| The m[6]A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B. | The m(6)A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B.
Yang Y, Jiang X, Chen J, Liu L, Liu G, Sun K, Liu W, Zhu X, Guan Q. | 02/22/2024 |
| The m[6]A reader YTHDC2 promotes SIRT3 expression by reducing the stabilization of KDM5B to improve mitochondrial metabolic reprogramming in diabetic peripheral neuropathy. | The m(6)A reader YTHDC2 promotes SIRT3 expression by reducing the stabilization of KDM5B to improve mitochondrial metabolic reprogramming in diabetic peripheral neuropathy.
Jiao Y, Wang S, Wang X, Yin L, Zhang YH, Li YZ, Yu YH. | 02/17/2023 |
| Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects. | Mettl3-mediated m(6) A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.
Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A. | 07/2/2022 |
| YTHDC2 is required for meiotic progression through the pachytene stage. Inducible inactivation of YTHDC2 causes a massively dysregulated transcriptome in pachytene cells and altered transcripts in YTHDC2-deficient cells encode microtubule network proteins. Depletion of YTHDC2 leads to telomere clustering in pachytene cells. | YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis.
Liu R, Kasowitz SD, Homolka D, Leu NA, Shaked JT, Ruthel G, Jain D, Lin H, Keeney S, Luo M, Pillai RS, Wang PJ., Free PMC Article | 12/23/2021 |
| N(6) -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | N(6) -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes.
Zhou B, Liu C, Xu L, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H, Lu Y, Ma X. | 06/19/2021 |
| Results suggest that mRNA m(6)A modification and YTHDC2 expression are essential for meiotic initiation and progression in female germ cells. | Critical roles of mRNA m(6)A modification and YTHDC2 expression for meiotic initiation and progression in female germ cells.
Zeng M, Dai X, Liang Z, Sun R, Huang S, Luo L, Li Z. | 08/1/2020 |
| The authors propose that regulation of gene expression by YTHDC2-MEIOC is an evolutionarily ancient strategy for controlling the germline transition into meiosis. | ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.
Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, Keeney S., Free PMC Article | 08/10/2019 |
| The authors show that the mammalian YTHDC2 facilitates a clean switch from mitosis to meiosis in mouse germ cells, revealing a conserved role for YTHDC2 in this critical cell fate transition. | The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.
Bailey AS, Batista PJ, Gold RS, Chen YG, de Rooij DG, Chang HY, Fuller MT., Free PMC Article | 07/7/2018 |
| YTHDC2 is an N(6)-methyladenosine-binding protein that plays critical roles during spermatogenesis. | Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis.
Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C., Free PMC Article | 05/26/2018 |
| studies reveal a role for YTHDC2 in modulating the levels of m(6)A-modified germline transcripts to maintain a gene expression program that is conducive for progression through meiosis. | Regulation of m(6)A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.
Wojtas MN, Pandey RR, Mendel M, Homolka D, Sachidanandam R, Pillai RS. | 10/28/2017 |
| We conclude that when the meiotic chromosomal program is initiated, Meioc is simultaneously induced so as to extend meiotic prophase. Specifically, MEIOC, together with YTHDC2, promotes a meiotic (as opposed to mitotic) cell cycle program via post-transcriptional control of their target transcripts. | Meioc maintains an extended meiotic prophase I in mice.
Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC., Free PMC Article | 05/20/2017 |