| Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. | Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice.
Altés G, Olomí A, Perramon-Güell A, Hernández S, Casanovas A, Pérez A, Díaz-Tocados JM, Valdivielso JM, Megino C, Navaridas R, Matias-Guiu X, Klein OD, Egea J, Dolcet X, Yeramian A, Encinas M., Free PMC Article | 10/3/2024 |
| Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development. | Loss of SPRY2 contributes to cancer-associated fibroblasts activation and promotes breast cancer development.
Dai H, Xu W, Wang L, Li X, Sheng X, Zhu L, Li Y, Dong X, Zhou W, Han C, Mao Y, Yao L., Free PMC Article | 09/8/2023 |
| Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13. | Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13.
Schumacher MA, Liu CY, Katada K, Thai MH, Hsieh JJ, Hansten BJ, Waddell A, Rosen MJ, Frey MR., Free PMC Article | 03/24/2023 |
| Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling. | Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.
Hruba E, Kavkova M, Dalecka L, Macholan M, Zikmund T, Varecha M, Bosakova M, Kaiser J, Krejci P, Hovorakova M, Buchtova M. | 01/1/2022 |
| Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. | Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Sripada A, Sirohi K, Michalec L, Guo L, McKay JT, Yadav S, Verma M, Good J, Rollins D, Gorska MM, Alam R., Free PMC Article | 07/31/2021 |
| Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3beta-mediated restriction of epithelial IL-33. | Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.
Schumacher MA, Hsieh JJ, Liu CY, Appel KL, Waddell A, Almohazey D, Katada K, Bernard JK, Bucar EB, Gadeock S, Maselli KM, Washington MK, Grikscheit TC, Warburton D, Rosen MJ, Frey MR., Free PMC Article | 02/20/2021 |
| Using the developing long bone as a model organ, the effects of Spry2 deletion on osteogenic cells appear complex in part because of its ubiquitous expression and also due to the multiple cell-specific effects of the encoded protein | Specification of Sprouty2 functions in osteogenesis in in vivo context.
Vesela B, Svandova E, Hovorakova M, Peterkova R, Kratochvilova A, Pasovska M, Ramesova A, Lesot H, Matalova E., Free PMC Article | 05/16/2020 |
| Results suggest that Sprouty2 is involved in the control of osteoblast proliferation and differentiation by downregulating the FGF-ERK1/2 and BMP-Smad pathways, and suppresses the induction of markers of osteoblast differentiation. | Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways.
Taketomi T, Onimura T, Yoshiga D, Muratsu D, Sanui T, Fukuda T, Kusukawa J, Nakamura S. | 11/9/2019 |
| Loss of Spry1/2 enhances the survival of effector CD8+ T cells and results in the formation of more protective memory cells. Deleting Spry1/2 in antigen-specific CD8+ T cells may have therapeutic potential for enhancing the survival and functionality of effector and memory CD8+ T cells in vivo. | Lack of Sprouty 1 and 2 enhances survival of effector CD8(+) T cells and yields more protective memory cells.
Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S., Free PMC Article | 10/13/2018 |
| These results identify Spry2 as a critical regulator of endochondral bone formation that modulates signaling in both osteoblast and chondrocyte lineages. | Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.
Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD., Free PMC Article | 12/23/2017 |
| MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. | Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.
Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, Dumon S, García P, Frampton J., Free PMC Article | 10/14/2017 |
| Spry2 is a novel unfolded protein response target and its upregulation is dependent on PERK. Knockdown of Spry2 resulted in reduced expression of Serca2, reduced endoplasmic reticulum calcium levels, and induction of the UPR. Spry2 deletion in the adult mouse beta-cell caused hyperglycemia and hypoinsulinemia. | A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.
Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM., Free PMC Article | 08/26/2017 |
| these results establish SPRY2 as a critical negative regulator of BCR-mediated MAPK-Erk signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia. | Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL.
Shukla A, Rai K, Shukla V, Chaturvedi NK, Bociek RG, Pirruccello SJ, Band H, Lu R, Joshi SS., Free PMC Article | 06/24/2017 |
| In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK signaling. | Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Thongrong S, Hausott B, Marvaldi L, Agostinho AS, Zangrandi L, Burtscher J, Fogli B, Schwarzer C, Klimaschewski L., Free PMC Article | 01/14/2017 |
| Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF and EGF stimulation, whereas it diminished proliferation of gingival epithelial cells. | Mutation of Spry2 induces proliferation and differentiation of osteoblasts but inhibits proliferation of gingival epithelial cells.
Sanui T, Tanaka U, Fukuda T, Toyoda K, Taketomi T, Atomura R, Yamamichi K, Nishimura F. | 03/26/2016 |
| Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer | Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer: a working hypothesis.
Assinder SJ, Beniamen D, Lovicu FJ., Free PMC Article | 03/5/2016 |
| in embryos with lower Spry2;Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud | Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.
Lochovska K, Peterkova R, Pavlikova Z, Hovorakova M., Free PMC Article | 01/30/2016 |
| The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice | Enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice.
Marvaldi L, Thongrong S, Kozłowska A, Irschick R, Pritz CO, Bäumer B, Ronchi G, Geuna S, Hausott B, Klimaschewski L. | 10/10/2015 |
| Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling. | CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling.
Satoh T, Torii S, Nakayama K, Nishida E. | 07/4/2015 |
| we reveal that SPRY2 expression is regulated by FOXO3a and beta-catenin nuclear activity in colon cancer | SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.
Ordóñez-Morán P, Irmisch A, Barbáchano A, Chicote I, Tenbaum S, Landolfi S, Tabernero J, Huelsken J, Muñoz A, Pálmer HG. | 05/31/2014 |
| Spry1 and Spry2 coordination is required for normal development of the external genitalia in mice | Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.
Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD., Free PMC Article | 03/22/2014 |
| We propose that Sprouty genes(Spry2 and Spry4) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. | The dynamics of supernumerary tooth development are differentially regulated by Sprouty genes.
Lagronova-Churava S, Spoutil F, Vojtechova S, Lesot H, Peterka M, Klein OD, Peterkova R. | 02/15/2014 |
| conjunctival epithelial Spry1 and Spry2 redundantly promote eyelid closure. | Spry1 and Spry2 are necessary for eyelid closure.
Kuracha MR, Siefker E, Licht JD, Govindarajan V., Free PMC Article | 12/28/2013 |
| Findings indicate that leukemia inhibitory factor (LIF)-induced Stat3 phosphorylation plays an important role in promoting the binding of phospho-Erk1/2 and Sprouty2, and thus inhibiting growth factor (FGF)-induced differentiation. | Leukemia inhibitory factor-induced Stat3 signaling suppresses fibroblast growth factor 1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells.
Liu JW, Hsu YC, Kao CY, Su HL, Chiu IM. | 11/2/2013 |
| study thus reveals a novel Spry2 function, which mediates endothelial contact inhibition and barrier integrity | Sprouty2 expression controls endothelial monolayer integrity and quiescence.
Peier M, Walpen T, Christofori G, Battegay E, Humar R. | 09/7/2013 |