| Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation. | Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Xu L, Yang M, Wei A, Wei Z, Qin Y, Wang K, Li B, Chen K, Liu C, Li C, Wang T., Free PMC Article | 06/26/2024 |
| Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats. | Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats.
Wu X, Wang Z, Li H, Xie X, Wu J, Shen H, Li X, Wang Z, Chen G. | 01/15/2022 |
| The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles. | The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles.
Ahmadi A, Sheikholeslami-Vatani D, Ghaeeni S, Baazm M. | 05/22/2021 |
| Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions. | Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions.
Elizondo-Vega R, Oyarce K, Salgado M, Barahona MJ, Recabal A, Ordenes P, López S, Pincheira R, Luz-Crawford P, García-Robles MA., Free PMC Article | 11/28/2020 |
| 7ACC2 is an inhibitor of mitochondrial pyruvate transport; the blockade of pyruvate import into mitochondria prevents extracellular lactate uptake as efficiently as a MCT1 inhibitor | Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.
Corbet C, Bastien E, Draoui N, Doix B, Mignion L, Jordan BF, Marchand A, Vanherck JC, Chaltin P, Schakman O, Becker HM, Riant O, Feron O., Free PMC Article | 12/29/2018 |
| Following cerebral ischemia, monocarboxylate transporter 1 (MCT1) expression was upregulated in the peri-infarct striatum but not in the cortex of the brain. In vitro ischemia models were used to induce oligodendrocyte stress as well. An increase in MCT1 expression was detected in oligodendrocyte precursor cells after a mild oxygen-glucose deprivation. | Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses.
Zhou P, Guan T, Jiang Z, Namaka M, Huang QJ, Kong JM., Free PMC Article | 12/22/2018 |
| The MCT1 mRNA and membrane protein expression varied with estrous cycle stage, with OVX females having higher expression than males, indicating that female sex hormones may play a role in MCT1 regulation. | Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking.
Cao J, Ng M, Felmlee MA. | 07/21/2018 |
| Our results are proposing that in the developing brain white matter, MCT1 is predominately expressed in oligodendrocyte though it mainly expressed in astrocyte in early postnatal, which indicate that MCT1 may involve in the oligodendrocyte development and myelination. | Postnatal alteration of monocarboxylate transporter 1 expression in the rat corpus callosum.
Dong F, Liu Y, Zhang Z, Guo R, Ma L, Qu X, Yu H, Fan H, Yao R. | 03/3/2018 |
| Decreased expression of MCT1/4 in distal airway epithelium may disrupt lung branching morphogenesis and thus contribute to the development of pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model. | Decreased expression of monocarboxylate transporter 1 and 4 in the branching airway epithelium of nitrofen-induced congenital diaphragmatic hernia.
Takahashi T, Friedmacher F, Zimmer J, Puri P. | 04/29/2017 |
| The transport mechanism of 4-PBA from blood to brain across the BBB likely involves MCT1. | In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1).
Lee NY, Kang YS. | 03/25/2017 |
| The Canonical Wnt/beta-Catenin Pathway Increased Expression of MCT1 on the Plasma Membrane of Rat Brain Endothelial Cells. | Regulation of Monocarboxylic Acid Transporter 1 Trafficking by the Canonical Wnt/β-Catenin Pathway in Rat Brain Endothelial Cells Requires Cross-talk with Notch Signaling.
Liu Z, Sneve M, Haroldson TA, Smith JP, Drewes LR., Free PMC Article | 09/3/2016 |
| MPC inhibition is the most sensitive anti-tumour target for LND, with additional inhibitory effects on MCT-mediated L-lactic acid efflux and glutamine/glutamate oxidation. | The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP., Free PMC Article | 08/13/2016 |
| results suggest that the EA treatments activated lactate metabolism in the resident astrocytes around the ischemic area and up-regulated the expression of MCT1 in these astrocytes which facilitated the transfer of intracellular lactate | Electro-acupuncture up-regulates astrocytic MCT1 expression to improve neurological deficit in middle cerebral artery occlusion rats.
Lu Y, Zhao H, Wang Y, Han B, Wang T, Zhao H, Cui K, Wang S. | 09/26/2015 |
| The metabolic Km for L-lactate closely resembled that for MCT-mediated hepatic uptake in vitro | Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between γ-hydroxybutyrate and L-lactate.
Morse BL, Vijay N, Morris ME., Free PMC Article | 02/7/2015 |
| After a 2-h exercise session, MCT1 increased in the cortex and hippocampus 5h postexercise. | Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.
Takimoto M, Hamada T. | 01/31/2015 |
| Cyclic AMP signaling reduces the functionality of Mct1 in cerebrovascular endothelial cells. | Regulation of monocarboxylic acid transporter-1 by cAMP dependent vesicular trafficking in brain microvascular endothelial cells.
Uhernik AL, Li L, LaVoy N, Velasquez MJ, Smith JP., Free PMC Article | 09/20/2014 |
| Results suggest that acute exercise-induced increases in MCT1 and MCT4 mRNA expression may be possibly mediated by AMPK activation, at least in part in fast-twitch muscle. | Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle.
Takimoto M, Takeyama M, Hamada T. | 01/11/2014 |
| These data indicate that MCT1 is the high affinity lactate transporter and MCT4 is the high affinity butyrate transporter in the intestinal epithelial cell line IEC-18. | Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line.
Kekuda R, Manoharan P, Baseler W, Sundaram U. | 06/8/2013 |
| we show for the first time the regulated and unregulated vesicular trafficking of Mct1 in cerebrovascular endothelial cells; processes which have significance for better understanding normal brain energy metabolism | Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells.
Smith JP, Uhernik AL, Li L, Liu Z, Drewes LR., Free PMC Article | 03/16/2013 |
| MCT1 was lost on microvessels and upregulated on astrocytes in the hippocampal formation in all models of temporal lobe epilepsy. | Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.
Lauritzen F, Perez EL, Melillo ER, Roh JM, Zaveri HP, Lee TS, Wang Y, Bergersen LH, Eid T., Free PMC Article | 07/28/2012 |
| MCT1 is increased at all ages, occurring 5-10-fold more in adult than in immature rats with status epilepticus. | Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat.
Leroy C, Pierre K, Simpson IA, Pellerin L, Vannucci SJ, Nehlig A., Free PMC Article | 05/26/2012 |
| Transfer of nicotinate from blood to retina across the inner blood-retinal barrier occurs primarily via H(+)-coupled monocarboxylate transporters. | Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier.
Tachikawa M, Murakami K, Martin PM, Hosoya K, Ganapathy V., Free PMC Article | 03/17/2012 |
| MCT1 expression was doubled (P </= 0.05) in rats on the ketogenic diet. | Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats.
Pifferi F, Tremblay S, Croteau E, Fortier M, Tremblay-Mercier J, Lecomte R, Cunnane SC. | 09/17/2011 |
| Administration of Phellinus linteus increased endurance exercise performance through inhibition of serotonin production in the brain and increased the expression of MCT1 and MCT4 in muscles. | Effects of Phellinus linteus administration on serotonin synthesis in the brain and expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats.
Seo JH, Sung YH, Kim KJ, Shin MS, Lee EK, Kim CJ. | 08/20/2011 |
| tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. | MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.
Cortés-Campos C, Elizondo R, Llanos P, Uranga RM, Nualart F, García MA., Free PMC Article | 08/6/2011 |