| Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis. | Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis.
Pacyna CN, Anandapadamanaban M, Loudon KW, Hay IM, Perisic O, Li R, Byrne M, Allen L, Roberts K, Hooks Y, Warren AY, Stewart GD, Clatworthy MR, Teichmann SA, Behjati S, Campbell PJ, Williams RL, Mitchell TJ., Free PMC Article | 11/7/2024 |
| Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway. | Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway.
Xue Z, Liu J, Xing W, Mu F, Wu Y, Zhao J, Liu X, Wang D, Wang J, Li X, Wang J, Huang B., Free PMC Article | 10/20/2024 |
| mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis. | mTOR signalling controls the formation of smooth muscle cell-derived luminal myofibroblasts during vasculitis.
Stock AT, Parsons S, Hansen JA, D'Silva DB, Starkey G, Fayed A, Lim XY, D'Costa R, Gordon CL, Wicks IP., Free PMC Article | 10/18/2024 |
| Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway. | Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway.
Huang Y, Yue S, Yan Z, Liu Y, Qiao J, Zhang M, Dong Y, Zheng J. | 10/17/2024 |
| Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target. | Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target.
Azimzadeh M, Cheah PS, Ling KH. | 10/16/2024 |
| Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain. | Assembly of mTORC3 Involves Binding of ETV7 to Two Separate Sequences in the mTOR Kinase Domain.
Zhan J, Harwood F, Have ST, Lamond A, Phillips AH, Kriwacki RW, Halder P, Cardone M, Grosveld GC., Free PMC Article | 10/4/2024 |
| Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice. | Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Witucki Ł, Jakubowski H. | 10/3/2024 |
| The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway. | The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway.
Li S, Su Y, Tian J, Wang K, Wang X, Ding L, Li C., Free PMC Article | 09/25/2024 |
| Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer. | Protein kinase C iota promotes glycolysis via PI3K/AKT/mTOR signalling in high grade serous ovarian cancer.
Tyagi K, Roy A, Mandal S. | 09/23/2024 |
| MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR. | MiR-199a-3p regulates HCT-8 cell autophagy and apoptosis in response to Cryptosporidium parvum infection by targeting MTOR.
Wu S, Shao T, Xie J, Li J, Sun L, Zhang Y, Zhao L, Wang L, Li X, Zhang L, Wang R., Free PMC Article | 09/10/2024 |
| mTOR gene variant rs2295080 might be a risk factor for atherosclerosis in Iranian women with type 2 diabetes mellitus. | mTOR gene variant rs2295080 might be a risk factor for atherosclerosis in Iranian women with type 2 diabetes mellitus.
Zare A, Khosropanah S, Daryabor G, Doroudchi M., Free PMC Article | 09/10/2024 |
| Erythropoietin enhances iron bioavailability in HepG2 cells by downregulating hepcidin through mTOR, C/EBPalpha and HIF-1alpha. | Erythropoietin enhances iron bioavailability in HepG2 cells by downregulating hepcidin through mTOR, C/EBPα and HIF-1α.
Maltaneri RE, Chamorro ME, Gionco SE, Nesse AB, Vittori DC. | 09/9/2024 |
| Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway. | Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway.
Yang H, Wu B, Yang Q, Tan T, Shang D, Chen J, Cao C, Xu C., Free PMC Article | 09/4/2024 |
| Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing. | Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing.
Huang X, Zeng J, Luo Y, Luo S, Li Y, Wang J., Free PMC Article | 08/29/2024 |
| Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia. | Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia.
Wei XH, Liao LY, Yin YX, Xu Q, Xie SS, Liu M, Gao LB, Chen HQ, Zhou R., Free PMC Article | 08/15/2024 |
| Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis. | Extracellular vesicle-mediated regulation of imatinib resistance in chronic myeloid leukemia via the miR-629-5p/SENP2/PI3K/AKT/mTOR axis.
Jiang Y, Xiao S, Huang S, Zhao X, Ding S, Huang Q, Xiao W, Li Z, Zhu H. | 08/1/2024 |
| MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1. | MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1.
Li X, Cheng K, Shang MD, Yang Y, Hu B, Wang X, Wei XD, Han YC, Zhang XG, Dong MH, Yang ZL, Wang JQ., Free PMC Article | 07/30/2024 |
| lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway. | lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway.
Yang G, Li Z, Dong L, Zhou F. | 07/28/2024 |
| PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer. | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer.
Li X, Li C, Guo C, Zhao Q, Cao J, Huang HY, Yue M, Xue Y, Jin Y, Hu L, Ji H. | 07/26/2024 |
| Oncogenic pseudogene DUXAP10 knockdown suppresses proliferation and invasion and induces apoptosis of papillary thyroid carcinoma cells by inhibition of Akt/mTOR pathway. | Oncogenic pseudogene DUXAP10 knockdown suppresses proliferation and invasion and induces apoptosis of papillary thyroid carcinoma cells by inhibition of Akt/mTOR pathway.
Li J, Jiang L, Liu Z, Li Y, Xu Y, Liu H. | 07/26/2024 |
| Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKalpha activation. | Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation.
Beaumont JEJ, Barbeau LMO, Ju J, Savelkouls KG, Bouwman FG, Zonneveld MI, Bronckaers A, Kampen KR, Keulers TGH, Rouschop KMA., Free PMC Article | 07/18/2024 |
| Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway. | Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway.
Wang X, Liu H, Wang Y, Wang P, Yi Y, Lin Y, Li X. | 07/18/2024 |
| Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway. | Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway.
Iranpanah A, Majnooni MB, Biganeh H, Amirian R, Rastegari-Pouyani M, Filosa R, Cheang WS, Fakhri S, Khan H. | 07/15/2024 |
| Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy. | Fibroblast growth factor 21 alleviates idiopathic pulmonary fibrosis by inhibiting PI3K-AKT-mTOR signaling and stimulating autophagy.
Qi J, Wu Y, Guo Z, Zhu S, Xiong J, Hu F, Liang X, Ye X. | 07/13/2024 |
| Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration. | Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei QY, Lu B, Wen W., | 06/25/2024 |