| Unveiling FRG1's DNA repair role in breast cancer. | Unveiling FRG1's DNA repair role in breast cancer.
Shubhanjali S, Mohapatra T, Khan R, Dixit M., Free PMC Article | 10/2/2024 |
| Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model. | Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model.
Khan R, Palo A, Dixit M., Free PMC Article | 02/26/2022 |
| Mutations in FRG1 and KMT2C were found to be associated with a younger age especially after correcting for tobacco smoking and sex in Chinese patients with lung adenocarcinoma. | Comprehensive analysis of age-related somatic mutation profiles in Chinese young lung adenocarcinoma patients.
Yang B, Li J, Li F, Zhou H, Shi W, Shi H, Sun S, Sun W, Wang J, Ma J, Yan X, Hu Y, Jiao S., Free PMC Article | 05/9/2020 |
| FRG1 expression is reduced in prostate adenocarcinoma tissue. FRG1 expression affects migration and invasion in AR negative prostate cancer cells through known MMPs and cytokines, which may be mediated primarily via p38 MAPK activation. | Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion.
Tiwari A, Mukherjee B, Hassan MK, Pattanaik N, Jaiswal AM, Dixit M., Free PMC Article | 08/17/2019 |
| Immunohistochemistry analysis showed reduced FRG1 levels in tumors which were supported by in silico analysis data. These findings suggest that reduction in FRG1 expression in gastric, colon and oral cavity tumor might have a role in tumor progression, by regulating cell migration and invasiveness. To elucidate a better understanding of molecular signaling involving FRG1 in angiogenesis regulation, further study is requir | Increased FSHD region gene1 expression reduces in vitro cell migration, invasion, and angiogenesis, ex vivo supported by reduced expression in tumors.
Tiwari A, Pattnaik N, Mohanty Jaiswal A, Dixit M., Free PMC Article | 06/16/2018 |
| Penetrance of FSHD1 is low for largest alleles in the range of 9-10 RUs, and lower in women than men. | Low penetrance in facioscapulohumeral muscular dystrophy type 1 with large pathological D4Z4 alleles: a cross-sectional multicenter study.
Salort-Campana E, Nguyen K, Bernard R, Jouve E, Solé G, Nadaj-Pakleza A, Niederhauser J, Charles E, Ollagnon E, Bouhour F, Sacconi S, Echaniz-Laguna A, Desnuelle C, Tranchant C, Vial C, Magdinier F, Bartoli M, Arne-Bes MC, Ferrer X, Kuntzer T, Levy N, Pouget J, Attarian S., Free PMC Article | 01/23/2016 |
| Our results demonstrate that FRG1 is a direct DUX4 transcriptional target uncovering a novel regulatory circuit contributing to Facioscapulohumeral muscular dystrophy. | Direct interplay between two candidate genes in FSHD muscular dystrophy.
Ferri G, Huichalaf CH, Caccia R, Gabellini D., Free PMC Article | 11/21/2015 |
| FRG1 mice overexpressing FHL1 showed an improvement in the dystrophic phenotype | FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).
Feeney SJ, McGrath MJ, Sriratana A, Gehrig SM, Lynch GS, D'Arcy CE, Price JT, McLean CA, Tupler R, Mitchell CA., Free PMC Article | 11/21/2015 |
| Study showed that the variability in clinical severity of facioscapulohumeral muscular dystrophy in FSHD1 and FSHD2 individuals is dependent on individual differences in susceptibility to D4Z4 hypomethylation. | Inter-individual differences in CpG methylation at D4Z4 correlate with clinical variability in FSHD1 and FSHD2.
Lemmers RJ, Goeman JJ, van der Vliet PJ, van Nieuwenhuizen MP, Balog J, Vos-Versteeg M, Camano P, Ramos Arroyo MA, Jerico I, Rogers MT, Miller DG, Upadhyaya M, Verschuuren JJ, Lopez de Munain Arregui A, van Engelen BG, Padberg GW, Sacconi S, Tawil R, Tapscott SJ, Bakker B, van der Maarel SM., Free PMC Article | 07/25/2015 |
| This study suggests a novel role of FRG1 as epigenetic regulator of muscle differentiation and indicates that Suv4-20h1 has a gene-specific function in myogenesis. | FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.
Neguembor MV, Xynos A, Onorati MC, Caccia R, Bortolanza S, Godio C, Pistoni M, Corona DF, Schotta G, Gabellini D. | 04/26/2014 |
| new insights into the gene deregulation characterizing both FSHD-1 and FSHD-2, in which miRNAs may play a role | Expression profiling of FSHD-1 and FSHD-2 cells during myogenic differentiation evidences common and distinctive gene dysregulation patterns.
Cheli S, François S, Bodega B, Ferrari F, Tenedini E, Roncaglia E, Ferrari S, Ginelli E, Meneveri R., Free PMC Article | 10/22/2011 |
| depressed myoblast proliferation may contribute to the pathology of mice overexpressing FRG1 and may play a part in facioscapulohumeral muscular dystrophy | Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.
Chen SC, Frett E, Marx J, Bosnakovski D, Reed X, Kyba M, Kennedy BK., Free PMC Article | 10/22/2011 |
| These data provide the first biochemical activities (actin binding and RNA binding) for human FRG1 and the characterization of the endogenous human FRG1, together indicating that FRG1 is involved in multiple aspects of RNA biogenesis. | Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein.
Sun CY, van Koningsbruggen S, Long SW, Straasheijm K, Klooster R, Jones TI, Bellini M, Levesque L, Brieher WM, van der Maarel SM, Jones PL., Free PMC Article | 09/24/2011 |
| in muscle FRG1 is a developmentally regulated sarcomeric protein suggesting FRG1 may perform a muscle-specific function | Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein.
Hanel ML, Sun CY, Jones TI, Long SW, Zanotti S, Milner D, Jones PL., Free PMC Article | 05/28/2011 |
| study compared chromatin structure & tridimensional interaction of the D4Z4 array and FRG1 gene promoter, and FRG1 expression, in control and FSHD cells | Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation.
Bodega B, Ramirez GD, Grasser F, Cheli S, Brunelli S, Mora M, Meneveri R, Marozzi A, Mueller S, Battaglioli E, Ginelli E., Free PMC Article | 01/21/2010 |
| Data show that frg1 is expressed in and essential for the development of the tadpole musculature, and suggest that maintenance of normal FRG1 levels is critical for proper muscle development in frogs and humans. | Muscular dystrophy candidate gene FRG1 is critical for muscle development.
Hanel ML, Wuebbles RD, Jones PL., Free PMC Article | 01/21/2010 |
| differently from normal myoblasts, the 4qA/B marker interacted directly with the promoters of the FRG1 and ANT1 genes in Facio-Scapulo-Humeral Dystrophy cells | A functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy.
Pirozhkova I, Petrov A, Dmitriev P, Laoudj D, Lipinski M, Vassetzky Y., Free PMC Article | 01/21/2010 |
| FRG1 transgenic mice develop a muscular dystrophy with features characteristic of the human disease; by contrast, FRG2 and ANT1 transgenic mice seem normal | Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1.
Gabellini D, D'Antona G, Moggio M, Prelle A, Zecca C, Adami R, Angeletti B, Ciscato P, Pellegrino MA, Bottinelli R, Green MR, Tupler R. | 01/21/2010 |