| Study indicates that chronic prolactin administration before kainic acid induced damage induces hippocampal neuroprotection associated with prolactin receptor and VGLUT1 overexpression. | Prolactin prevents the kainic acid-induced neuronal loss in the rat hippocampus by inducing prolactin receptor and putatively increasing the VGLUT1 overexpression.
Ortiz-Pérez A, Limón-Morales O, Rojas-Castañeda JC, Cerbón M, Picazo O. | 06/22/2019 |
| This study demonstrated that the Cultured neurons expressed mRNA for both PRL and its receptor (PRLR), and both PRL and PRLR expression levels changed after the excitotoxic insult. | Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor.
Vergara-Castañeda E, Grattan DR, Pasantes-Morales H, Pérez-Domínguez M, Cabrera-Reyes EA, Morales T, Cerbón M. | 12/24/2016 |
| Results showed that an active sexual life, with constant execution of sexual behavior, produces a sustained increase in serum PRL, prostate PRL receptors, and the pStat3 signaling pathway | Correlation of prolactin levels and PRL-receptor expression with Stat and Mapk cell signaling in the prostate of long-term sexually active rats.
Rojas-Durán F, Pascual-Mathey LI, Serrano K, Aranda-Abreu GE, Manzo J, Soto-Cid AH, Hernandez ME. | 08/29/2015 |
| PRLR signaling is required for DNA synthesis and survival of rat insulinoma cells | Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression.
Arumugam R, Fleenor D, Freemark M., Free PMC Article | 04/4/2015 |
| The cholestasis-induced changes in the intensity of prolactin receptor expression were opposite in kidney and liver cells. | Prolactine receptor expression in kidney tissue of female rats with cholestasis: the effect of hyperprolactinemia.
Aleksandrova MI, Kushnareva NS, Smirnova OV. | 02/2/2013 |
| The results demonstrate that the prolactin receptor system is altered in nonneural tissues as a result of the female's reproductive history. | Reproductive experience alters prolactin receptor expression in mammary and hepatic tissues in female rats.
Bridges RS, Scanlan VF, Lee JO, Byrnes EM., Free PMC Article | 08/4/2012 |
| PRLR mRNA was highly expressed throughout the rostral preoptic area, particularly in periventricular regions surrounding the third ventricle, and there was a high degree of colocalization of PRLR mRNA in both Gad1/Gad2 and Kiss1 mRNA-containing cells. | Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility.
Kokay IC, Petersen SL, Grattan DR. | 02/26/2011 |
| Report cross talk between prolactin and dopamine 1-like receptors in renal proximal tubular cells. | Prolactin and dopamine 1-like receptor interaction in renal proximal tubular cells.
Crambert S, Sjöberg A, Eklöf AC, Ibarra F, Holtbäck U. | 07/19/2010 |
| Expression of Prlr increases at night in the rat pineal gland ~10-fold. | Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, Rangel ZG, Munson PJ, Klein DC., Free PMC Article | 07/16/2009 |
| Data support the concept that a maternal aggressive experience, while acutely altering PRL secretion, fails to affect medial preoptic area PRL-R(L) mRNA expression. | Circulating prolactin, MPOA prolactin receptor expression and maternal aggression in lactating rats.
Consiglio AR, Bridges RS., Free PMC Article | 01/21/2010 |
| Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion. | Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion.
Patel OV, Zakrzewska E, Maple RL, Baer LA, Ronca AE, Wade CE, Plaut K. | 01/21/2010 |
| These observations suggest that macrophage functions are regulated by an endogenous dopaminergic tone. Our data also suggest that both PRL and dopamine exert their action by acting directly on the peritoneal macrophage. | In vitro macrophage activity: biphasic effect of prolactin and indirect evidence of dopaminergic modulation.
Carvalho-Freitas MI, Rodrigues-Costa EC, Nasello AG, Palermo-Neto J, Felicio LF. | 01/21/2010 |
| Results show that metyrapone-induced corticosterone deficiency impairs Leydig cell insulin and prolactin, but not LH, receptors, and their mRNA expression and the response of Leydig cells to LH/PRL/insulin on testosterone production. | Differential effect of corticosterone deficiency on the expression of LH, prolactin and insulin receptors on rat Leydig cells.
Parthasarathy C, Balasubramanian K. | 01/21/2010 |
| Hypergravity-induced downregulation of prolactin receptor (PRLR) is not directly triggered by deranged distribution of PRLR isoforms. | Tissue-specific variation in expression of prolactin receptor gene subtypes in hypergravity-exposed rats.
Patel OV, Maple RL, Baer LA, Ronca A, Wade CE, Plaut K. | 01/21/2010 |
| Expression of PRLR gene in the female and male rat brains increases during postnatal development due to the transcriptional activation of the E1(4) first exon. | Developmental changes in the expression levels of alternative first exons of prolactin receptor gene in rat brain.
Kobayashi M, Suzuki M, Saito TR, Tanaka M. | 01/21/2010 |
| residual agonism can be abolished either by further disrupting hormone site 2-receptor contacts by N-terminal deletion, as in Del1-9-G129R-human prolactin (hPRL), or by stabilizing hPRL and constraining its intrinsic flexibility, as in G129V-hPRL | Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.
Jomain JB, Tallet E, Broutin I, Hoos S, van Agthoven J, Ducruix A, Kelly PA, Kragelund BB, England P, Goffin V. | 01/21/2010 |
| Region-specific promoter usage in prolactin receptor mRNA transcription, and involvement of oestrogens in the regulation of Exon1-3 mRNA expression in the brain and pituitary gland. | Region-specific expression and hormonal regulation of the first exon variants of rat prolactin receptor mRNA in rat brain and anterior pituitary gland.
Nogami H, Hoshino R, Ogasawara K, Miyamoto S, Hisano S. | 01/21/2010 |
| The expression of both forms of prolactin receptor mRNA in nigrostriatal areas may help to support the hypothesis that prolactin has direct actions on these brain regions | Detection of prolactin receptor mRNA in the corpus striatum and substantia nigra of the rat.
Pi X, Voogt JL, Grattan DR. | 01/21/2010 |
| the loss of responsiveness to prolactin occurring during lactation is not due to down regulation of long-form PRL-R gene expression on tuberoinfundibular neurones | Expression of mRNA for prolactin receptor (long form) in dopamine and pro-opiomelanocortin neurones in the arcuate nucleus of non-pregnant and lactating rats.
Kokay IC, Grattan DR. | 01/21/2010 |
| PRL and PRL receptors may play significant modulatory roles during immune-inflammatory processes | Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts.
Corbacho AM, Macotela Y, Nava G, Eiserich JP, Cross CE, Martínez de la Escalera G, Clapp C. | 01/21/2010 |
| The expression of prolactin receptor in the paraventricular nucleus may be important in suppressing gastric ulceration. | Gastric ulceration and expression of prolactin receptor in the brain in Hatano high- and low-avoidance rats.
Asai S, Ohta R, Fujikawa T, Sakai RR, Shirota M, Ogata M, Watanabe G, Taya K. | 01/21/2010 |
| Level of expression in the preoptic area is determined by addition of progesterone and estradiol mimicking pregnancy. | Steroid-induced alterations in mRNA expression of the long form of the prolactin receptor in the medial preoptic area of female rats: Effects of exposure to a pregnancy-like regimen of progesterone and estradiol.
Bridges RS, Hays LE. | 01/21/2010 |
| time-course of changes in PRL-R mRNA levels during pregnancy and/or lactation, and determination of relative levels of the two forms (short and/or long form) of receptor mRNA in specific brain regions | Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation.
Augustine RA, Kokay IC, Andrews ZB, Ladyman SR, Grattan DR. | 01/21/2010 |
| Hypoxia ischemia induces a robust activation of the prolactin receptor in regions of the cerebral cortex affected by injury. | Prolactin is involved in glial responses following a focal injury to the juvenile rat brain.
Möderscheim TA, Gorba T, Pathipati P, Kokay IC, Grattan DR, Williams CE, Scheepens A. | 01/21/2010 |
| Estrogen differentially regulates expression of the PRL-R mRNA in the different brain regions by increasing the utilization of PRL-R gene promoters 1A and 1C in the female rat. | Promoter usage and estrogen regulation of prolactin receptor gene in the brain of the female rat.
Pi X, Zhang B, Li J, Voogt JL. | 01/21/2010 |