| The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2. | The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2.
Gu M, Li X, Wu R, Cheng X, Zhou S, Gu X., Free PMC Article | 02/15/2024 |
| The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression. | The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression.
Guo X, Zhang BF, Zhang J, Liu G, Hu Q, Chen J., Free PMC Article | 05/7/2022 |
| Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat. | Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.
Feng W, Guan Z, Xing D, Li X, Ying WZ, Remedies CE, Inscho EW, Sanders PW., Free PMC Article | 07/10/2021 |
| Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor. | Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor.
Surles-Zeigler MC, Li Y, Distel TJ, Omotayo H, Ge S, Ford BD., Free PMC Article | 12/1/2018 |
| data indicate a role for ETS-1 in the control of the GAL2R gene expression. | Characterization of the Rat GAL2R Promoter: Positive Role of ETS-1 in Regulation of the Rat GAL2R Gene in PC12 Cells.
Yang Y, Liu L, Luo H, Li Y, Li H, Xu ZD. | 05/12/2018 |
| Reduced renal expression of ETS-1 prevented hypertension-associated kidney injury in SS rats | Haploinsufficiency of the Transcription Factor Ets-1 Is Renoprotective in Dahl Salt-Sensitive Rats.
Feng W, Chen B, Xing D, Li X, Fatima H, Jaimes EA, Sanders PW., Free PMC Article | 11/11/2017 |
| miR-125a-5p directly targets ETS-1, a transcription factor implicated in cell proliferation and migration and is crucial in PDGF-BB pathway in vascular smooth muscle cells. | miR-125a-5p Modulates Phenotypic Switch of Vascular Smooth Muscle Cells by Targeting ETS-1.
Gareri C, Iaconetti C, Sorrentino S, Covello C, De Rosa S, Indolfi C. | 07/15/2017 |
| Knockdown of Ets-1 by siRNA significantly inhibited the inductive effects of Ang II on cell proliferation and expression of CTGF and PAI-1 | Ets-1 upregulation mediates angiotensin II-related cardiac fibrosis.
Hao G, Han Z, Meng Z, Wei J, Gao D, Zhang H, Wang N., Free PMC Article | 10/8/2016 |
| Knockdown of miR-208b-3p expression attenuated apoptosis, while knockdown of Ets1 promoted apoptosis in myocardial ischemia reperfused rats. | Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p.
Bian C, Xu T, Zhu H, Pan D, Liu Y, Luo Y, Wu P, Li D., Free PMC Article | 07/2/2016 |
| that salt-sensitive hypertension results in increased glomerular expression of phosphorylated ETS-1 and suggested that ETS-1 plays an important role in the pathogenesis of end-organ injury in salt-sensitive hypertension. | Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension.
Feng W, Chumley P, Prieto MC, Miyada K, Seth DM, Fatima H, Hua P, Rezonzew G, Sanders PW, Jaimes EA., Free PMC Article | 05/16/2015 |
| ETS-1 overexpression induces beta-cell dysfunction partly through up-regulation of COX-2 gene expression. | Transcription factor Ets-1 inhibits glucose-stimulated insulin secretion of pancreatic β-cells partly through up-regulation of COX-2 gene expression.
Zhang XF, Zhu Y, Liang WB, Zhang JJ. | 04/4/2015 |
| These data indicate that Ets-1 may influence neuronal injury following ischemia. | Computational identification of conserved transcription factor binding sites upstream of genes induced in rat brain by transient focal ischemic stroke.
Pulliam JV, Xu Z, Ford GD, Liu C, Li Y, Stovall KC, Cannon VS, Tewolde T, Moreno CS, Ford BD., Free PMC Article | 07/27/2013 |
| Decreased expression of Ets-1 and increased expression of TIMP-2 may play an important role in the development of glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy | Renal expression of proto-oncogene Ets-1 on matrix remodeling in experimental diabetic nephropathy.
Liu DX, Liu XM, Su Y, Zhang XJ. | 08/13/2011 |
| Ets-1 may participate and play an important role in the regulation of follicular development, corpus luteum formation, maintenance, and regression in estrus and pregnancy in rats. | Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.
Xiao X, Liu A, Wen H, Tian Y, Ni J, Liu G. | 01/21/2010 |
| Ets transcription factors play important roles for basic properties of rat C6 glioma cells, and targeting of these factors may become a useful tool for therapeutic strategies against malignant gliomas. | Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes.
Sahin A, Vercamer C, Kaminski A, Fuchs T, Florin A, Hahne JC, Mattot V, Pourtier-Manzanedo A, Pietsch T, Fafeur V, Wernert N. | 01/21/2010 |
| Ang II-induced osteopontin expression in vascular smooth muscle cells is mediated by signaling cascades involving G(q/11) the Ras-ERK axis, and the Src kinase family, and by the transcription factor, Ets-1. | Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1.
Abe K, Nakashima H, Ishida M, Miho N, Sawano M, Soe NN, Kurabayashi M, Chayama K, Yoshizumi M, Ishida T. | 01/21/2010 |
| Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells. | Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells.
Milkiewicz M, Uchida C, Gee E, Fudalewski T, Haas TL., Free PMC Article | 01/21/2010 |
| Ets family members Ets-1 and Elk-1 can positively regulate COX-2 promoter activity. | Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells.
Zhang X, Zhang J, Yang X, Han X. | 01/21/2010 |
| VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy. | Coordinated expression of Ets-1, pERK1/2, and VEGF in retina of streptozotocin-induced diabetic rats.
Du ZJ, Kamei M, Suzuki M, Tano Y, Wang BR, Hui YN. | 01/21/2010 |
| diabetes may contribute to increased cell proliferation due to N-ras constitutive activation, as well as to enhanced invasion and metastatic potential by increasing ets-1 levels | Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential.
Vairaktaris E, Goutzanis L, Kalokerinos G, Yannopoulos A, Yapijakis C, Vassiliou S, Spyridonidou S, Vylliotis A, Nkenke E, Lazaris AC, Tesseromatis C, Patsouris E. | 01/21/2010 |
| Despite lacking an obvious motif for a canonical D-site sequence, recognized by ERK2 and used to promote catalysis, transcription factor Ets-1 is efficiently phosphorylated by ERK2 and is shown to interact with it. | Expanding the repertoire of an ERK2 recruitment site: cysteine footprinting identifies the D-recruitment site as a mediator of Ets-1 binding.
Abramczyk O, Rainey MA, Barnes R, Martin L, Dalby KN., Free PMC Article | 01/21/2010 |
| Ets-1 has a role in regulation of p21WAF1/Cip1 | Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter.
Zhang C, Kavurma MM, Lai A, Khachigian LM. | 01/21/2010 |
| Sp1, like Ets-1, induces PDGF-D transcription and mRNA expression; H2O2 stimulates Ets-1, but not Sp1, and activates D3-dependent PDGF-D transcription | Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1.
Liu MY, Eyries M, Zhang C, Santiago FS, Khachigian LM. | 01/21/2010 |
| Ets-1 promotes degradation of extracellular matrix proteins and is critical for integral kidney glomerular reorganization | Transcription factor Ets-1 is essential for mesangial matrix remodeling.
Mizui M, Isaka Y, Takabatake Y, Sato Y, Kawachi H, Shimizu F, Takahara S, Ito T, Imai E. | 01/21/2010 |
| The colocalization of Ets-1 and HIF-1alpha in hypoxic areas suggests that hypoxia may induce Ets-1 and HIF-1alpha expression during joint inflammation | The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis.
Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE, Winrow VR. | 01/21/2010 |