| AZIN2 is associated with apoptosis of germ cells in undescended testis. | AZIN2 is associated with apoptosis of germ cells in undescended testis.
Gao Y, Xu S, Qiao J, Wang C, Wang K, Sun J, Liu L, Li L, Liang M, Hu K. | 08/26/2024 |
| Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity. | Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity.
Lambertos A, Nuñez-Sanchez MA, López-García C, López-Contreras AJ, Ramos-Molina B, Peñafiel R., Free PMC Article | 02/4/2023 |
| Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. | Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC., Free PMC Article | 09/25/2021 |
| Testis of mice with different alterations in spermatogenesis and fertility, induced either genetically or pharmacologically, showed that both AZIN2 and OAZ3 are mainly expressed in the haploid germinal cells. AZIN2 was detected in spermatids and spermatozoa, as well as in Leydig cells, and in epithelial epidydimal cells. | New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility.
Lambertos A, Ramos-Molina B, López-Contreras AJ, Cremades A, Peñafiel R., Free PMC Article | 05/25/2019 |
| show, for the first time, an element of polyamine metabolism -AZIN2-, so far described as exclusively devoted to the control of polyamine concentrations, involved in regulating the biosynthesis and content of other amines like serotonin and histamine. | A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells.
Acosta-Andrade C, Lambertos A, Urdiales JL, Sánchez-Jiménez F, Peñafiel R, Fajardo I. | 12/9/2017 |
| in contrast to human ODCp, mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity | Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.
López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R. | 09/17/2014 |
| AZIN2 may have a role in the modulation of reproductory and secretory functions. | Antizyme inhibitor 2 hypomorphic mice. New patterns of expression in pancreas and adrenal glands suggest a role in secretory processes.
López-Garcia C, Ramos-Molina B, Lambertos A, López-Contreras AJ, Cremades A, Peñafiel R., Free PMC Article | 02/22/2014 |
| expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural stem cells | Retroviral expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural stem cells.
Bokara KK, Kwon KH, Nho Y, Lee WT, Park KA, Lee JE. | 09/3/2011 |
| Both endogenous and FLAG-tagged AZIN2 localize to post-Golgi vesicles of the secretory pathway. Immuno-electron microscopy revealed that the vesicles associate mainly with the trans-Golgi network. | Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking.
Kanerva K, Mäkitie LT, Bäck N, Andersson LC. | 06/28/2010 |
| AZIN2 expression appears to be restricted to brain and testis and it is a labile protein degraded by a ubiquitin-dependent mechanism. | Antizyme inhibitor 2: molecular, cellular and physiological aspects.
López-Contreras AJ, Ramos-Molina B, Cremades A, Peñafiel R. | 06/14/2010 |
| granule subtype-specific expression and its induction after MC activation suggest a role for AZIN2 as a local, in situ regulator of polyamine biosynthesis in association with serotonin-containing granules of mast cells | Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion.
Kanerva K, Lappalainen J, Mäkitie LT, Virolainen S, Kovanen PT, Andersson LC., Free PMC Article | 01/25/2010 |
| differences in the subcellular distribution of AZIN1 and AZIN2 | Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes.
López-Contreras AJ, Sánchez-Laorden BL, Ramos-Molina B, de la Morena ME, Cremades A, Peñafiel R. | 01/21/2010 |
| AZIN2 affects polyamine homeostasis not only by increasing ornithine decarboxylase activity but also by stimulating polyamine uptake, through negating the inhibitory effect of the antizymes | Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells.
López-Contreras AJ, Ramos-Molina B, Cremades A, Peñafiel R., Free PMC Article | 01/21/2010 |