| These data support the hypothesis that reduced renal Gstm1 plays a role in the development of hypertension. | Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat.
Olson E, Pravenec M, Landa V, Koh-Tan HHC, Dominiczak AF, McBride MW, Graham D. | 06/20/2020 |
| GST-facilitated S-glutathionylation of AMPK may be involved in rapid, full activation of the kinase under mildly oxidative physiological conditions. | Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro.
Klaus A, Zorman S, Berthier A, Polge C, Ramirez S, Michelland S, Sève M, Vertommen D, Rider M, Lentze N, Auerbach D, Schlattner U., Free PMC Article | 02/22/2014 |
| GSTM1 and glutathione S-transferase theta;1 (GSTT1) null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke. | Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk.
Türkanoğlu A, Can Demirdöğen B, Demirkaya S, Bek S, Adali O. | 10/1/2011 |
| This protein has been found differentially expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. | Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
Castro-Dias E, Vieira AS, Werneck CC, Langone F, Novello JC, Martins-de-Souza D. | 04/21/2010 |
| the mu loop is not essential for GST M1 to maintain its structure nor is it required for the enzyme to retain some catalytic activity. However, it is an important determinant of the enzyme's affinity for its substrates. | Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1.
Hearne JL, Colman RF., Free PMC Article | 01/21/2010 |
| These results indicate that rats that are polymorphic for the GST M1 gene exhibit different susceptibilities to CF in vivo. | Different susceptibility to peroxisome proliferator-induced hepatocarcinogenesis in rats with polymorphic glutathione transferase genes.
Kudo T, Asano J, Shimizu T, Nanashima N, Fan Y, Akita M, Ookawa K, Hayakari M, Yokoyama Y, Suto K, Tsuchida S., Free PMC Article | 01/21/2010 |
| The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium | Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons.
Wang JF, Shao L, Sun X, Young LT. | 01/21/2010 |
| Data describe the conformational stability of the chimeric homodimers M(12)-(12) and M(21)-(21) constructed from glutathione transferases M1-1 and M2-2. | Impact of domain interchange on conformational stability and equilibrium folding of chimeric class micro glutathione transferases.
Luo JK, Hornby JA, Wallace LA, Chen J, Armstrong RN, Dirr HW., Free PMC Article | 01/21/2010 |
| Simultaneous disruption of both motifs in the F56S/R81A mutant causes complete dissociation of the dimer to a monomeric protein on the basis of gel filtration chromatography and multiple-angle laser light scattering. | Double mutation at the subunit interface of glutathione transferase rGSTM1-1 results in a stable, folded monomer.
Thompson LC, Walters J, Burke J, Parsons JF, Armstrong RN, Dirr HW. | 01/21/2010 |
| circulating testosterone or one of its metabolites regulates expression of Yb(1)-GST in basal cells of the corpus region indicating a differential regulation with respect to expression in the various cell types and regions of the epididymis. | Immunolocalization of the Yb1 subunit of glutathione S-transferase in the adult rat epididymis following orchidectomy and efferent duct ligation.
Andonian S, Hermo L. | 01/21/2010 |
| The enhanced product release rate by Y115F mutant GSTM1-1 enzyme is proposed to derive from a small shift in the equilibrium population of protein conformers that permit egress of the product (1-chloro-2,4-dinitrobenzene) from the active site. | Local protein dynamics and catalysis: detection of segmental motion associated with rate-limiting product release by a glutathione transferase.
Codreanu SG, Ladner JE, Xiao G, Stourman NV, Hachey DL, Gilliland GL, Armstrong RN. | 01/21/2010 |
| Highly significant, 4-fold reduction of glutathione S-transferase mu type 1 mRNA expression in stroke-prone spontaneously hypertension rat. One coding single nucleotide polymorphism (R202H) and multiple single nucleotide polymorphisms in promoter region. | Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress.
McBride MW, Brosnan MJ, Mathers J, McLellan LI, Miller WH, Graham D, Hanlon N, Hamilton CA, Polke JM, Lee WK, Dominiczak AF. | 01/21/2010 |