| Microglial Gi-dependent dynamics regulate brain network hyperexcitability. | Microglial G(i)-dependent dynamics regulate brain network hyperexcitability.
Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T Jr, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K., Free PMC Article | 03/13/2021 |
| Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors. | Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.
Kolesnikov AV, Chrispell JD, Osawa S, Kefalov VJ, Weiss ER., Free PMC Article | 10/3/2020 |
| We conclude that, in addition to their well-established roles in Meta II inactivation, Grk1 and Arr1 can modulate the kinetics of Meta III decay and rod dark adaptation in vivo. | Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.
Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L 4th, Koutalos Y, Kefalov VJ, Cornwall MC., Free PMC Article | 11/25/2017 |
| The retinal phenotype of Grk1-/- mice is compromised by a Crb1 rd8 mutation. | The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.
Pak JS, Lee EJ, Craft CM., Free PMC Article | 06/28/2016 |
| Rods and cones share the same isoforms of recoverin and GRK1, and photoactivation also triggers a calcium decline in cones | Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.
Sakurai K, Chen J, Khani SC, Kefalov VJ., Free PMC Article | 06/20/2015 |
| Knockout of Unc119 partially reversed the transport defect of GRK1 in cone photoreceptors caused by deletion of Pde6d. | Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.
Zhang H, Frederick JM, Baehr W., Free PMC Article | 07/26/2014 |
| rhodopsin kinase may modulate the decay of light-activated PDE*, which may be responsible for the quickening of response recovery in background light. | Modulation of mouse rod response decay by rhodopsin kinase and recoverin.
Chen CK, Woodruff ML, Chen FS, Chen Y, Cilluffo MC, Tranchina D, Fain GL., Free PMC Article | 01/26/2013 |
| Altering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude. | Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
Sakurai K, Young JE, Kefalov VJ, Khani SC., Free PMC Article | 11/5/2011 |
| phototransduction does not play a direct role in the light-dependent dephosphorylation of GRK1. | Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
Osawa S, Jo R, Xiong Y, Reidel B, Tserentsoodol N, Arshavsky VY, Iuvone PM, Weiss ER., Free PMC Article | 08/6/2011 |
| PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension. | Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.
Kouchi Z, Igarashi T, Shibayama N, Inanobe S, Sakurai K, Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, Fukami K., Free PMC Article | 05/14/2011 |
| The results of this study demonstrated a light-independent mechanism for retinal degeneration in the absence of GRK1, suggesting a second, not previously recognized role for that kinase. | Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism.
Fan J, Sakurai K, Chen CK, Rohrer B, Wu BX, Yau KW, Kefalov V, Crouch RK., Free PMC Article | 03/22/2010 |
| PKA and GRK phosphorylation of the beta(2)AR has distinct roles for agonist dose-dependent coupling to G(i) proteins in cardiac myocytes | Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.
Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y., Free PMC Article | 01/21/2010 |
| study revealed that arrestin, in addition to its role in quenching the activity of rhodopsin, can tune the kinetics of rhodopsin phosphorylation by competing with GRK1 | Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors.
Doan T, Azevedo AW, Hurley JB, Rieke F., Free PMC Article | 01/21/2010 |
| Nrl and Grk1 have roles in photoresponse recovery and age-related degeneration | Slowed photoresponse recovery and age-related degeneration in cones lacking G protein-coupled receptor kinase 1.
Zhu X, Brown B, Rife L, Craft CM., Free PMC Article | 01/21/2010 |
| The conserved short enhancer/promoter immediately upstream of the Rk gene contains the key elements required for appropriate response to spatial and temporal cues during photoreceptor cell differentiation and fate determination. | Conserved structure and spatiotemporal function of the compact rhodopsin kinase (GRK1) enhancer/promoter.
Young JE, Gross KW, Khani SC. | 01/21/2010 |
| transport of prenylated proteins, particularly GRK1 and cone phosphodiesterase, to rod and cone outer segments | Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.
Zhang H, Li S, Doan T, Rieke F, Detwiler PB, Frederick JM, Baehr W., Free PMC Article | 01/21/2010 |