| Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene. | Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.
Kuhn T, Kaiser K, Lebek S, Altenhofen D, Knebel B, Herwig R, Rasche A, Pelligra A, Görigk S, Khuong JM, Vogel H, Schürmann A, Blüher M, Chadt A, Al-Hasani H., Free PMC Article | 12/3/2022 |
| Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy. | Cleavage of β-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.
Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu SI, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y. | 09/30/2017 |
| for MD research. The Sgcg(-/-) mice have a more severe phenotype than the mdx mice. Muscle function was assessed by plethysmography and echocardiography. Histologically the Sgcg(-/-) mice displayed increased fibrosis and variable fiber size. | Biochemical and Functional Comparisons of mdx and Sgcg(-/-) Muscular Dystrophy Mouse Models.
Roberts NW, Holley-Cuthrell J, Gonzalez-Vega M, Mull AJ, Heydemann A., Free PMC Article | 03/12/2016 |
| These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus. | Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.
Spinazzola JM, Smith TC, Liu M, Luna EJ, Barton ER., Free PMC Article | 12/26/2015 |
| This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage. | Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex.
Townsend D, Yasuda S, McNally E, Metzger JM., Free PMC Article | 11/12/2011 |
| localization of gamma-SG does not require Tyr(6), but localization alone is insufficient for restoration of normal signal transduction patterns after mechanical perturbation | Restoration of gamma-sarcoglycan localization and mechanical signal transduction are independent in murine skeletal muscle.
Barton ER., Free PMC Article | 06/28/2010 |
| The limb, shoulder, and pelvic muscles of the gsg-/- mice exhibited progressive muscle hypertrophy and weakness with age, and the findings were similar to those seen in other mouse models for limb-girdle and Duchenne muscular dystrophy. | Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice.
Sasaoka T, Imamura M, Araishi K, Noguchi S, Mizuno Y, Takagoshi N, Hama H, Wakabayashi-Takai E, Yoshimoto-Matsuda Y, Nonaka I, Kaneko K, Yoshida M, Ozawa E. | 01/21/2010 |
| Sarcoglycan gamma missense mutations affect sarcoglycan complex assembly and/or localization to the cell surface and provide information on the molecular mechanisms underlying the effects of various sarcoglycan mutations in muscular dystrophies. | Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.
Chen J, Shi W, Zhang Y, Sokol R, Cai H, Lun M, Moore BF, Farber MJ, Stepanchick JS, Bönnemann CG, Chan YM. | 01/21/2010 |
| delta- and gamma-sarcoglycan prevent vascular spasm in coronary arteries and in vascular smooth muscle | Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy.
Wheeler MT, Allikian MJ, Heydemann A, Hadhazy M, Zarnegar S, McNally EM., Free PMC Article | 01/21/2010 |
| sarcoglycan and integrin alpha7beta1 have overlapping roles in mediating cytoskeletal-membrane-extracellular matrix interaction | Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.
Allikian MJ, Hack AA, Mewborn S, Mayer U, McNally EM. | 01/21/2010 |
| In sarcoglycan mutant mice, regionally increased cardiac NO was associated with hypersensitivity to carbachol and decreased sensitivity to adrenergic stimulation. | Functional nitric oxide synthase mislocalization in cardiomyopathy.
Heydemann A, Huber JM, Kakkar R, Wheeler MT, McNally EM. | 01/21/2010 |