| Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders. | Phenotypic and genotypic landscape of PROKR2 in neuroendocrine disorders.
Martinez-Mayer J, Perez-Millan MI., Free PMC Article | 03/1/2023 |
| Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2. | Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Casella I, Ambrosio C. | 01/22/2022 |
| Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies. | Pressure Overload-Mediated Sustained PKR2 (Prokineticin-2 Receptor) Signaling in Cardiomyocytes Contributes to Cardiac Hypertrophy and Endotheliopathies.
Demir F, Urayama K, Audebrand A, Toprak-Semiz A, Steenman M, Kurose H, Nebigil CG. | 01/15/2022 |
| Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network. | Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.
Morris EL, Patton AP, Chesham JE, Crisp A, Adamson A, Hastings MH., Free PMC Article | 12/18/2021 |
| The regulatory G protein signaling complex, Gbeta5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion. | The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion.
Wang Q, Henry TAN, Pronin AN, Jang GF, Lubaczeuski C, Crabb JW, Bernal-Mizrachi E, Slepak VZ., Free PMC Article | 12/26/2020 |
| The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons. | The PROK2/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons.
Wen Y, Zhang Z, Li Z, Liu G, Tao G, Song X, Xu Z, Shang Z, Guo T, Su Z, Chen H, You Y, Li J, Yang Z. | 10/10/2020 |
| infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells. | Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N. | 07/27/2019 |
| The sexually dimorphic pattern of Prokr2 expression indicates differential roles in reproductive function and, potentially, in other physiological systems. | Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model.
Mohsen Z, Sim H, Garcia-Galiano D, Han X, Bellefontaine N, Saunders TL, Elias CF., Free PMC Article | 06/30/2018 |
| This study presents the first experimental evidence indicating a molecular interaction between anosmin 1 and PKR2. A truncated anosmin 1 protein comprising the first three domains of the protein interacts with the second extracellular loop of PKR2, involved in PK2 binding. | Anosmin 1 Interacts with the Prokineticin Receptor 2 In Vitro Indicating a Molecular Link Between Both Proteins in the Pathogenesis of Kallmann Syndrome.
Murcia-Belmonte V, Astillero-López V, Esteban PF. | 03/25/2017 |
| Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease. | Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
Castelli M, Amodeo G, Negri L, Lattanzi R, Maftei D, Gotti C, Pistillo F, Onnis V, Congu C, Panerai AE, Sacerdote P, Franchi S., Free PMC Article | 08/13/2016 |
| Studies indicate PK2 signaling is required for the maintenance of normal female estrous cycles. | Signaling role of prokineticin 2 on the estrous cycle of female mice.
Xiao L, Zhang C, Li X, Gong S, Hu R, Balasubramanian R, Crowley W WF Jr, Hastings MH, Zhou QY., Free PMC Article | 01/3/2015 |
| We sought to clarify the role of PROKR2 in hypothalamopituitary development through analysis of Prokr2(-/-) mice. | Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.
McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto KH, Nagano M, Shigeyoshi Y, Pfeifer M, Hulse T, Buchanan CR, Pitteloud N, Martinez-Barbera JP, Dattani MT., Free PMC Article | 05/4/2013 |
| Prokr2 is specifically expressed in the XY gonads during sex determination and fetal sexual differentiation, and knockout mice display a variable degree of compromised vasculature in the fetal testes | Prokr2-deficient mice display vascular dysmorphology of the fetal testes: potential implications for Kallmann syndrome aetiology.
Svingen T, McClelland KS, Masumoto K, Sujino M, Nagano M, Shigeyoshi Y, Koopman P. | 06/16/2012 |
| The functional characteristics of coronary endothelial cells depend on the expression of PKR1 and PKR2 levels and the divergent signaling pathways used by these receptors. | Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.
Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG. | 04/12/2010 |
| prokineticin 2 is expressed in neurons of the mouse suprachiasmatic nucleus | Efferent projections of prokineticin 2 expressing neurons in the mouse suprachiasmatic nucleus.
Zhang C, Truong KK, Zhou QY., Free PMC Article | 02/8/2010 |
| Data show that the inflammation-induced up-regulation of PK2 was significantly less in pkr1 null mice than in WT and pkr2 null mice, demonstrating a role of PKR1 in setting PK2 levels during inflammation. | The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.
Giannini E, Lattanzi R, Nicotra A, Campese AF, Grazioli P, Screpanti I, Balboni G, Salvadori S, Sacerdote P, Negri L., Free PMC Article | 01/21/2010 |
| Cardiomyocyte PKR2 signalling leads to eccentric hypertrophy in an autocrine regulation and impaired endothelial integrity in a paracrine regulation without inducing angiogenesis. | Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage.
Urayama K, Dedeoglu DB, Guilini C, Frantz S, Ertl G, Messaddeq N, Nebigil CG. | 01/21/2010 |
| All mutated PROKR2 except one (M323I) had decreased signalling activities. | PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity.
Monnier C, Dodé C, Fabre L, Teixeira L, Labesse G, Pin JP, Hardelin JP, Rondard P., Free PMC Article | 01/21/2010 |
| Results describe the identity of the prokineticin receptor 2-expressing cells in the subventricular zone/rostral migratory stream/olfactory bulb pathway in adult mice. | Prokineticin receptor 2 expression identifies migrating neuroblasts and their subventricular zone transient-amplifying progenitors in adult mice.
Puverel S, Nakatani H, Parras C, Soussi-Yanicostas N. | 01/21/2010 |
| Prokineticin 2 polypeptide (Prokr2) signaling plays a role in hypothalamic regulation of energy balance, and loss of this pathway results in physiological and behavioral responses normally only detected when mice are in negative energy balance. | Loss of prokineticin receptor 2 signaling predisposes mice to torpor.
Jethwa PH, I'Anson H, Warner A, Prosser HM, Hastings MH, Maywood ES, Ebling FJ., Free PMC Article | 01/21/2010 |
| Important role for Prokr2 in olfactory bulb neurogenesis. | Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation.
Prosser HM, Bradley A, Caldwell MA., Free PMC Article | 01/21/2010 |
| PKR2 expression was maintained over 10.5dpc with both trophoblastic and endothelial cell localisations in mice. | Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.
Hoffmann P, Feige JJ, Alfaidy N. | 01/21/2010 |
| Phenotypic analysis indicated that not Pkr1(-/-)but Pkr2(-/-)mice exhibited hypoplasia of the olfactory bulb. | Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.
Matsumoto S, Yamazaki C, Masumoto KH, Nagano M, Naito M, Soga T, Hiyama H, Matsumoto M, Takasaki J, Kamohara M, Matsuo A, Ishii H, Kobori M, Katoh M, Matsushime H, Furuichi K, Shigeyoshi Y., Free PMC Article | 01/21/2010 |
| is an essential link for coordination of circadian behavior and physiology by the suprachiasmatic nucleus, especially in defining the onset and maintenance of circadian night | Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.
Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES., Free PMC Article | 01/21/2010 |