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    IL27 interleukin 27 [ Homo sapiens (human) ]

    Gene ID: 246778, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications.

    Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications.
    Luo YH, Zhang YY, Li MQ, Zhang XY, Zheng ZM.

    10/29/2024
    IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study.

    IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study.
    Jing Q, Liu X, Lv Z, Xue D., Free PMC Article

    10/11/2024
    Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion.

    Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion.
    Korobova ZR, Arsentieva NA, Santoni A, Totolian AA., Free PMC Article

    07/31/2024
    Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages.

    Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages.
    Hernández-Sarmiento LJ, Tamayo-Molina YS, Valdés-López JF, Urcuqui-Inchima S., Free PMC Article

    07/5/2024
    The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.

    The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.
    Gao L, Xiong YJ, Liang YX, Huang PF, Liu S, Xiao Y, Huang Q, Wang H, Wu HM., Free PMC Article

    05/3/2024
    Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.

    Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.
    Martin E, Winter S, Garcin C, Tanita K, Hoshino A, Lenoir C, Fournier B, Migaud M, Boutboul D, Simonin M, Fernandes A, Bastard P, Le Voyer T, Roupie AL, Ben Ahmed Y, Leruez-Ville M, Burgard M, Rao G, Ma CS, Masson C, Soudais C, Picard C, Bustamante J, Tangye SG, Cheikh N, Seppänen M, Puel A, Daly M, Casanova JL, Neven B, Fischer A, Latour S.

    04/25/2024
    Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.

    Association of serum IL-30 and soluble GP130 with the risk of psoriasis vulgaris.
    Shehata RR, Atta SA, Fatma AS, Aml RA, Gomaa AS.

    04/19/2024
    IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans.

    IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans.
    Liu W, Zhang Y, Chen X.

    03/29/2024
    IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.

    IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.
    Bradford SD, Ryan KJ, Divens AM, Povroznik JM, Bonigala S, Robinson CM., Free PMC Article

    02/28/2024
    Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.

    Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.
    Li P, Pu S, Yi J, Li X, Wu Q, Yang C, Kang M, Peng F, Zhou Z.

    02/13/2024
    Research Progress of Interleukin-27 in Inflammatory Bowel Disease.

    Research Progress of Interleukin-27 in Inflammatory Bowel Disease.
    Wang Q, Chen F, Peng Y, Yi X, He Y, Shi Y.

    02/7/2024
    Investigation of the role of interleukin 27 in the immune regulation of Treg and Th17 cells in neurosyphilis patients.

    Investigation of the role of interleukin 27 in the immune regulation of Treg and Th17 cells in neurosyphilis patients.
    Zhao W, Luo H.

    02/5/2024
    Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways.

    Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways.
    Ciummo SL, Sorrentino C, Fieni C, Di Carlo E., Free PMC Article

    12/20/2023
    Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.

    Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.
    Pagano G, Botana IF, Wierz M, Roessner PM, Ioannou N, Zhou X, Al-Hity G, Borne C, Gargiulo E, Gonder S, Qu B, Stamatopoulos B, Ramsay AG, Seiffert M, Largeot A, Moussay E, Paggetti J., Free PMC Article

    11/7/2023
    Identification of IL-27 as a novel regulator of major histocompatibility complex class I and class II expression, antigen presentation, and processing in intestinal epithelial cells.

    Identification of IL-27 as a novel regulator of major histocompatibility complex class I and class II expression, antigen presentation, and processing in intestinal epithelial cells.
    Diegelmann J, Brand S., Free PMC Article

    11/2/2023
    Association of IL-17 and IL-27 polymorphisms with susceptibility to recurrent pregnancy loss and pre-eclampsia: A systematic review and meta-analysis.

    Association of IL-17 and IL-27 polymorphisms with susceptibility to recurrent pregnancy loss and pre-eclampsia: A systematic review and meta-analysis.
    Ma Y, Ma M, Ye S, Liu Y, Zhao X, Wang Y., Free PMC Article

    11/1/2023
    Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFbeta1 and IL-27.

    Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27.
    Riehl DR, Sharma A, Roewe J, Murke F, Ruppert C, Eming SA, Bopp T, Kleinert H, Radsak MP, Colucci G, Subramaniam S, Reinhardt C, Giebel B, Prinz I, Guenther A, Strand D, Gunzer M, Waisman A, Ward PA, Ruf W, Schäfer K, Bosmann M., Free PMC Article

    09/29/2023
    Association between interleukin-27 gene polymorphisms and Plasmodium falciparum Malaria.

    Association between interleukin-27 gene polymorphisms and Plasmodium falciparum Malaria.
    Aljarba NH, Al-Anazi MR, Al-Hazani TM, Shafeai MI, Rudiny FH, Motaen AM, Bin Dajem SM, Alothaid H, Alghamdi J, Alkahtani S, Al-Qahtani AA., Free PMC Article

    09/7/2023
    Constitutive expression of interleukin-27 diminishes proinflammatory cytokine production without impairing effector function of engineered T cells.

    Constitutive expression of interleukin-27 diminishes proinflammatory cytokine production without impairing effector function of engineered T cells.
    Afsahi A, Burchett R, Baker CL, Moore AE, Bramson JL.

    08/2/2023
    IL-27 enhances peripheral B cell glycolysis of rheumatoid arthritis patients via activating mTOR signaling.

    IL-27 enhances peripheral B cell glycolysis of rheumatoid arthritis patients via activating mTOR signaling.
    Qi J, Liu J, Zhao X, Huang H, Tang Y, Li X.

    07/26/2023
    Antiviral response and immunopathogenesis of interleukin 27 in COVID-19.

    Antiviral response and immunopathogenesis of interleukin 27 in COVID-19.
    Valdés-López JF, Urcuqui-Inchima S., Free PMC Article

    06/22/2023
    Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis.

    Defective Induction of IL-27-Mediated Immunoregulation by Myeloid DCs in Multiple Sclerosis.
    von Glehn F, Pochet N, Thapa B, Raheja R, Mazzola MA, Jangi S, Beynon V, Huang J, Farias AS, Paul A, Santos LMB, Gandhi R, Murugaiyan G, Weiner HL, Baecher-Allan CM., Free PMC Article

    05/19/2023
    Association of IL-27 gene rs153109 and rs17855750 polymorphisms with preeclampsia susceptibility and severity: Meta-analysis and trial sequential analysis.

    Association of IL-27 gene rs153109 and rs17855750 polymorphisms with preeclampsia susceptibility and severity: Meta-analysis and trial sequential analysis.
    Wang F, Wen E, Huang Y, Wen Z, Liu Z., Free PMC Article

    05/8/2023
    Elevated expression of interleukin-27, IL-35, and decreased IL-12 in patients with thyroid-associated ophthalmopathy.

    Elevated expression of interleukin-27, IL-35, and decreased IL-12 in patients with thyroid-associated ophthalmopathy.
    Zhang P, Zhang X, Xu F, Xu W, Zhu H.

    03/30/2023
    IL-27 inhibits anti- Mycobacterium tuberculosis innate immune activity of primary human macrophages.

    IL-27 inhibits anti- Mycobacterium tuberculosis innate immune activity of primary human macrophages.
    Gollnick H, Barber J, Wilkinson RJ, Newton S, Garg A., Free PMC Article

    03/16/2023
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