| Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration. | Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration.
Zheng SK, Zhao XK, Wu H, He DW, Xiong L, Cheng XG., Free PMC Article | 07/30/2024 |
| ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes. | ATF3/EGR1 regulates myocardial ischemia/reperfusion injury induced autophagy and inflammation in cardiomyocytes.
Li L, Fu G, Liu C, Liu Y. | 04/29/2024 |
| PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic. | PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbα gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic.
Yakmaz F, Bozkurt AS, Görücü Yilmaz Ş. | 03/12/2024 |
| The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation. | The involvement of EGR1 in neuron apoptosis in the in vitro model of spinal cord injury via BTG2 up-regulation.
Wu F, Zhang P, Zhou G. | 06/2/2023 |
| Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo. | Acidosis-Induced Regulation of Egr1 and Ccn1 In Vitro and in Experimental Tumours In Vivo.
Rauschner M, Reime S, Riemann A, Thews O. | 01/11/2023 |
| Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model. | Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model.
Iwakura Y, Kawahara-Miki R, Kida S, Sotoyama H, Gabdulkhaev R, Takahashi H, Kunii Y, Hino M, Nagaoka A, Izumi R, Shishido R, Someya T, Yabe H, Kakita A, Nawa H. | 09/24/2022 |
| Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage via STAT3/NF-kappaB Pathway by Reducing RXRalpha Acetylation Level. | Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage via STAT3/NF-κB Pathway by Reducing RXRα Acetylation Level.
Xie L, Wang Y, Chen Z. | 04/23/2022 |
| Temporal changes in Egr-1 and c-fos expression in rat models of myocardial ischemia. | Temporal changes in Egr-1 and c-fos expression in rat models of myocardial ischemia.
Zhai LQ, Guo XJ, Li Z, Sun RF, Jin QQ, Liu MZ, Guo HL, Gao CR. | 08/21/2021 |
| miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia. | miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia.
Su B, Wang X, Sun Y, Long M, Zheng J, Wu W, Li L., Free PMC Article | 05/29/2021 |
| Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain. | Ca(v)3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain.
Tomita S, Sekiguchi F, Kasanami Y, Naoe K, Tsubota M, Wake H, Nishibori M, Kawabata A. | 05/22/2021 |
| Effects of Egr1 on pancreatic acinar intracellular trypsinogen activation and the associated ceRNA network. | Effects of Egr1 on pancreatic acinar intracellular trypsinogen activation and the associated ceRNA network.
Gao B, Zhang X, Xue D, Zhang W., Free PMC Article | 05/1/2021 |
| Association of medial corticostriatal regions with amphetamine-induced emission of 50kHz vocalizations as studied by Zif-268 expression in the rat brain. | Association of medial corticostriatal regions with amphetamine-induced emission of 50 kHz vocalizations as studied by Zif-268 expression in the rat brain.
Mulvihill KG, Brudzynski SM. | 04/3/2021 |
| Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor. | Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor.
Kosmowska B, Ossowska K, Wardas J., Free PMC Article | 04/3/2021 |
| Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation. | Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation.
Trask S, Dulka BN, Helmstetter FJ., Free PMC Article | 02/20/2021 |
| Recognition memory reconsolidation requires hippocampal Zif268. | Recognition memory reconsolidation requires hippocampal Zif268.
Gonzalez MC, Rossato JI, Radiske A, Pádua Reis M, Cammarota M., Free PMC Article | 11/21/2020 |
| Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy. | Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.
Qian ZY, Jiang F, Tang J, Ge DW, Chen HT, Zheng SN, Cao XJ, Ge YB, Yang L. | 10/10/2020 |
| Down-regulation of Egr1 partially reduced the injurious effects of hyperglycaemia on retinal vascular function via inhibiting p53 expression. | Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription.
Ao H, Liu B, Li H, Lu L., Free PMC Article | 07/18/2020 |
| Upregulated miR-124 inhibited the expression of EGR1, by which mechanism miR-124 reduced the neurological deficits induced by isoflurane in neonatal rats through inhibiting apoptosis of hippocampal neurons. | microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1.
Yang W, Guo Q, Li J, Wang X, Pan B, Wang Y, Wu L, Yan J, Cheng Z. | 06/13/2020 |
| Study on kidney tissue of LETO rats and human HK-2 cell line cultured in the high-glucose medium found that expression of miR-192 was decreased, whereas the expression of Egr1 was increased. miR-192 can act on Egr1 through 3'-UTR to reduce its expression and causing degradation of TGF-beta1 and fibronectin preventing progression of tubulointerstitial fibrosis and diabetic nephropathy. | miR-192 prevents renal tubulointerstitial fibrosis in diabetic nephropathy by targeting Egr1.
Liu F, Zhang ZP, Xin GD, Guo LH, Jiang Q, Wang ZX. | 12/14/2019 |
| Together, these results illustrate a clear maturation of Egr-1 expression that is both age- and experience-dependent. In addition, the data suggest that regional activity and plasticity within the medial prefrontal cortex on the preexposure but not the training day may contribute to the ontogenetic profile of the effect. | Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).
Robinson-Drummer PA, Chakraborty T, Heroux NA, Rosen JB, Stanton ME., Free PMC Article | 09/21/2019 |
| The results of this study suggest that IEGs and BDNF in these brain regions may play key roles in mediating the negative motivational component of opiate withdrawal. | Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids.
García-Pérez D, Ferenczi S, Kovács KJ, Milanés MV. | 05/4/2019 |
| Zif268 knockdown reduced response memory expression 72H, but not 7d later. Western blotting revealed a non-significant increase in Zif268 in the posterior dorsolateral striatum in rats using response memories, but there was no change in Zif268 expression in the hippocampus following retrieval of a place memory. | Knockdown of zif268 in the Posterior Dorsolateral Striatum Does Not Enduringly Disrupt a Response Memory of a Rewarded T-Maze Task.
Cahill EN, Vousden GH, Exton-McGuinness MTJ, Beh IRC, Swerner CB, Macak M, Abas S, Cole CC, Kelleher BF, Everitt BJ, Milton AL., Free PMC Article | 02/23/2019 |
| Deep Brain Stimulation mitigated fear, partially improved anxiety-like behavior, reversed neurocircuitry abnormalities, and reduced BasoLateral Amygdala cell firing in a preclinical model of PTSD. | Prefrontal Cortex Deep Brain Stimulation Improves Fear and Anxiety-Like Behavior and Reduces Basolateral Amygdala Activity in a Preclinical Model of Posttraumatic Stress Disorder.
Reznikov R, Bambico FR, Diwan M, Raymond RJ, Nashed MG, Nobrega JN, Hamani C., Free PMC Article | 02/9/2019 |
| The results proved Egr-1 mediated regulation of miR-99 family. | Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy.
Ramasamy S, Velmurugan G, Rekha B, Anusha S, Shanmugha Rajan K, Shanmugarajan S, Ramprasath T, Gopal P, Tomar D, Karthik KV, Verma SK, Garikipati VNS, Sudarsan R. | 01/5/2019 |
| Study found an association between contextual fear conditioning deficits in alcohol-exposed animals with a decrease in Egr-1 mRNA expression in the infralimbic and prelimbic subregions of the medial frontal cortex (mPFC); conclude that memory processes in mPFC associated with the context-shock association phase are the most susceptible to the teratogenic effects of neonatal alcohol. | Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.
Jablonski SA, Robinson-Drummer PA, Schreiber WB, Asok A, Rosen JB, Stanton ME., Free PMC Article | 12/22/2018 |