| Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A. | Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A.
Zhao S, Dong Y, Li Y, Wang Z, Chen Y, Dong Y., Free PMC Article | 01/31/2024 |
| Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice. | Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice.
Meng Z, Guo S, Dong X, Wang Q, Hu D, Liu X, Jiang Y, Ji L, Zhang J, Zhu W, Zhou W, Song W. | 01/11/2024 |
| The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice. | The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.
Ma X, Wang J, Wang L, Yan L, Liu Y, Ma W, Ji P, Zhang L, Liu G., Free PMC Article | 05/5/2023 |
| Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis. | Melatonin Type 2 Receptor Activation Regulates Blue Light Exposure-Induced Mouse Corneal Epithelial Damage by Modulating Impaired Autophagy and Apoptosis.
Jin R, Li Y, Jin H, Yoon HS, Choi JS, Kim J, Yoon HJ, Yoon KC., Free PMC Article | 10/22/2022 |
| Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction. | Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.
Thomson DM, Mitchell EJ, Openshaw RL, Pratt JA, Morris BJ., Free PMC Article | 02/12/2022 |
| Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT2 receptors. | Dysfunction of serotonergic activity and emotional responses across the light-dark cycle in mice lacking melatonin MT(2) receptors.
Comai S, De Gregorio D, Posa L, Ochoa-Sanchez R, Bedini A, Gobbi G. | 08/21/2021 |
| Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus. | Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT(2) receptor- Ca(2+) -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.
Wang Q, Zhu D, Ping S, Li C, Pang K, Zhu S, Zhang J, Comai S, Sun J. | 07/31/2021 |
| Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice. | Nociceptive responses in melatonin MT(2) receptor knockout mice compared to MT(1) and double MT(1) /MT(2) receptor knockout mice.
Posa L, Lopez-Canul M, Rullo L, De Gregorio D, Dominguez-Lopez S, Kaba Aboud M, Caputi FF, Candeletti S, Romualdi P, Gobbi G. | 07/31/2021 |
| Changes in melatonin receptor expression in a murine model of glaucoma. | Changes in melatonin receptor expression in a murine model of glaucoma.
Martínez-Águila A, Fonseca B, Pérez de Lara MJ, Miras-Portugal MT, Gómez-Villafuertes R, Carracedo G, Pintor J., Free PMC Article | 07/3/2021 |
| Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5-HT2C receptor heteromers in mouse brain. | Pharmacological evidence for transactivation within melatonin MT(2) and serotonin 5-HT(2C) receptor heteromers in mouse brain.
Gerbier R, Ndiaye-Lobry D, Martinez de Morentin PB, Cecon E, Heisler LK, Delagrange P, Gbahou F, Jockers R. | 06/19/2021 |
| found in The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and endolymphatic sac epithelial cells | Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.
Takumida M, Anniko M. | 03/7/2020 |
| MT1/MT2 receptors activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. | Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J. | 12/21/2019 |
| MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations. | MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
Klosen P, Lapmanee S, Schuster C, Guardiola B, Hicks D, Pevet P, Felder-Schmittbuhl MP. | 12/21/2019 |
| study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease. | Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.
Han D, Wang Y, Chen J, Zhang J, Yu P, Zhang R, Li S, Tao B, Wang Y, Qiu Y, Xu M, Gao E, Cao F. | 12/21/2019 |
| These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis. | Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
Gao Y, Wu X, Zhao S, Zhang Y, Ma H, Yang Z, Yang W, Zhao C, Wang L, Zhang Q., Free PMC Article | 05/18/2019 |
| Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum. | Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
Benleulmi-Chaachoua A, Hegron A, Le Boulch M, Karamitri A, Wierzbicka M, Wong V, Stagljar I, Delagrange P, Ahmad R, Jockers R., Free PMC Article | 11/10/2018 |
| In the present study, the mRNA expression of the two mouse insulin genes Ins1 and Ins2 was investigated in MIN6 cells treated with different concentrations of melatonin, and insulin secretion was detected under the same conditions. Following the overexpression or silencing of MTNR1B, the activities of components of the MAPK signaling pathway | Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway.
Li Y, Wu H, Liu N, Cao X, Yang Z, Lu B, Hu R, Wang X, Wen J. | 07/21/2018 |
| identifying pineal-derived melatonin as a regulator of bone mass through MT2 receptors, this study expands the role played by tryptophan derivatives in the regulation of bone mass and underscores its therapeutic relevance in postmenopausal osteoporosis | Regulation of bone mass through pineal-derived melatonin-MT2 receptor pathway.
Sharan K, Lewis K, Furukawa T, Yadav VK., Free PMC Article | 04/21/2018 |
| Ecto-5'-nucleotidase mRNA levels were found to be diminished in both MT1 and MT1/2 knockout mice. | Melatonin receptor deficiency decreases and temporally shifts ecto-5'-nucleotidase mRNA levels in mouse prosencephalon.
Homola M, Pfeffer M, Robson SC, Fischer C, Zimmermann H, Korf HW. | 05/6/2017 |
| mediates inhibition of integrin-mediated granulocyte adhesion by melatonin | Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors.
Černyšiov V, Mauricas M, Girkontaite I. | 09/10/2016 |
| The removal of MT1R or MT2R in mice abolished the daily rhythm in blood glucose levels, but produced small effects on the rhythmic expression patterns of clock genes within skeletal muscle, liver, and adipose tissue. | Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.
Owino S, Contreras-Alcantara S, Baba K, Tosini G., Free PMC Article | 07/16/2016 |
| We have shown that melatonin receptors are expressed in embryonic salivary glands, specifically during salivary gland branching morphogenesis. Melatonin inhibits branching morphogenesis independent of both apoptosis and cell proliferation. | Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology.
Obana-Koshino A, Ono H, Miura J, Sakai M, Uchida H, Nakamura W, Nohara K, Maruyama Y, Hattori A, Sakai T., Free PMC Article | 01/16/2016 |
| Melatonin attenuates oxidative stress and the associated memory impairment induced by klotho deficiency via signaling interaction between the MT2 receptor and ERK- and Nrf2-related antioxidant potential. | Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential.
Shin EJ, Chung YH, Le HL, Jeong JH, Dang DK, Nam Y, Wie MB, Nah SY, Nabeshima Y, Nabeshima T, Kim HC., Free PMC Article | 01/16/2016 |
| there is an increased proinflammatory status of mice deficient in both membrane-bound melatonin receptors reflected by altered activation of MAPK cascades and transcriptional activation of proinflammatory mediators | Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.
Kleber A, Altmeyer S, Wolf B, Wolf A, Volk T, Fink T, Kubulus D. | 07/25/2015 |
| This study demonistrated that METH-induced CPP is dependent on time of day and the presence of the MT2 receptor, suggesting a role for melatonin in METH-induced reward. | Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice.
Clough SJ, Hutchinson AJ, Hudson RL, Dubocovich ML., Free PMC Article | 01/24/2015 |