| Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats. | Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Hamamah S, Hajnal A, Covasa M., Free PMC Article | 06/15/2023 |
| Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade. | Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
Xiang T, Li JH, Su HY, Bai KH, Wang S, Traub RJ, Cao DY., Free PMC Article | 10/15/2022 |
| The critical role of CCK in the regulation of food intake and diet-induced obesity. | The critical role of CCK in the regulation of food intake and diet-induced obesity.
Cawthon CR, de La Serre CB. | 01/15/2022 |
| Satiety induced by bile acids is mediated via vagal afferent pathways. | Satiety induced by bile acids is mediated via vagal afferent pathways.
Wu X, Li JY, Lee A, Lu YX, Zhou SY, Owyang C., Free PMC Article | 05/22/2021 |
| This study demonistrated that Cckar and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. | Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.
Parks GS, Wang L, Wang Z, Civelli O., Free PMC Article | 05/23/2015 |
| Data suggest that Apo AIV (apolipoprotein AIV) in NTS (nucleus of the solitary tract) or/and peripheral Cck (cholecystokinin) require vagal Cck1r/Cckar signaling to elicit satiation; high-fat diet reduces satiating capacity of these signals. | Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.
Lo CC, Davidson WS, Hibbard SK, Georgievsky M, Lee A, Tso P, Woods SC., Free PMC Article | 06/21/2014 |
| factors secondary to obesity and/or diabetes rather than impaired CCK-1 receptor signaling may contribute to altered CART expression | Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats.
Armbruszt S, Abraham H, Figler M, Kozicz T, Hajnal A., Free PMC Article | 12/14/2013 |
| CCK-A receptors are located on the cell bodies of cholinergic interneurons in the corpus striatum. | Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
Petkova-Kirova P, Giovannini MG, Kalfin R, Rakovska A. | 08/31/2013 |
| Activation of duodenal PKC-delta leads to the stimulation of CCK release and activation of the CCK-A receptor signaling axis to lower glucose production in normal rats. | Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production.
Breen DM, Yue JT, Rasmussen BA, Kokorovic A, Cheung GW, Lam TK., Free PMC Article | 02/4/2012 |
| Data indicate that the Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK(1)-R affinity and 15-fold for the human CCK(1)-R relative to the reference compound 12 (VL-0395). | New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).
Pavan MV, Lassiani L, Berti F, Stefancich G, Ciogli A, Gasparrini F, Mennuni L, Ferrari F, Escrieut C, Marco E, Makovec F, Fourmy D, Varnavas A. | 12/10/2011 |
| Data suggest L-364,718 potentiates electroacupuncture analgesia through the CCK-A receptor of pain-excited and pain-inhibited neurons in the nucleus parafascicularis. | L-364,718 potentiates electroacupuncture analgesia through cck-a receptor of pain-related neurons in the nucleus parafascicularis.
Shi TF, Yang CX, Yang DX, Gao HR, Zhang GW, Zhang D, Jiao RS, Xu MY, Qiao HQ. | 04/23/2011 |
| CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production | CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
Berna MJ, Seiz O, Nast JF, Benten D, Bläker M, Koch J, Lohse AW, Pace A., Free PMC Article | 01/15/2011 |
| our results demonstrate for the first time, that CCK-1 receptor plays a crucial role in both meal-induced and fasting insulin sensitization | Involvement of cholecystokinin in baseline and post-prandial whole body insulin sensitivity in rats.
Peitl B, Döbrönte R, Drimba L, Sári R, Varga A, Németh J, Pázmány T, Szilvássy Z. | 12/11/2010 |
| Present study examined the contribution of genetics, sex and early maternal environment to anxiety-like behaviors and locomotion in CCK1 knockout rats, suggesting that the mutation may predispose (rather than induce) the animals to an anxious phenotype. | Anxiety-like behavior and locomotion in CCK1 knockout rats as a function of strain, sex and early maternal environment.
Schroeder M, Weller A. | 08/9/2010 |
| Pancreatic islet CCK1/2 receptors initiate somatosatin secretion through constitutive secretion controlled at the level of protein synthesis. | Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line.
El-Kouhen K, Morisset J. | 05/31/2010 |
| The results of this study showed that increased oil intake in cck-1 receptor deficient rats is driven by both peripheral deficits to satiation and altered orosensory sensitivity. | Altered orosensory sensitivity to oils in CCK-1 receptor deficient rats.
Swartz TD, Hajnal A, Covasa M., Free PMC Article | 03/8/2010 |
| Gastric leptin may exert acute sympathoinhibitory and cardiovascular effects via vagal transmission and CCK(1) receptor activation and may play a separate role to adipose leptin in short-term cardiovascular regulation. | Gastric leptin: a novel role in cardiovascular regulation.
Sartor DM, Verberne AJ. | 02/22/2010 |
| endogenous CCK-1 receptor signaling in infants is a potential pathway through which maternal-pup interactions regulate the development and functional organization of emotional circuits that control anxiety-like behavior in the offspring. | A potential gastrointestinal link between enhanced postnatal maternal care and reduced anxiety-like behavior in adolescent rats.
Weber BC, Manfredo HN, Rinaman L., Free PMC Article | 01/21/2010 |
| The findings suggest that in addition to previously described deficits in peripheral satiety signals and augmented orexigenic regulation, the anorectic effect of CART peptide may also be diminished in CCK-1 deficient rats. | Cocaine- and amphetamine-regulated transcript peptide immunoreactivity in the brain of the CCK-1 receptor deficient obese OLETF rat.
Abraham H, Covasa M, Hajnal A., Free PMC Article | 01/21/2010 |
| Fischer 344 rats lacking the cholecystokinin-1 receptor gene show normal feeding and body weight. | Normal feeding and body weight in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.
Blevins JE, Overduin J, Fuller JM, Cummings DE, Matsumoto K, Moralejo DH., Free PMC Article | 01/21/2010 |
| cholecystokinin CCK1 and serotonin 5-HT3 receptors are mediators of the excitatory effects of cholecystokinin and 5-HT, respectively, on pancreatic vagal afferent discharge | Activation of cholecystokinin (CCK 1) and serotonin (5-HT 3) receptors increases the discharge of pancreatic vagal afferents.
Mussa BM, Sartor DM, Verberne AJ. | 01/21/2010 |
| Report effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation. | Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation.
Wu SV, Harikumar KG, Burgess RJ, Reeve JR Jr, Miller LJ., Free PMC Article | 01/21/2010 |
| Activation of high-affinity CCK(A) receptors elicits Ca(2+) oscillations, whereas stimulation of low-affinity CCK(A) receptors evokes a sustained Ca(2+) plateau; these modes are mediated through L-type Ca(2+) channel and involve G(q) protein. | Characterization of CCK(A) receptor affinity states and Ca(2+) signal transduction in vagal nodose ganglia.
Lankisch TO, Tsunoda Y, Lu Y, Owyang C. | 01/21/2010 |
| None of the three known phases of the febrile response of rats to lipopolysaccharides requires the CCK-A receptor. | Role for the cholecystokinin-A receptor in fever: a study of a mutant rat strain and a pharmacological analysis.
Ivanov AI, Kulchitsky VA, Romanovsky AA., Free PMC Article | 01/21/2010 |
| Taste preference in Otsuka Long-Evans Tokushima fatty (OLETF) rats with deficiency of this receptor. | Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats.
De Jonghe BC, Hajnal A, Covasa M. | 01/21/2010 |