| AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2. | Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling.
Conley JM, Watts VJ., Free PMC Article | 10/19/2013 |
| This study demonistrated that the ags3 expression increassing in rat brain cortex after traumatic brain injury. | Increased expression of AGS3 in rat brain cortex after traumatic brain injury.
Wang W, Li Q, Zou F, Yu Z, Wang Y, Lu T, Hu T, Cui G. | 09/14/2013 |
| These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration. | Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents.
Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F., Free PMC Article | 08/20/2011 |
| levels of AGS3 and USP9x are co-regulated in the prefrontal cortex of rats withdrawn from repeated cocaine treatment | Identification of a deubiquitinating enzyme as a novel AGS3-interacting protein.
Xu Z, Xia B, Gong Q, Bailey J, Groves B, Radeke M, Wood SA, Szumlinski KK, Ma D., Free PMC Article | 01/15/2011 |
| These data present AGS3, G-proteins, and mInsc as candidate proteins involved in regulating cellular stress associated with protein-processing pathologies. | Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.
Vural A, Oner S, An N, Simon V, Ma D, Blumer JB, Lanier SM., Free PMC Article | 04/12/2010 |
| AGS3 and G betagamma are hypothesized to gate the uncontrolled motivation to seek EtOH during abstinence | Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.
Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I., Free PMC Article | 01/21/2010 |
| The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. | The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.
An N, Blumer JB, Bernard ML, Lanier SM., Free PMC Article | 01/21/2010 |
| Ric-8A has a role in catalyzing guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3 | Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.
Thomas CJ, Tall GG, Adhikari A, Sprang SR., Free PMC Article | 01/21/2010 |
| Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior. | Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior.
Yao L, McFarland K, Fan P, Jiang Z, Inoue Y, Diamond I., Free PMC Article | 01/21/2010 |
| Activates heterotimeric G protein signaling in a nucleotide exchange-independent manner. | Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.
Ghosh M, Peterson YK, Lanier SM, Smrcka AV. | 01/21/2010 |
| regulated formation of a protein complex consisting of LKB1, AGS3, and G-protein, and phosphorylation of AGS3 GPR domains by LKB1, regulating the interaction of GPR-containing proteins with G-proteins | Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.
Blumer JB, Bernard ML, Peterson YK, Nezu J, Chung P, Dunican DJ, Knoblich JA, Lanier SM. | 01/21/2010 |
| residues outside of the GPR motifs strongly potentiate their binding and GDI activity toward G alpha i1 even though the amino acid sequences of these residues are not conserved among the GPR repeats | Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1.
Adhikari A, Sprang SR. | 01/21/2010 |
| The silencing AGS3, a nonreceptor activator of Gbetagamma, results in defects similar to the impairment of Gbetagamma, providing evidence that AGS3-Gbetagamma signaling in progenitors regulates apical-basal division and asymmetric cell-fate decisions. | G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors.
Sanada K, Tsai LH. | 01/21/2010 |
| results confirm a broad distribution for AGS3 which is expressed throughout the brain. | Activator of G protein signaling type 3 mRNA is widely distributed in the rat brain and is particularly abundant in the subventricular zone-olfactory bulb system of neural precursor cell proliferation, migration and differentiation.
Taymans JM, Kia HK, Langlois X. | 01/21/2010 |
| a g-protein regulator, in developmental gene expression regulation. | Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis.
Blumer JB, Chandler LJ, Lanier SM. | 01/21/2010 |
| The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested. | Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3.
Peterson YK, Bernard ML, Ma H, Hazard S 3rd, Graber SG, Lanier SM. | 12/22/2003 |