| Expression of p16(Ink4a) protein in pleomorphic adenoma and carcinoma ex pleomorphic adenoma proves diversity of tumour biology and predicts clinical course. | Expression of p16(Ink4a) protein in pleomorphic adenoma and carcinoma ex pleomorphic adenoma proves diversity of tumour biology and predicts clinical course.
Bartkowiak E, Piwowarczyk K, Bodnar M, Kosikowski P, Chou J, Woźniak A, Wierzbicka M., Free PMC Article | 08/27/2022 |
| Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy. | Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy.
Teramoto N, Ikeda M, Sugihara H, Shiga T, Matsuwaki T, Nishihara M, Uchida K, Yamanouchi K., Free PMC Article | 09/25/2021 |
| Angiotensin inhibition and cellular senescence in the developing rat kidney. | Angiotensin inhibition and cellular senescence in the developing rat kidney.
Yoo KH, Yim HE, Bae ES. | 02/6/2021 |
| the loss of Cdkn2a/2b, which are the most frequently lost foci in human MM, were observed in 8 cases of rat MM (homozygous deletion [5/8] and loss of heterozygosity [3/8]) by array-based comparative genomic hybridization techniques. | Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats.
Okazaki Y, Misawa N, Akatsuka S, Kohyama N, Sekido Y, Takahashi T, Toyokuni S., Free PMC Article | 04/25/2020 |
| streptozotocin-induced experimental diabetes mellitus induced p16 expression but did not show any difference in p53, Bcl-2, and Ki67 levels. | The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study.
Altun E, Yazici H, Arslan E, Tulaci KG, Erken HA., Free PMC Article | 04/4/2020 |
| 5-aza-CdR attenuated lung fibrosis in neonatal rats exposed to hyperoxia by lowering hydroxyproline and TGF-beta1 expression and via re-expression of P16 in neonatal rats | 5-aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hyperoxia-induced lung fibrosis via re-expression of P16 in neonatal rats.
Zhao SM, Wu HM, Cao ML, Han D. | 05/18/2019 |
| Our findings indicated that p16 alteration is a common event in the carcinogenesis of this model and that the mutation pattern is analogous to that of human lesions. | Mutations in the p16 gene in DMBA-induced pancreatic intraepithelial neoplasia and pancreatic cancer in rats.
Zhu Z, Liu T, Han F, Zhan SD, Wang CY. | 07/16/2016 |
| These findings indicate that p16(INK4a) plays a significant role in the inhibition of DNA synthesis. | Role of p16(INK4a) in the inhibition of DNA synthesis stimulated by HGF or EGF in primary cultured rat hepatocytes.
Harashima M, Seki T, Ariga T, Niimi S. | 06/14/2014 |
| Ezh2 knockdown induced changes in DNA methylation of the p16INK4a gene and premature senescence in mesenchymal stem cells. | H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells.
Zheng Y, He L, Wan Y, Song J. | 07/6/2013 |
| Data show that an accumulation of p16(INK4a)-positive senescent astrocytes may link increased age and increased risk for sporadic Alzheimer's disease (AD). | Astrocyte senescence as a component of Alzheimer's disease.
Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C., Free PMC Article | 03/9/2013 |
| hIGF-1 gene therapy improved the expression of rIGF-1 and PCNA protein in myocardium, and also suppressed the expression of p16(INK4a) protein post-infarction. | Change of p16(INK4a) and PCNA protein expression in myocardium after injection of hIGF-1 gene modified skeletal myoblasts into post-infarction rats.
Gao Y, Lu Y, Mi S, Liu X, Su G, Rong S. | 02/16/2013 |
| Maternal high fat exposure represses p16 (INK4a) gene expression in the mammary gland of offspring through changes of histone modifications and HDAC3 binding activity within the regulatory regions of the p16 (INK4a) gene. | Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet.
Zheng S, Li Q, Zhang Y, Balluff Z, Pan YX., Free PMC Article | 09/29/2012 |
| Subchronic grape juice concentrate administration was able to modulate cell cycle control by downregulation of p16 immunoexpression in high fat diet-induced liver steatosis in rats. | Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats.
Ferreira AO, Gollücke AP, Noguti J, da Silva VH, Yamamura ET, Ribeiro DA. | 06/9/2012 |
| In obesity prone rats, the increase of p16(INK4a) was associated with the higher acetylation levels of histone H4 at the p16(INK4a) promoter and coding region and lower methylation level of histone H3 lysine-27 in the p16(INK4a) coding region. | Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model.
Zhang X, Zhou D, Strakovsky R, Zhang Y, Pan YX., Free PMC Article | 04/21/2012 |
| Chromatin immunoprecipitation (ChIP) assay demonstrated that the altered p16 mRNA level and transcription rate in LP offspring resulted from histone code changes, including the reduced acetylation of histone H4 and the dimethylation of histone H3 | Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats.
Zheng S, Pan YX. | 10/22/2011 |
| These findings suggest that loss of function or decrease of RAR-beta2, RASSF1A, and CDKN2A, as well as the hypermethylation of 5' region of these genes, are related with nickel exposure. | Methylation of RAR-β2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats.
Zhang J, Zhang J, Li M, Wu Y, Fan Y, Zhou Y, Tan L, Shao Z, Shi H. | 09/17/2011 |
| Chromosome aberrations of this protein in radiation-induced and spontaneous rat mammary carcinomas. | DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas.
Iizuka D, Imaoka T, Takabatake T, Nishimura M, Kakinuma S, Nishimura Y, Shimada Y. | 10/30/2010 |
| iron-induced peritoneal mesothelioma associated with CDKN2A/2B homozygous deletion, supporting the hypothesis that oxidative stress by iron overload is a major cause of CDKN2A/2B homozygous deletion | Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.
Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, Toyokuni S. | 03/29/2010 |
| betaine affects p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model | Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model.
Du YP, Peng JS, Sun A, Tang ZH, Ling WH, Zhu HL., Free PMC Article | 01/21/2010 |
| Results suggest that p16CDKN2A mutations in exon 2 are not involved in the multistep tongue carcinogenesis nduced by 4NQO. | No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Minicucci EM, da Silva GN, Ribeiro DA, Favero Salvadori DM. | 01/21/2010 |
| Ink4a/Cdk4/Rb1 pathway deregulation, more than Arf/Mdm2/Tp53 pathway, has a major role in the development of these tumors through p16(Ink4a) deregulation. | Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.
Bastide K, Guilly MN, Bernaudin JF, Joubert C, Lectard B, Levalois C, Malfoy B, Chevillard S. | 01/21/2010 |
| PPARalpha trans-repression involved the recruitment of the retinoblastoma (RB) family proteins p107 and p130 to the TERT promoter resulting in impaired E2F-1 binding, an effect that was dependent on p16. | The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D., Free PMC Article | 01/21/2010 |
| Hypertension induces cellular senescence via p16(INK4a), possibly through p38, thereby contributing to hypertensive target organ damage. | Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A. | 01/21/2010 |
| The 2-methoxyestradiol-induced apoptosis of rat osteosarcoma and rat malignant fibrous histiocytoma cells was accompanied by caspase-3 activation through p16 induction. | Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines.
Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y. | 01/21/2010 |
| the expression of cell cycle regulator p16 is not affected by diabetes in the studied rat model of oral oncogenesis | Expression of cell cycle regulator p16 is not affected by diabetes during oral oncogenesis.
Vairaktaris E, Goutzanis L, Nkenke E, Spyridonidou S, Vassiliou S, Derka S, Vylliotis A, Yapijakis C, Lazaris A, Patsouris E. | 01/21/2010 |