| RXRalpha Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc. | RXRα Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc.
Yu P, Yang K, Jiang M., Free PMC Article | 09/11/2021 |
| RXRalpha and MRTF-A have a synergistic effect in the retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells. | RXRα and MRTF-A have a synergistic effect in the retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells.
Luo Y, Liang C, Liu Y, Liu X, Xu Y. | 01/16/2021 |
| A complex and coordinated time-dependent interplay between pro- and anti-inflammatory signaling pathways highlights a potential anti-inflammatory role of LXR/RXR, PPARalpha/RXRalpha and STAT3 signaling pathways in resolving inflammatory corneal angiogenesis. | Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization.
Mukwaya A, Lennikov A, Xeroudaki M, Mirabelli P, Lachota M, Jensen L, Peebo B, Lagali N., Free PMC Article | 10/26/2019 |
| Data suggest cells of the adrenal gland that contain RXRalpha are primarily localized in zona fasciculata and adrenal medulla with RXRalpha almost exclusively localized in cell nucleus; cells that contain RXRbeta are primarily localized in zona fasciculata. RXR ligands, such as all-trans-retinoic acid and long-chain polyunsaturated fatty acids, are also present in the adrenal gland. | Fundamental studies of adrenal retinoid-X-receptor: Protein isoform, tissue expression, subcellular distribution, and ligand availability.
Cheng B, Al-Shammari FH, Ghader IA, Sequeira F, Thakkar J, Mathew TC. | 07/22/2017 |
| The results suggest that an increase in the expression of PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and importin-alpha3 expression/activity participates in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation during endotoxemia and thus have a beneficial effect in septic shock treatment | Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.
Senol SP, Temiz M, Guden DS, Cecen P, Sari AN, Sahan-Firat S, Falck JR, Dakarapu R, Malik KU, Tunctan B. | 12/31/2016 |
| The results imply that activation of RXRa was required for DHA protection whereas Trk receptors were not involved in this protection. | Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors.
German OL, Monaco S, Agnolazza DL, Rotstein NP, Politi LE., Free PMC Article | 03/1/2014 |
| RXRalpha were hardly detected in female brain, but were detected more frequently in male rats. | Expression of retinoic acid receptors and retinoid X receptors in normal and vitamin A deficient adult rat brain.
Arfaoui A, Lobo MV, Boulbaroud S, Ouichou A, Mesfioui A, Arenas MI. | 11/16/2013 |
| We showed that the embryo hearts from vitamin A insufficient groups exhibited ultrastructural changes and significantly lowe expression of GATA-4, RARalpha and gamma, and higher expression of RXRalpha and beta. | Ectopic expression of retinoic acid receptors and change of myocardial structure in the offspring heart with vitamin A deficiency.
Feng Y, Yu YM, Yin MZ, Hong L, Cai W. | 07/13/2013 |
| a potential role of CRBP1 in the regulation of beta-catenin turnover which can greatly affect the process of osteogenesis and adipogenesis of mesenchymal stem cells | Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXRα-induced β-catenin degradation.
Xu L, Song C, Ni M, Meng F, Xie H, Li G. | 06/16/2012 |
| The impaired RAR/RXR signaling and oxidative stress/JNK pathway forms a vicious circle, which significantly contributes to hyperglycemia induced cardiomyocyte apoptosis. | High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling.
Singh AB, Guleria RS, Nizamutdinova IT, Baker KM, Pan J., Free PMC Article | 04/21/2012 |
| Activation of RAR/RXR signaling protects cardiomyocytes from hyperglycemia, by reducing oxidative stress and inhibition of the renin angiotensin system. | Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system.
Guleria RS, Choudhary R, Tanaka T, Baker KM, Pan J., Free PMC Article | 04/16/2011 |
| Dex restored the expression of rBAT in septic rats by enhancing RXR[alpha], a process that might explain the mechanism underlying Dex's anticholestatic effect. | Retinoid X receptor alpha participation in dexamethasone-induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver.
Chen BC, Kuo KK, Chen KY, Liu CH, Tsai LY, Hsu HK, Hsu C. | 01/21/2010 |
| A chronic exposure to enriched uranium affects both mRNA and protein expressions of renal nuclear receptors involved in vitamin D metabolism, without any modification of the circulating vitamin D. | Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney.
Tissandié E, Guéguen Y, Lobaccaro JM, Grandcolas L, Aigueperse J, Gourmelon P, Souidi M. | 01/21/2010 |
| Decreased retinoid X receptor alpha expression is associated with hepatocellular carcinoma | Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats.
Ando N, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Tanaka T, Moriwaki H. | 01/21/2010 |
| mechanisms of RXR-alpha-mediated BAAT regulation during polymicrobial sepsis | Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis.
Chen YH, Hong IC, Kuo KK, Hsu HK, Hsu C. | 01/21/2010 |
| increase in RXR protein levels may be involved in the expression of T(3) specific actions in liver and pituitary. | Differential modulation of liver and pituitary triiodothyronine and 9-cis retinoid acid receptors by insulin-like growth factor I in rats.
Pellizas CG, del Mar Montesinos M, Masini-Repiso AM, Torres AI, Coleoni AH. | 01/21/2010 |
| Results support the involvement of RXR alpha in the growth of white adipose tissue after consumption of a high-fat diet. | Modification of RXRalpha expression according to the duration of a cafeteria diet.
Margareto J, Marti A, Martínez JA. | 01/21/2010 |
| Our studies reveal tissue dependent profiles of RXR agonists and support the idea of unsaturated fatty acids as physiological ligands of RXR | Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor.
Goldstein JT, Dobrzyn A, Clagett-Dame M, Pike JW, DeLuca HF. | 01/21/2010 |
| Alterations in peroxisomal metabolism observed in senescent liver may be a result of the decline in availability of RXR alpha receptor, and not the primary PPAR alpha receptor. | Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha.
Chao C, Youssef J, Rezaiekhaleigh M, Birnbaum LS, Badr M. | 01/21/2010 |
| Protein represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. | Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2.
Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP. | 01/21/2010 |
| PPARalpha was able to induce the activity of the rat SR-BI promoter in conjunction with RXRalpha | Activation of the rat scavenger receptor class B type I gene by PPARalpha.
Lopez D, McLean MP. | 01/21/2010 |