| Paradoxical electro-olfactogram responses in TMEM16B knock-out mice. | Paradoxical electro-olfactogram responses in TMEM16B knock-out mice.
Guarneri G, Pifferi S, Dibattista M, Reisert J, Menini A., Free PMC Article | 02/28/2023 |
| TMEM16b regulates action potential firing in lateral septum and aggression in male mice. | TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.
Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY., Free PMC Article | 07/4/2020 |
| Ano2/TMEM16B is a Ca2+-activated chloride channel in vagal afferents of nodose neurons and a major determinant of CCK-induced satiety, body weight control, and energy expenditure, making it a potential therapeutic target in obesity. | TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons.
Wang R, Lu Y, Cicha MZ, Singh MV, Benson CJ, Madden CJ, Chapleau MW, Abboud FM., Free PMC Article | 06/6/2020 |
| Here the authors report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety modulation. | TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.
Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY., Free PMC Article | 02/8/2020 |
| Study provides the first in vivo evidence toward an alternative or additional role for Ano2 in the olfactory transduction cascade, where it may serve as a feedback mechanism to clamp olfactory receptor neurons spike output. | Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.
Zak JD, Grimaud J, Li RC, Lin CC, Murthy VN., Free PMC Article | 11/2/2019 |
| Results of behavioral studies obtained from Ano2 (-/-) mice, a mouse line that was previously shown to lack this particular mode of ionic plasticity. The animals display motor coordination deficits that constitute a condition of mild ataxia. Moreover, motor learning is severely impaired in Ano2 (-/-) mice, suggesting cerebellar dysfunction. | Impaired Motor Coordination and Learning in Mice Lacking Anoctamin 2 Calcium-Gated Chloride Channels.
Neureither F, Ziegler K, Pitzer C, Frings S, Möhrlen F., Free PMC Article | 08/4/2018 |
| Results suggest that the anoctamin 2-mediated amplification mechanism enables mice to track weak, unfamiliar olfactory cues. | Tracking of unfamiliar odors is facilitated by signal amplification through anoctamin 2 chloride channels in mouse olfactory receptor neurons.
Neureither F, Stowasser N, Frings S, Möhrlen F., Free PMC Article | 05/5/2018 |
| TMEM16B controls AP firing and ensures correct glomerular targeting of olfactory sensory neurons s expressing I7. | The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons.
Pietra G, Dibattista M, Menini A, Reisert J, Boccaccio A., Free PMC Article | 11/26/2017 |
| Loss of TMEM16B expression resulted in the absence of Calcium-activated Chloride channels in inferior Olive neurons, leading to markedly diminished action potential firing of IO neurons. TMEM16B knockout mice. Moreover, exhibited severe cerebellar motor learning deficits. | Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.
Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H., Free PMC Article | 09/30/2017 |
| The siRNA knock-down suggests that Ano2 contributes to Ca(2+)-dependent chloride conductance in the RPE. | Anoctamin2 (TMEM16B) forms the Ca(2+)-activated Cl(-) channel in the retinal pigment epithelium.
Keckeis S, Reichhart N, Roubeix C, Strauß O. | 06/24/2017 |
| Data indicate that anoctamin channel proteins ANO1 and ANO2 are expressed in the cerebellum. | Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
Zhang W, Schmelzeisen S, Parthier D, Frings S, Möhrlen F., Free PMC Article | 06/28/2016 |
| Ano6 and Ano2 proteins co-localize in the ciliary membrane microdomains.Thus, we provide evidence for interaction of ANO2 and ANO6 in olfactory cilia. | Co-expression of anoctamins in cilia of olfactory sensory neurons.
Henkel B, Drose DR, Ackels T, Oberland S, Spehr M, Neuhaus EM. | 10/3/2015 |
| Selective antagonism of ANO2 promotes relaxation of spontaneous myometrial contractions. It inhibits both agonist-induced and spontaneous transient inward currents and abolishes G-protein coupled receptor mediated elevations in intracellular calcium. | Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility.
Bernstein K, Vink JY, Fu XW, Wakita H, Danielsson J, Wapner R, Gallos G., Free PMC Article | 01/31/2015 |
| Data suggest different functional roles for TMEM16A and TMEM16B in the developing as well as in the postnatal olfactory epithelium | Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium.
Maurya DK, Menini A. | 01/17/2015 |
| Our results provide the first evidence that TMEM16B gating is modulated by permeant anions and provide the basis for future studies aimed at identifying the molecular determinants of TMEM16B ion selectivity and gating. | Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel.
Betto G, Cherian OL, Pifferi S, Cenedese V, Boccaccio A, Menini A., Free PMC Article | 11/22/2014 |
| The putative pore-loop of TMEM16A and TMEM16B channels affects channel density in cell membranes. | Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes.
Adomaviciene A, Smith KJ, Garnett H, Tammaro P., Free PMC Article | 02/8/2014 |
| the main functional features of ANO 1 and ANO 2 chloride channels in the nose and suggest their significance for nasal physiology. | Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.
Dauner K, Lissmann J, Jeridi S, Frings S, Möhrlen F. | 10/20/2012 |
| TMEM16B calcium-activated chloride channels control action potential waveform and synaptic efficacy in hippocampal neurons. | Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.
Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, Jan LY., Free PMC Article | 06/23/2012 |
| Data show that Ano2 is expressed in the main olfactory epithelium and in the vomeronasal organ, which also expresses the related Ano1 channel. | Ca2+-activated Cl− currents are dispensable for olfaction.
Billig GM, Pál B, Fidzinski P, Jentsch TJ. | 08/20/2011 |
| TMEM16b/anoctamin2 is likely to be a major subunit of the native olfactory Ca(2+)-activated Cl(-) current. | Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.
Sagheddu C, Boccaccio A, Dibattista M, Montani G, Tirindelli R, Menini A., Free PMC Article | 03/12/2011 |
| Tmem16b expression is highly specific for the OE, in contrast to the closely related Tmem16a, which shows a broad expression pattern in secretory epithelial cells. | Tmem16b is specifically expressed in the cilia of olfactory sensory neurons.
Rasche S, Toetter B, Adler J, Tschapek A, Doerner JF, Kurtenbach S, Hatt H, Meyer H, Warscheid B, Neuhaus EM. | 04/19/2010 |
| Our results demonstrate that mTMEM16B functions as a Ca(2+)-activated Cl(-) channel when expressed in HEK 293T cells. | TMEM16B induces chloride currents activated by calcium in mammalian cells.
Pifferi S, Dibattista M, Menini A. | 01/21/2010 |
| ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. | ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification.
Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H, Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H., Free PMC Articles: PMC2702256, PMC2702256 | 01/21/2010 |
| Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell. | ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification.
Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H, Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H., Free PMC Articles: PMC2702256, PMC2702256 | 07/27/2009 |
| TMEM16B is lost from photoreceptor membranes of MPP4-deficient mice | TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
Stöhr H, Heisig JB, Benz PM, Schöberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL., Free PMC Article | 01/21/2010 |