos.
Zhang X, Xie XF, Li A, Song W, Li C, Li F, Li XZ, Fan XY, Zhou CY, Wang G, Sun QY, Ou XH. | 05/9/2023 |
| USP7 controls NGN3 stability and pancreatic endocrine lineage development. | USP7 controls NGN3 stability and pancreatic endocrine lineage development.
Manea T, Nelson JK, Garrone CM, Hansson K, Evans I, Behrens A, Sancho R., Free PMC Article | 05/3/2023 |
| Organ defects of the Usp7[K444R] mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation. | Organ defects of the Usp7(K444R) mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
Wu HT, Lin YT, Chew SH, Wu KJ., Free PMC Article | 04/4/2023 |
| USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development. | USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
Novellasdemunt L, Kucharska A, Baulies A, Hutton C, Vlachogiannis G, Repana D, Rowan A, Suárez-Bonnet A, Ciccarelli F, Valeri N, Li VSW., Free PMC Article | 02/23/2023 |
| USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses. | USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses.
Zhang N, Wang F, Zhang G, Zhang Q, Liu Y, Wang Q, Elsharkawy MS, Zheng M, Wen J, Zhao G, Li Q., Free PMC Article | 09/3/2022 |
| USP7 Attenuates Endoplasmic Reticulum Stress and NF-kappaB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation. | USP7 Attenuates Endoplasmic Reticulum Stress and NF-κB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation.
Dong X, Yang C, Luo Y, Dong W, Xu X, Wu Y, Wang J., Free PMC Article | 04/30/2022 |
| The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization. | The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization.
Zhang F, Zhang B, Tang R, Jiang H, Ji Z, Chen Y, Feng H. | 02/5/2022 |
| The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy. | The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy.
Lu X, Zhang Y, Zheng Y, Chen B., Free PMC Article | 09/25/2021 |
| Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance. | Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance.
Chen H, Zhu X, Sun R, Ma P, Zhang E, Wang Z, Fan Y, Zhou G, Mao R. | 09/11/2021 |
| USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors. | USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors.
de la Vega E, González N, Cabezas F, Montecino F, Blanco N, Olguín H. | 05/29/2021 |
| Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. | Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
He Y, Li W, Lv D, Zhang X, Zhang X, Ortiz YT, Budamagunta V, Campisi J, Zheng G, Zhou D., Free PMC Article | 05/15/2021 |
| USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. | USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638.
Ni W, Lin S, Bian S, Zheng W, Qu L, Fan Y, Lu C, Xiao M, Zhou P., Free PMC Article | 05/15/2021 |
| The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-kB subunits. | The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits.
Mitxitorena I, Somma D, Mitchell JP, Lepistö M, Tyrchan C, Smith EL, Kiely PA, Walden H, Keeshan K, Carmody RJ., Free PMC Article | 01/23/2021 |
| USP7 and TRIM32 were found to exhibit a dynamic and partially overlapping expression pattern during neuronal differentiation both in vitro and in vivo. Most importantly, we are able to demonstrate that USP7 deubiquitinates and thereby stabilizes c-Myc and that this function is required to maintain neural stem cell fate. | A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.
Nicklas S, Hillje AL, Okawa S, Rudolph IM, Collmann FM, van Wuellen T, Del Sol A, Schwamborn JC., Free PMC Article | 06/6/2020 |
| Evidence shows that USP7 localizes to replication foci independently of DNMT1 and indicates that USP7 does not control cell cycle-dependent levels of DNMT1. | Independent functions of DNMT1 and USP7 at replication foci.
Yarychkivska O, Tavana O, Gu W, Bestor TH., Free PMC Article | 10/20/2018 |
| Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin stimulation. | Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.
Forand A, Koumakis E, Rousseau A, Sassier Y, Journe C, Merlin JF, Leroy C, Boitez V, Codogno P, Friedlander G, Cohen I. | 11/25/2017 |
| EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape. | EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
Liefke R, Karwacki-Neisius V, Shi Y., Free PMC Article | 09/2/2017 |
| USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells. | USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.
Agathanggelou A, Smith E, Davies NJ, Kwok M, Zlatanou A, Oldreive CE, Mao J, Da Costa D, Yadollahi S, Perry T, Kearns P, Skowronska A, Yates E, Parry H, Hillmen P, Reverdy C, Delansorne R, Paneesha S, Pratt G, Moss P, Taylor AMR, Stewart GS, Stankovic T. | 08/19/2017 |