| TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1. | TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1.
Baek S, Chang JW, Yoo SM, Choo J, Jung S, Nah J, Jung YK., Free PMC Article | 07/31/2024 |
| TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression. | TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression.
Wang Z, Zhao P, Tian K, Qiao Z, Dong H, Li J, Guan Z, Su H, Song Y, Ma X., Free PMC Article | 04/29/2024 |
| Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. | Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis.
Zhang S, Lee SH, Nie L, Huang Y, Zou G, Jung YS, Jun S, Zhang J, Lien EM, Chen J, Park JI., Free PMC Article | 01/28/2023 |
| Tumor-Promoting Properties of TMEM9A in Breast Cancer Progression via Activating the Wnt/beta-Catenin Signaling Pathway. | Tumor-Promoting Properties of TMEM9A in Breast Cancer Progression via Activating the Wnt/β-Catenin Signaling Pathway.
He J, Bu Y, Li X, Zhang X, Ma L. | 01/14/2023 |
| TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. | TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI, Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI., Free PMC Articles: PMC7647947, PMC7647947 | 08/14/2021 |
| TMEM9-activated v-ATPase downregulates APC via lysosomal degradation, which hyperactivates WNT/beta-Catenin signaling. | TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI, Jung YS, Stratton SA, Lee SH, Kim MJ, Jun S, Zhang J, Zheng B, Cervantes CL, Cha JH, Barton MC, Park JI., Free PMC Articles: PMC7647947, PMC7647947 | 04/30/2021 |
| Data show that TMEM9 binds to and facilitates assembly of vacuolar-ATPase (v-ATPase), a vacuolar proton pump, resulting in enhanced vesicular acidification and trafficking. | TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.
Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, McCrea PD, Kopetz S, Park JI., Free PMC Article | 04/20/2019 |
| TMEM9 plays a significant role in TNF-alpha-enhanced cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the canonical Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. | TMEM9 mediates IL-6 and IL-1β secretion and is modulated by the Wnt pathway.
Wei W, Jiang F, Liu XC, Su Q. | 12/22/2018 |
| TMEM9 knockdown by RNA interference resulted in G1 arrest. | Effects of TMEM9 gene on cell progression in hepatocellular carcinoma by RNA interference.
Zhang Y, Ran Y, Xiong Y, Zhong ZB, Wang ZH, Fan XL, Ye QF. | 03/11/2017 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways | The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways.
Dodeller F, Gottar M, Huesken D, Iourgenko V, Cenni B. | 01/21/2010 |
| phylogenetically conserved, widely expressed transmembrane protein with a potential, but unknown function in intracellular transport that localizes to lysosomes and late endosomes | Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes.
Kveine M, Tenstad E, Døsen G, Funderud S, Rian E. | 01/21/2010 |