| Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. | Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Tan W, Li Y, Ma L, Fu X, Long Q, Yan F, Li W, Liu X, Ding H, Wang Y, Zhang W., Free PMC Article | 03/8/2024 |
| Long-term culture induces Bax-dependent apoptosis in rat preimplantation embryos. | Long-term culture induces Bax-dependent apoptosis in rat preimplantation embryos.
Nakamura K, Seno M, Yoshimura Y, Suzuki O. | 02/7/2024 |
| Exploration of the Protective Mechanism of Bax Removal against Ischemia Reperfusion Injury of Skin Flap through the p38 Mitogen-Activated Protein Kinase Pathway. | Exploration of the Protective Mechanism of Bax Removal against Ischemia Reperfusion Injury of Skin Flap through the p38 Mitogen-Activated Protein Kinase Pathway.
Wang Y, Wu Y, Wang P, Luo J, Rui Y., Free PMC Article | 11/12/2022 |
| Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-kappaB, TGF-beta, and BAX and Bcl-2 gene expression. | Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression.
Awad AS, Elariny HA, Sallam AS. | 02/26/2022 |
| Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus. | Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus.
Sklifasovskaya AP, Blagonravov ML, Ryabinina AY, Azova MM, Goryachev VA. | 02/12/2022 |
| The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus. | The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus.
Kuchmerovska T, Guzyk M, Tykhonenko T, Yanitska L, Pryvrotska I, Diakun K. | 11/27/2021 |
| Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats. | Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats.
Li SY, Wang CY, Zhao JJ, Long CY, Xiao YX, Tang XB, Yuan ZW, Bai YZ. | 09/25/2021 |
| Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway. | Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway.
Serrya MS, Nader MA, Abdelmageed ME. | 07/31/2021 |
| Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats. | Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.
Arab-Nozari M, Ahangar N, Mohammadi E, Lorigooini Z, Shokrzadeh M, Amiri FT, Shaki F. | 05/22/2021 |
| Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-alpha and TGF-beta expression. | Chitosan protects liver against ischemia-reperfusion injury via regulating Bcl-2/Bax, TNF-α and TGF-β expression.
Saleh H, El-Shorbagy HM. | 04/13/2021 |
| Beclin 1 was shown to interact with active caspase-3 and Bax. These results suggest that the increase in Beclin 1 is directly related to the rise of pro-apoptotic proteins, which could promote the apoptotic process during oocyte elimination. | Beclin 1 Interacts With Active Caspase-3 and Bax in Oocytes From Atretic Follicles in the Rat Ovary.
Escobar ML, Echeverria OM, Palacios-Martínez S, Juárez-Chavero S, Sánchez-Sánchez L, Vázquez-Nin GH., Free PMC Article | 06/27/2020 |
| Bax can be a novel target for the antiapoptotic effects of KPC1 on I/R-induced cardiomyocyte apoptosis and render mechanistic penetration into at least a subset of the mitochondrial effects of KPC1. | KPC1 alleviates hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte cells though BAX degradation.
Yuan Y, Wang YY, Liu X, Luo B, Zhang L, Zheng F, Li XY, Guo LY, Wang L, Jiang M, Pan YM, Yan YW, Yang JY, Chen SY, Wang JN, Tang JM., Free PMC Article | 06/13/2020 |
| Studied the potential protective activity of vitamin K2 against 6-OHDA induced apoptosis thru Bcl2-associated X protein (bax) and caspase-3 pathways. | Protective effects of vitamin K2 on 6-OHDA-induced apoptosis in PC12 cells through modulation bax and caspase-3 activation.
Ramazani E, Fereidoni M, Tayarani-Najaran Z. | 05/2/2020 |
| EtOH exacerbates Mn-induced neurobehavioral deficits, oxidative stress, and apoptosis induction via the regulation of p53, caspase-3, and Bax/Bcl-2 ratio-dependent pathway in rat striatum. | Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway.
Nkpaa KW, Awogbindin IO, Amadi BA, Abolaji AO, Adedara IA, Wegwu MO, Farombi EO. | 12/28/2019 |
| the expression levels of Bax mRNA and protein were reduced in the three tanshinone groups in a dose-sensitive manner compared to those in the blank and saline groups | Tanshinone modulates the expression of Bcl-2 and Bax in cardiomyocytes and has a protective effect in a rat model of myocardial ischemia-reperfusion.
Guo R, Li G. | 07/27/2019 |
| it is concluded that dihydromyricetin exerted a protective effect on fatty liver through NFkappaB/p53/Bax signaling pathways in a rat model. | Protective effect of dihydromyricetin revents fatty liver through nuclear factor‑κB/p53/B‑cell lymphoma 2‑associated X protein signaling pathways in a rat model.
Guo L, Zhang H, Yan X., Free PMC Article | 05/25/2019 |
| Overexpression of E50K-mutated optineurin triggered BDNF deficiency, leading to Bax activation in a retinal photoreceptor cell line. | Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line.
Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK., Free PMC Article | 01/5/2019 |
| The expression of Bax and Bcl-2 after ligation of the parotid gland is closely related to the process of the parotid gland atrophy. | Role of Bcl-2 and Bax in parotid gland atrophy.
Zuo JH, Sun CH, Gao H, Wang LF, Zhu YH. | 08/18/2018 |
| Treatment of ellagic acid resulted in increased neuron viability, cell nuclear integrity, and the ratio of Bcl-2/Bax expression in the primary cultured neuron model. | Ellagic acid protects against neuron damage in ischemic stroke through regulating the ratio of Bcl-2/Bax expression.
Liu QS, Deng R, Li S, Li X, Li K, Kebaituli G, Li X, Liu R. | 05/12/2018 |
| Results demonstrate that inflammation regulates Bax expression that subsequently contributes to the nigrostriatal dopaminergic neurodegeneration. | Inflammation and B-cell Lymphoma-2 Associated X Protein Regulate Zinc-Induced Apoptotic Degeneration of Rat Nigrostriatal Dopaminergic Neurons.
Chauhan AK, Mittra N, Kumar V, Patel DK, Singh C. | 01/27/2018 |
| results revealed that NaNO2 significantly increased serum tumor necrosis factor-alpha, C-reactive protein, heat shock proteins-70, vascular endothelial growth factor, and Interleukin 6. Moreover, transforming growth factor-beta, hypoxia-inducible factor, Smad-2, Protein Kinase B (AKT), and Bax were overexpressed, whereas Bcl2 protein was downregulated compared with the normoxic group. | Downregulation of HIF1-α, Smad-2, AKT, and Bax gene expression in sodium nitrite-induced lung injury via some antioxidants.
Kadry MO, Ali HM. | 12/23/2017 |
| hypoxia significantly decreased hemoglobin concentration, while increased expressions of HIF, Bax, Smad-2, TGF-beta, and AKT. | Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-α, TGF-β, Smad-2, and AKT pathways.
Al-Rasheed NM, Fadda LM, Attia HA, Ali HM, Al-Rasheed NM. | 12/16/2017 |
| These findings indicated for the first time that pretreatment of H9c2 cells with catalpol can be against H2O2-induced apoptosis, and the protective effect of catalpol involves the mitochondrial-dependent caspase pathway and is associated with increased Bcl-2 and decreased Bax expression. | Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway.
Hu LA, Sun YK, Zhang HS, Zhang JG, Hu J., Free PMC Article | 12/9/2017 |
| Bax protein content of skeletal muscle was not altered after 8 weeks of treadmill running in aging rats. | Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle.
Li FH, Yu HT, Xiao L, Liu YY. | 11/4/2017 |
| Studied the physiology of advanced oxidation protein products (AOPPs) in beta-cell destruction and dysfunction. Found exposure of cells to AOPPs induced an increase in Bax expression, caspase-3 activity, and apoptosis as well as a decrease in Bcl-2 expression. AOPP challenge rapidly increased the production of intracellular superoxide by activation of NADPH oxidases. | Advanced oxidation protein products promote NADPH oxidase-dependent β-cell destruction and dysfunction through the Bcl-2/Bax apoptotic pathway.
Liang M, Li A, Lou A, Zhang X, Chen Y, Yang L, Li Y, Yang S, Hou FF. | 08/26/2017 |