| Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation? | Adverse outcome pathway exploration of furan-induced liver fibrosis in rats: Genotoxicity pathway or oxidative stress pathway through CYP2E1 activation?
Tang X, Miao Y, Cao L, Liu Y, Zhu X, Zhang J, Wang D, Li X, Zhang L, Huo J, Chen J. | 11/18/2023 |
| CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma. | CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.
Ishteyaque S, Yadav KS, Verma S, Washimkar KR, Mugale MN. | 08/30/2023 |
| Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling. | Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling.
Wang J, Yang H, Wang C, Kan C. | 07/31/2023 |
| Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure. | Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure.
Zhang Y, Zhang L, Xu P, Qin X, Wang P, Cheng Y, Yao B, Wang X. | 07/23/2022 |
| Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion. | Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.
Shi JH, Yang DJ, Jin Q, Cheng N, Shi YB, Bai Y, Yu DS, Guo WZ, Ge GB, Zhang SJ., Free PMC Article | 05/14/2022 |
| Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration. | Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration.
Chen YH, Chiu WC, Xiao Q, Chen YL, Shirakawa H, Yang SC., Free PMC Article | 12/18/2021 |
| Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart. | Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: Role of reduced PER2 expression and CYP2E1 hyperactivity in the heart.
Katary M, Abdel-Rahman AA., Free PMC Article | 09/18/2021 |
| Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes. | Validation of an HPLC Method for the Simultaneous Quantification of Metabolic Reaction Products Catalysed by CYP2E1 Enzyme Activity: Inhibitory Effect of Cytochrome P450 Enzyme CYP2E1 by Salicylic Acid in Rat Liver Microsomes.
Salhab H, Naughton DP, Barker J., Free PMC Article | 11/21/2020 |
| The differential changes in CYP2E1 in the processes of alcohol-induced and immune-mediated liver injury may result from the differential expression of inflammatory cytokines and iNOS after NF-kappaB activation, leading to the NF-kappaB-mediated transcriptional regulation of rat CYP2E1 by two independent signaling pathways. | NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways.
Lin Q, Kang X, Li X, Wang T, Liu F, Jia J, Jin Z, Xue Y., Free PMC Article | 04/11/2020 |
| Overall, high CYP2E1 activity aggravates hepatofibrosis by restraining M2 macrophage polarization, providing a novel insight for understanding the profibrotic activity of CYP2E1 and a promising avenue for hepatofibrosis therapy. | High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype.
Guo YY, Xu C, Fang Y, Wang CE, Gao N, Wen Q, Qiao HL. | 11/9/2019 |
| acute Formaldehyde (FA) poisoning suppressed the activities of CYP2C11, CYP2E1, and CYP3A2 and induced the activity of CYP1A2 in rats. And the change of CYP450 activity caused by acute FA poisoning may be associated with FA potential carcinogenic effects on the airways. | The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.
Xu M, Tang H, Rong Q, Zhang Y, Li Y, Zhao L, Ye G, Shi F, Lv C., Free PMC Article | 03/3/2018 |
| Data suggest that combined treatment with non-nutritive sweetener aspartame and insulin in a rat model of juvenile diabetes induces CYP2E1 in neurons of cerebrum and cerebellum without modifying CYP2E1 in liver, while CYP3A2 is induced in cerebrum/cerebellum and in liver. | Aspartame Administration and Insulin Treatment Altered Brain Levels of CYP2E1 and CYP3A2 in Streptozotocin-Induced Diabetic Rats.
Nosti-Palacios R, Gómez-Garduño J, Molina-Ortiz D, Calzada-León R, Dorado-González VM, Vences-Mejía A. | 01/27/2018 |
| Impaired growth hormone-mediated signaling is observed in ethanol-exposed hepatocytes and is explained by differential effects of alcohol dehydrogenase (ADH)- and cytochrome P450 2E1 (CYP2E1)-mediated ethanol metabolism on the Jak2/STAT5B pathway. | Ethanol metabolism by alcohol dehydrogenase or cytochrome P(450) 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling.
Doody EE, Groebner JL, Walker JR, Frizol BM, Tuma DJ, Fernandez DJ, Tuma PL., Free PMC Article | 12/16/2017 |
| The results suggest that changes in coumarin pharmacokinetics and CYP2E1 subcellular distribution contribute to resistance to coumarin-induced hepatic necrosis, while cytotoxicity of metabolic conjugates shown in vitro may contribute to bile duct damage upon repeated coumarin administration. | Changes in coumarin kinetics and subcellular localization of CYP2E1 contribute to bile duct damage and reduce hepatocellular damage after repeated administration of coumarin in rats.
Tanaka Y, Fujii W, Hori H, Kitagawa Y, Ozaki K. | 10/21/2017 |
| The isoniazid-LPS-induced inflammation model might prove valuable in revealing the hepatotoxic mechanisms of isoniazid and the crucial role played by CYP2E1 in the initiation and propagation of isoniazid-induced liver damage. | Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment.
Hassan HM, Guo H, Yousef BA, Guerram M, Hamdi AM, Zhang L, Jiang Z., Free PMC Article | 09/16/2017 |
| The CYP2E1-PPARalpha axis may play a role in ethanol-induced neurotoxicity via the alteration of the genes related with synaptic function | The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARα down-regulation.
Na S, Li J, Zhang H, Li Y, Yang Z, Zhong Y, Dong G, Yang J, Yue J. | 06/24/2017 |
| The results suggested that kaempferol exhibited a weak inhibition of CYP2E1 activity with an IC50 of 60.26 +/- 2.54 muM, while quercetin and kaempferol caused a moderate inhibition of CYP3A4 activity with IC50 values of 18.77 +/- 1.69 muM and 32.65 +/- 1.32 muM, respectively. Isoquercitrin and astragalin had no effects on the activities of either CYP2E1 or CYP3A4. | Effects of Flavonoids in Lysimachia clethroides Duby on the Activities of Cytochrome P450 CYP2E1 and CYP3A4 in Rat Liver Microsomes.
Zhang ZJ, Xia ZY, Wang JM, Song XT, Wei JF, Kang WY., Free PMC Article | 04/15/2017 |
| Subcellular localization of CYP2E1 results in distinctly different enzyme activities that could impact overall metabolic clearance and/or activation of substrates and thus impact the interpretation and prediction of toxicological outcomes. | Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.
Hartman JH, Martin HC, Caro AA, Pearce AR, Miller GP., Free PMC Article | 03/12/2016 |
| Modulation of testicular cytochrome P450 2E1 mRNA and protein expression could change the functioning of this isozyme in target organs and take part in the mechanism of ethanol gonadotoxicity. | CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen.
Shayakhmetova GM, Bondarenko LB, Kovalenko VM, Ruschak VV. | 09/12/2015 |
| This study showed significant changes in the activity and protein and mRNA expression of CYP2E1 or CYP3A1 in rats after exposure to chronic high altitude hypoxia. | The activity, protein, and mRNA expression of CYP2E1 and CYP3A1 in rats after exposure to acute and chronic high altitude hypoxia.
Li X, Wang X, Li Y, Zhu J, Su X, Yao X, Fan X, Duan Y. | 09/12/2015 |
| Data suggest that Cyp2e1 is induced in testes during infertility as the result of either experimental type I diabetes or experimental alcoholism; level of Cyp2e1 mRNA in testes correlates with defect in spermatogenesis. | Correlation between spermatogenesis disorders and rat testes CYP2E1 mRNA contents under experimental alcoholism or type I diabetes.
Shayakhmetova GM, Bondarenko LB, Matvienko AV, Kovalenko VM. | 08/22/2015 |
| Schizonepetin induced the expression of CYP3A1, CYP1A2 and CYP2E1 at dosages of 24 and 48 mg/kg. | Effects of schizonepetin on activity and mRNA expression of cytochrome p450 enzymes in rats.
Bao B, Geng T, Cao Y, Yao W, Zhang L, Ding A., Free PMC Article | 07/4/2015 |
| In testes of isoniazid-treated rats CYP2E1 may act as a trigger in generating of reactive oxygen species and other toxic metabolites which subsequently mediates DNA damage, spermatogenesis disturbances, and altered male fertilizing capacity. | Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders.
Shayakhmetova GM, Bondarenko LB, Voronina AK, Anisimova SI, Matvienko AV, Kovalenko VM. | 05/16/2015 |
| During CYP2E1-induced oxidative stress, transcription factor Nrf2 has a role in the early adaptive response. Inhibition of CYP2E1 coupled with the prior induction of Nrf2 may be a tool to reduce CYP2E1-mediated rhabdomyolysis-induced acute kidney injury. | Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury.
Wang Z, Shah SV, Liu H, Baliga R. | 05/16/2015 |
| The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs. | CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
Ahmad I, Shukla S, Singh D, Chauhan AK, Kumar V, Singh BK, Patel DK, Pandey HP, Singh C. | 02/14/2015 |