| Exosomal IRF1-loaded rat adipose-derived stem cell sheet contributes to wound healing in the diabetic foot ulcers. | Exosomal IRF1-loaded rat adipose-derived stem cell sheet contributes to wound healing in the diabetic foot ulcers.
Wu M, Tu J, Huang J, Wen H, Zeng Y, Lu Y., Free PMC Article | 04/28/2023 |
| IRF-1 protein levels gradually increased after a spinal cord injury. IRF-1 depletion decreases neuronal apoptosis. | An Up-regulation of IRF-1 After a Spinal Cord Injury: Implications for Neuronal Apoptosis.
Zhao J, Chen C, Xiao JR, Wei HF, Zhou XH, Mao XX, Zhang WD, Qian R, Chen XL, He MQ, Yu XW, Zhao J., Free PMC Article | 08/27/2016 |
| These data implicate that sublytic C5b-9 induces the expression of both p300 and IRF-1, as well as p300-dependent IRF-1 acetylation that may contribute to XAF1 gene activation and subsequent glomerular mesangial cells apoptosis. | Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation.
Qiu W, Zhou J, Zhu G, Zhao D, He F, Zhang J, Lu Y, Yu T, Liu L, Wang Y., Free PMC Article | 05/23/2015 |
| these findings identify HCN1 channels as a novel neural target for type I IFNs providing the possibility to tune neural responses | Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations.
Stadler K, Bierwirth C, Stoenica L, Battefeld A, Reetz O, Mix E, Schuchmann S, Velmans T, Rosenberger K, Bräuer AU, Lehnardt S, Nitsch R, Budt M, Wolff T, Kole MH, Strauss U. | 09/27/2014 |
| The Irf-1 overexpression-induced proliferation of VSMCs, the up-regulation of cyclin E/CDK2 and the acceleration of cell cycle progression are associated with ROS/Erk1/2 signaling pathway under high glucose conditions. | Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells.
Zhang X, Liu L, Chen C, Chi YL, Yang XQ, Xu Y, Li XT, Guo SL, Xiong SH, Shen MR, Sun Y, Zhang CS, Hu KM., Free PMC Article | 05/10/2014 |
| Overexpression of Irf-1 accelerated the proliferation of VSMCs, and down-regulation of Irf-1 depressed the proliferative ability of VSMCs under high-glucose conditions, indicating that Irf-1 was a positive regulator for high glucose-induced proliferation. | Interferon regulatory factor-1 as a positive regulator for high glucose-induced proliferation of vascular smooth muscle cells.
Yu S, Xi Z, Hai-Yan C, Ya-Li C, Shao-Hu X, Chuan-Sen Z, Xiang-Qun Y, Jin-Ping G, Hai-Yan L, Lei D. | 10/20/2012 |
| Nerve growth factor can improve the sodium current in PC-12 cells by regulating IRF1. | [Nerve growth factor increases sodium current via interferon regulatory factor-1 pathway in rat pheochromocytoma cells].
Zhu Y, Pan P, Tan H, Hu C. | 10/20/2012 |
| Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation. | Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Liu L, Qiu W, Wang H, Li Y, Zhou J, Xia M, Shan K, Pang R, Zhou Y, Zhao D, Wang Y., Free PMC Article | 07/14/2012 |
| CCL5 induction in aorta and smooth muscle cells is mediated by IRF-1 while activation of p38 MAPK signaling inhibits CCL5 and IP-10 expression. | Regulation of CCL5 expression in smooth muscle cells following arterial injury.
Liu H, Ning H, Men H, Hou R, Fu M, Zhang H, Liu J., Free PMC Article | 06/9/2012 |
| Data show that IRF1 and IRF8 mediate interferon-gamma signaling leading to oligodendroglial progenitor cell apoptosis. | Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells.
Horiuchi M, Itoh A, Pleasure D, Ozato K, Itoh T., Free PMC Article | 06/4/2011 |
| The conclusion of this study is that STAT1 and IRF-1 function as components of the signaling pathway that mediates IFN-gamma-induced oligodendrocyte progenitor cell death. | STAT1/IRF-1 signaling pathway mediates the injurious effect of interferon-gamma on oligodendrocyte progenitor cells.
Wang Y, Ren Z, Tao D, Tilwalli S, Goswami R, Balabanov R. | 02/22/2010 |
| IL-13 down-regulates the cytokine-induced iNOS transcription by decreasing iNOS specific IRF-1/ISRE binding activity | Transcriptional suppression of cytokine-induced iNOS gene expression by IL-13 through IRF-1/ISRE signaling.
Shao L, Guo Z, Geller DA., Free PMC Article | 01/21/2010 |