| FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB. | FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB.
Kong X, Feng L, Yan D, Li B, Yang Y, Ma X., Free PMC Article | 03/18/2024 |
| Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation. | Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Sourris KC, Ding Y, Maxwell SS, Al-Sharea A, Kantharidis P, Mohan M, Rosado CJ, Penfold SA, Haase C, Xu Y, Forbes JM, Crawford S, Ramm G, Harcourt BE, Jandeleit-Dahm K, Advani A, Murphy AJ, Timmermann DB, Karihaloo A, Knudsen LB, El-Osta A, Drucker DJ, Cooper ME, Coughlan MT. | 01/8/2024 |
| Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells. | Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells.
Chang JT, Liang YJ, Leu JG. | 01/21/2023 |
| Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats. | Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats.
Barron M, Hayes H, Fernando DG, Geurts AM, Kindel TL., Free PMC Article | 09/17/2022 |
| Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats. | Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.
Liu X, Patel KP, Zheng H., Free PMC Article | 03/5/2022 |
| Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses. | Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses.
Ma L, Ju P, Wang W, Wei J, Wang W, Zhao M, Ahmad KA, Wang Y, Chen J., Free PMC Article | 02/5/2022 |
| Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis. | Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
Zheng Y, Xiao Y, Zhang D, Zhang S, Ouyang J, Li L, Shi W, Zhang R, Liu H, Jin Q, Chen Z, Xu D, Wu L., Free PMC Article | 01/22/2022 |
| Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain. | Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain.
Farkas E, Szilvásy-Szabó A, Ruska Y, Sinkó R, Rasch MG, Egebjerg T, Pyke C, Gereben B, Knudsen LB, Fekete C., Free PMC Article | 10/9/2021 |
| The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R. | The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R.
López-Ferreras L, Eerola K, Shevchouk OT, Richard JE, Nilsson FH, Jansson LE, Hayes MR, Skibicka KP. | 07/24/2021 |
| GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats. | GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.
Fortin SM, Lipsky RK, Lhamo R, Chen J, Kim E, Borner T, Schmidt HD, Hayes MR., Free PMC Article | 07/17/2021 |
| Glucagon-like peptide-1 receptor undergoes importin-alpha-dependent nuclear localization in rat aortic smooth muscle cells. | Glucagon-like peptide-1 receptor undergoes importin-α-dependent nuclear localization in rat aortic smooth muscle cells.
Zhang X, Fan S, Zhang L, Shi Y. | 05/8/2021 |
| Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro. | Exendin-4 Promotes Schwann Cell Survival/Migration and Myelination In Vitro.
Takaku S, Tsukamoto M, Niimi N, Yako H, Sango K., Free PMC Article | 05/1/2021 |
| Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats. | Activation of GLP-1 receptors attenuates oxycodone taking and seeking without compromising the antinociceptive effects of oxycodone in rats.
Zhang Y, Kahng MW, Elkind JA, Weir VR, Hernandez NS, Stein LM, Schmidt HD., Free PMC Article | 01/2/2021 |
| Liraglutide reduces hyperglycemia-induced cardiomyocyte death through activating glucagon-like peptide 1 receptor and targeting AMPK pathway. | Liraglutide reduces hyperglycemia-induced cardiomyocyte death through activating glucagon-like peptide 1 receptor and targeting AMPK pathway.
Ma G, Liu Y, Wang Y, Wen Z, Li X, Zhai H, Miao L, Luo J. | 12/12/2020 |
| Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats. | Central Glucagon-like Peptide-1 Receptor Signaling via Brainstem Catecholamine Neurons Counteracts Hypertension in Spontaneously Hypertensive Rats.
Katsurada K, Nakata M, Saito T, Zhang B, Maejima Y, Nandi SS, Sharma NM, Patel KP, Kario K, Yada T., Free PMC Article | 10/24/2020 |
| Glucagon-Like Peptide-1 Receptor expression in renal tubules is increased in early sepsis, which may explain the protective effect of endogenous glucagon-like peptide-1 against sepsis-related inflammation. | Renal Tubular Glucagon-Like Peptide-1 Receptor Expression Is Increased in Early Sepsis but Reduced in Chronic Kidney Disease and Sepsis-Induced Kidney Injury.
Choi JH, Kim SJ, Kwon SK, Kim HY, Jeon H., Free PMC Article | 05/2/2020 |
| this study also aims to determine the active ingredients of H. sabdariffa (Hib) that interact with sodium-glucose cotransporter-1 (SGLT-1) so that it can increase GLP-1 secretion in the ileum and interact with GLP-1 receptors (GLP-1R) in the pancreas. | The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like Peptide-1 via SGLT-1 and GLPR in DM Rats.
Kartinah NT, Fadilah F, Ibrahim EI, Suryati Y., Free PMC Article | 04/25/2020 |
| GLP-1 receptors are expressed in neurons known to release insulin in the cerebral cortex in rats | Expression of GLP-1 receptors in insulin-containing interneurons of rat cerebral cortex.
Csajbók ÉA, Kocsis ÁK, Faragó N, Furdan S, Kovács B, Lovas S, Molnár G, Likó I, Zvara Á, Puskás LG, Patócs A, Tamás G. | 02/22/2020 |
| GLP-1R was decreased in patients with temporal lobe epilepsy and in pentylenetetrazole -induced epilepsy rats and the administration of liraglutide decreased seizure severity, which indicates that liraglutide exerts antiepileptic effects. | Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.
Wen Y, Wu K, Xie Y, Dan W, Zhan Y, Shi Q. | 12/14/2019 |
| findings suggested that ghrelin treatment may alter the mRNA expression levels of CB1 and GLP-1R in the liver of rats with type 2 diabetes mellitus | Changes in the expression levels of CB1 and GLP-1R mRNAs and microRNAs 33a and 122 in the liver of type 2 diabetic rats treated with ghrelin.
Coskun ZM, Beydogan AB, Bolkent S. | 12/14/2019 |
| results indicate that GLP-1R is a therapeutic target for the treatment of osteoarthritis, and that liraglutide could be a therapeutic candidate for this clinical application. | Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat.
Chen J, Xie JJ, Shi KS, Gu YT, Wu CC, Xuan J, Ren Y, Chen L, Wu YS, Zhang XL, Xiao J, Wang DZ, Wang XY., Free PMC Article | 09/21/2019 |
| Significant decreases in the levels of GLP-1 and GLP-1R were observed in the hippocampi of rats with yyperthermia-induced seizures. GLP-1R pharmacological inhibitor exendin9-39 increased hyperthermia- induced seizure severity in rats and promoted neuronal firing activity in cultured neurons. Results suggest that inhibition of GLP-1R signaling promotes seizure activity. | The role of the GLP-1/GLP-1R signaling pathway in regulating seizure susceptibility in rats.
Zhang Y, Fang J, Feng W, Sun Q, Xu J, Xia Q. | 07/27/2019 |
| Results suggest that dorsal lateral septum-projecting GLP-1 neurons play a role in both inhibiting intake during normal, non-stressed feeding conditions as well as in the response to acute restraint stress, but do not appear to influence the neuroendocrine stress response. Findings suggest that the roles of GLP-1 neurons and brain GLP-1R populations in behavioral and physiological responses to stress are heterogeneous. | Endogenous GLP-1 in lateral septum contributes to stress-induced hypophagia.
Terrill SJ, Maske CB, Williams DL., Free PMC Article | 04/27/2019 |
| GLP-1R regulates cell growth, at least partially, through regulating cAMP/PKA/IDE signaling pathway in ABETA(1-42)-treated PC12 cells. | GLP-1 receptor regulates cell growth through regulating IDE expression level in Aβ1-42-treated PC12 cells.
Li H, Cao L, Ren Y, Jiang Y, Xie W, Li D., Free PMC Article | 04/20/2019 |
| Glp1r knockdown in hypothalamus reduced thermogenesis, increased body weight gain, adiposity and induced hepatic steatosis. | Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity.
Lee SJ, Sanchez-Watts G, Krieger JP, Pignalosa A, Norell PN, Cortella A, Pettersen KG, Vrdoljak D, Hayes MR, Kanoski SE, Langhans W, Watts AG., Free PMC Article | 04/13/2019 |