| Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish. | Hemifacial microsomia is linked to a rare homozygous variant V162I in FRK and validated in zebrafish.
Xiong J, Wang X, Fan C, Yan J, Zhu J, Cai T. | 12/15/2023 |
| FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. | FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1.
Wang Y, Wang K, Fu J, Zhang Y, Mao Y, Wang X, Wang X, Yu R, Zhou X., Free PMC Article | 12/10/2022 |
| GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK. | GATA6 activated long non-coding RNA PCAT1 maintains stemness of non-small cell lung cancer by mediating FRK.
Zang Q, Xu L, Li J, Jia H. | 08/21/2021 |
| Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas. | Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas.
Bayard Q, Caruso S, Couchy G, Rebouissou S, Bioulac Sage P, Balabaud C, Paradis V, Sturm N, de Muret A, Guettier C, Bonsang B, Copie C, Letouzé E, Calderaro J, Imbeaud S, Nault JC, Zucman-Rossi J. | 04/13/2021 |
| Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK). | Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK).
Wang B, Zhang L, Li J, Hua P, Zhang Y. | 01/2/2021 |
| Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. | Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP.
Irie K, Nagai T, Mizuno K., Free PMC Article | 10/24/2020 |
| These results indicate that FRK inhibits human glioma growth via regulating ITGB1/FAK signaling. | FRK suppresses human glioma growth by inhibiting ITGB1/FAK signaling.
Wang J, Cai C, Nie D, Song X, Sun G, Zhi T, Li B, Qi J, Zhang J, Chen H, Shi Q, Yu R. | 06/20/2020 |
| Activated BRK-mediated degradation of SMAD4 is associated with the repression of tumor suppressor gene FRK. | BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.
Miah S, Banks CAS, Ogunbolude Y, Bagu ET, Berg JM, Saraf A, Tettey TT, Hattem G, Dayebgadoh G, Kempf CG, Sardiu M, Napper S, Florens L, Lukong KE, Washburn MP., Free PMC Article | 05/30/2020 |
| TRIM44 promotes cell proliferation by regulating FRK. | TRIM44 promotes cell proliferation and migration by inhibiting FRK in renal cell carcinoma.
Yamada Y, Kimura N, Takayama KI, Sato Y, Suzuki T, Azuma K, Fujimura T, Ikeda K, Kume H, Inoue S., Free PMC Article | 03/14/2020 |
| FRK plays an oncogenic role in lung cancer cells via a novel regulation mechanism of enhancing the stemness of H1299 cells by inducing metabolism reprogramming, which finally promotes epithelial-mesenchymal transition and metastasis | FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming.
Zhang L, Yang Y, Chai L, Bu H, Yang Y, Huang H, Ran J, Zhu Y, Li L, Chen F, Li W. | 02/15/2020 |
| Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma. | Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma.
Hu G, Dasari S, Asmann YW, Greipp PT, Knudson RA, Benson HK, Li Y, Eckloff BW, Jen J, Link BK, Jiang L, Sidhu JS, Wellik LE, Witzig TE, Bennani NN, Cerhan JR, Boddicker RL, Feldman AL., Free PMC Article | 04/18/2019 |
| our results present the first evidence that site-specific promoter methylation contributes to the repression of FRK more so in basal B breast cancers. | Repression of Fyn-related kinase in breast cancer cells is associated with promoter site-specific CpG methylation.
Bagu ET, Miah S, Dai C, Spriggs T, Ogunbolude Y, Beaton E, Sanders M, Goel RK, Bonham K, Lukong KE., Free PMC Article | 09/23/2017 |
| Loss of FRK protein may be implicated into the tumorigenesis and cell motility/invasiveness of human cervical cancer. | Fyn-related kinase expression predicts favorable prognosis in patients with cervical cancer and suppresses malignant progression by regulating migration and invasion.
Zhang X, Li F, Zhu PL. | 02/18/2017 |
| antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. | Antagomir-1290 suppresses CD133⁺ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase.
Sun B, Yang N, Jiang Y, Zhang H, Hou C, Ji C, Liu Y, Zuo P. | 11/21/2015 |
| our results demonstrate a combined mechanism for the anti-proliferative effects of FRK by inhibiting cyclin D1 nucleus accumulation and pRb phosphorylation in glioma cells. | FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation.
Hua L, Zhu M, Song X, Wang J, Fang Z, Zhang C, Shi Q, Zhan W, Wang L, Meng Q, Zhou X, Yu R. | 10/24/2015 |
| FRK over-expression promoted beta-catenin translocation to the plasma membrane, where it formed complex with N-cadherin. | FRK inhibits migration and invasion of human glioma cells by promoting N-cadherin/β-catenin complex formation.
Shi Q, Song X, Wang J, Gu J, Zhang W, Hu J, Zhou X, Yu R. | 09/12/2015 |
| exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors | Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
Pilati C, Letouzé E, Nault JC, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G, Mallet M, Taouji S, Balabaud C, Terris B, Canal F, Paradis V, Scoazec JY, de Muret A, Guettier C, Bioulac-Sage P, Chevet E, Calvo F, Zucman-Rossi J. | 09/20/2014 |
| Data indicaate that the Rak/Frk SH2 and SH3 domains collaborate to increase the Rak-EGFR interaction. | The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor.
Jin L, Craven RJ. | 03/15/2014 |
| The expression levels of FRK were significantly correlated with invasiveness in both Hep3B and HepG2 tumor cell lines. | In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma.
Chen JS, Hung WS, Chan HH, Tsai SJ, Sun HS. | 08/31/2013 |
| these results clearly indicate that FRK may play a protective role against the progression of glioma by suppressing cell migration and invasion | FRK controls migration and invasion of human glioma cells by regulating JNK/c-Jun signaling.
Zhou X, Hua L, Zhang W, Zhu M, Shi Q, Li F, Zhang L, Song C, Yu R. | 04/27/2013 |
| Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. | Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Yu Y, Bhangale TR, Fagerness J, Ripke S, Thorleifsson G, Tan PL, Souied EH, Richardson AJ, Merriam JE, Buitendijk GH, Reynolds R, Raychaudhuri S, Chin KA, Sobrin L, Evangelou E, Lee PH, Lee AY, Leveziel N, Zack DJ, Campochiaro B, Campochiaro P, Smith RT, Barile GR, Guymer RH, Hogg R, Chakravarthy U, Robman LD, Gustafsson O, Sigurdsson H, Ortmann W, Behrens TW, Stefansson K, Uitterlinden AG, van Duijn CM, Vingerling JR, Klaver CC, Allikmets R, Brantley MA Jr, Baird PN, Katsanis N, Thorsteinsdottir U, Ioannidis JP, Daly MJ, Graham RR, Seddon JM., Free PMC Article | 01/21/2012 |
| Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs. | Mutation analysis of the FRK gene in non-small cell lung cancers.
Jin G, Jeon HS, Yang E, Park JY. | 04/2/2011 |
| Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms. | Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.
Ohnuma T, Shibata N, Matsubara Y, Sato S, Yamashina M, Arai H. | 03/13/2008 |
| Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference. | No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
Watanabe T, Ohnuma T, Shibata N, Ohtsuka M, Ueki A, Nagao M, Arai H. | 01/21/2010 |