| GluN3A and Excitatory Glycine Receptors in the Adult Hippocampus. | GluN3A and Excitatory Glycine Receptors in the Adult Hippocampus.
Hurley EP, Mukherjee B, Fang LZ, Barnes JR, Barron JC, Nafar F, Hirasawa M, Parsons MP., | 10/25/2024 |
| Dysfunction of GluN3A subunit is involved in depression-like behaviors through synaptic deficits. | Dysfunction of GluN3A subunit is involved in depression-like behaviors through synaptic deficits.
Zhang M, Kong X, Chen J, Liu W, Liu C, Dou X, Jiang L, Luo Y, Song M, Miao P, Tang Y, Xiu Y. | 08/25/2023 |
| GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. | GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits.
Bossi S, Dhanasobhon D, Ellis-Davies GCR, Frontera J, de Brito Van Velze M, Lourenço J, Murillo A, Luján R, Casado M, Perez-Otaño I, Bacci A, Popa D, Paoletti P, Rebola N., Free PMC Article | 08/13/2022 |
| Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A. | Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.
Zhong W, Wu A, Berglund K, Gu X, Jiang MQ, Talati J, Zhao J, Wei L, Yu SP., Free PMC Article | 05/7/2022 |
| A new insight into mechanisms of interferon alpha neurotoxicity: Expression of GRIN3A subunit of NMDA receptors and NMDA-evoked exocytosis. | A new insight into mechanisms of interferon alpha neurotoxicity: Expression of GRIN3A subunit of NMDA receptors and NMDA-evoked exocytosis.
Obolenskaya M, Dotsenko V, Martsenyuk O, Ralchenko S, Krupko O, Pastukhov A, Filimonova N, Starosila D, Chernykh S, Borisova T. | 02/12/2022 |
| Temporal Dynamics and Neuronal Specificity of Grin3a Expression in the Mouse Forebrain. | Temporal Dynamics and Neuronal Specificity of Grin3a Expression in the Mouse Forebrain.
Murillo A, Navarro AI, Puelles E, Zhang Y, Petros TJ, Pérez-Otaño I., Free PMC Article | 01/29/2022 |
| study found GluN1/GluN3A receptors are operational in neurons of the medial habenula (MHb), an epithalamic area controlling aversive physiological states; in the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors; reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning | Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.
Otsu Y, Darcq E, Pietrajtis K, Mátyás F, Schwartz E, Bessaih T, Abi Gerges S, Rousseau CV, Grand T, Dieudonné S, Paoletti P, Acsády L, Agulhon C, Kieffer BL, Diana MA., Free PMC Article | 05/2/2020 |
| Thsese findings confirm the existence of presynaptic GluN3A-containing release-regulating NMDARs in mouse hippocampal glutamatergic nerve endings. | Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases.
Olivero G, Vergassola M, Cisani F, Usai C, Pittaluga A. | 01/11/2020 |
| In the prefrontal cortex of GluN3A knock-out mice, the expression of the oxytocin receptor was significantly lower. | Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit.
Lee JH, Zhang JY, Wei ZZ, Yu SP., Free PMC Article | 01/12/2019 |
| This study for the first time provides insights into transcriptome changes upon the specific knockdown of an NMDAR subunit in NSCs, which may help to identify additional functions and downstream pathways of GluN3A and GluN3A-containing NMDARs | The siRNA-mediated knockdown of GluN3A in 46C-derived neural stem cells affects mRNA expression levels of neural genes, including known iGluR interactors.
Pachernegg S, Eilebrecht S, Eilebrecht E, Schöneborn H, Neumann S, Benecke AG, Hollmann M., Free PMC Article | 04/7/2018 |
| results implicate GluN3A reactivation in a broad spectrum of early-stage synaptic transmission deficits in YAC128 mice | GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models.
Mahfooz K, Marco S, Martínez-Turrillas R, Raja MK, Pérez-Otaño I, Wesseling JF. | 03/3/2018 |
| Findings suggest that N-methyl-D-aspartate receptor subunit GluN3A, expressed in the adult olfactory system, plays a significant regulatory role in olfactory development and functional activity. | Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse.
Lee JH, Wei L, Deveau TC, Gu X, Yu SP. | 09/30/2017 |
| In GluN3A knock-out mice there was enhanced cell death in ischemic stroke animals. | A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse.
Lee JH, Wei ZZ, Chen D, Gu X, Wei L, Yu SP., Free PMC Article | 06/20/2015 |
| find that visual experience modifies preNMDAR(GluN3A) mediated plasticity specifically at visual cortex L4-L2/3 synapses. | Synapse-specific control of experience-dependent plasticity by presynaptic NMDA receptors.
Larsen RS, Smith IT, Miriyala J, Han JE, Corlew RJ, Smith SL, Philpot BD., Free PMC Article | 12/20/2014 |
| and was dependent on the ability of GluN3A to bind the postsynaptic scaffold GIT1. Together, these data provide strong evidence that GluN3A prevents the activity-dependent stabilization of synapses thereby promoting spine pruning. | GluN3A promotes dendritic spine pruning and destabilization during postnatal development.
Kehoe LA, Bellone C, De Roo M, Zandueta A, Dey PN, Pérez-Otaño I, Muller D., Free PMC Article | 09/13/2014 |
| This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies--{REVIEW} | GluN3A: an NMDA receptor subunit with exquisite properties and functions.
Kehoe LA, Bernardinelli Y, Muller D., Free PMC Article | 07/26/2014 |
| These findings reveal an early pathogenic role of GluN3A dysregulation in Huntington's disease. | Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I., Free PMC Article | 11/2/2013 |
| A potential novel role is revealed for the NMDAR subunit GluN3A in locomotion, pain sensation and learning/memory in adult animals. | Regulatory roles of the NMDA receptor GluN3A subunit in locomotion, pain perception and cognitive functions in adult mice.
Mohamad O, Song M, Wei L, Yu SP., Free PMC Article | 06/15/2013 |
| Constitutive deletion of NR3A, a modulatory subunit of oligodendroglial NMDARs, does not alter the course of oligodendrocyte glycoprotein peptide 35-55 (MOG-peptide) experimental autoimmune encephalomyelitis. | Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development.
Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D., Free PMC Article | 03/10/2012 |
| Data indicate that NR3A relieves preNMDARs from the dual-activation requirement of ligand-binding and depolarization; the developmental removal of NR3A limits preNMDAR functionality by restoring this associative property. | NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity.
Larsen RS, Corlew RJ, Henson MA, Roberts AC, Mishina M, Watanabe M, Lipton SA, Nakanishi N, Pérez-Otaño I, Weinberg RJ, Philpot BD., Free PMC Article | 04/16/2011 |
| Data indicate that NR3A plays a significant role in the development of excitatory synapses in layer V of the developing neocortex. | Altered development of glutamatergic synapses in layer V pyramidal neurons in NR3A knockout mice.
Zhou C, Jensen FE, Sucher NJ., Free PMC Article | 04/12/2010 |
| This study suggested that NR3A behaves as a molecular brake to prevent the premature strengthening and stabilization of excitatory synapses. | Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation.
Roberts AC, Díez-García J, Rodriguiz RM, López IP, Luján R, Martínez-Turrillas R, Picó E, Henson MA, Bernardo DR, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, Wetsel WC, Philpot BD, Pérez-Otaño I., Free PMC Article | 01/21/2010 |
| Zn(2+) acts as a potent positive modulator and agonist at the NR1 subunit of NR1/NR3A receptors | Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.
Madry C, Betz H, Geiger JR, Laube B., Free PMC Article | 01/21/2010 |
| Taken together, these results show that NR3A subunits contribute to NMDAR responses from both synaptic and extrasynaptic receptors, likely composed of NR1, NR2, and NR3 subunits. | Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons.
Tong G, Takahashi H, Tu S, Shin Y, Talantova M, Zago W, Xia P, Nie Z, Goetz T, Zhang D, Lipton SA, Nakanishi N., Free PMC Article | 01/21/2010 |
| decrease in NMDA-receptor activity in alpha-neurexin-deficient synapses | Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.
Kattenstroth G, Tantalaki E, Südhof TC, Gottmann K, Missler M., Free PMC Article | 01/21/2010 |