| ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity. | ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
Ranjit S, Wang Y, Zhu J, Cheepala SB, Schuetz EG, Cho WJ, Xu B, Robinson CG, Wu G, Naren AP, Schuetz JD., | 01/10/2024 |
| ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target. | ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target.
Yerushalmi GM, Shuraki B, Yung Y, Maman E, Baum M, Hennebold JD, Adashi EY, Hourvitz A. | 03/27/2023 |
| Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets. | Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
Belleville-Rolland T, Leuci A, Mansour A, Decouture B, Martin F, Poirault-Chassac S, Rouaud M, Guerineau H, Dizier B, Pidard D, Gaussem P, Bachelot-Loza C. | 03/19/2022 |
| Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III. | Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Chatterjee S, Mukherjee S, Sankara Sivaprasad LVJ, Naik T, Gautam SS, Murali BV, Hadambar AA, Gunti GR, Kuchibhotla V, Deyati A, Basavanthappa S, Ramarao M, Mariappan TT, Zinker BA, Zhang Y, Sinz M, Shen H. | 02/13/2021 |
| An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling. | An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
Wijaya J, Vo BT, Liu J, Xu B, Wu G, Wang Y, Peng J, Zhang J, Janke LJ, Orr BA, Yu J, Roussel MF, Schuetz JD., Free PMC Article | 10/24/2020 |
| cyclic AMP efflux via MRP4 plays an essential role in mouse sperm capacitation. | MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation.
Alonso CAI, Lottero-Leconte R, Luque GM, Vernaz ZJ, Di Siervi N, Gervasi MG, Buffone MG, Davio C, Perez-Martinez S. | 07/11/2020 |
| TNFalpha induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway. | TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis.
Lian W, Liu X, Chen W., Free PMC Article | 12/21/2019 |
| The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse. | A novel exon generates ubiquitously expressed alternatively spliced new transcript of mouse Abcc4 gene.
Rehman SU, Ishqi HM, Husain MA, Sarwar T, Tabish M. | 01/28/2017 |
| ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells. | ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.
Drenberg CD, Hu S, Li L, Buelow DR, Orwick SJ, Gibson AA, Schuetz JD, Sparreboom A, Baker SD., Free PMC Article | 11/19/2016 |
| P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier | Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.
Chapy H, Saubaméa B, Tournier N, Bourasset F, Behar-Cohen F, Declèves X, Scherrmann JM, Cisternino S., Free PMC Article | 11/5/2016 |
| These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents. | The ABCC4 membrane transporter modulates platelet aggregation.
Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD., Free PMC Article | 02/27/2016 |
| A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors. | PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.
Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP., Free PMC Article | 02/20/2016 |
| Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis | Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.
Decouture B, Dreano E, Belleville-Rolland T, Kuci O, Dizier B, Bazaa A, Coqueran B, Lompre AM, Denis CV, Hulot JS, Bachelot-Loza C, Gaussem P., Free PMC Article | 01/23/2016 |
| Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway | Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.
Maeng HJ, Lee WJ, Jin QR, Chang JE, Shim WS. | 04/4/2015 |
| role of MRP4 in thrombus formation | Multidrug resistance protein 4 (MRP4/ABCC4) regulates thrombus formation in vitro and in vivo.
Lien LM, Chen ZC, Chung CL, Yen TL, Chiu HC, Chou DS, Huang SY, Sheu JR, Lu WJ, Lin KH. | 02/14/2015 |
| NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules. | Na⁺/H⁺ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney.
Park J, Kwak JO, Riederer B, Seidler U, Cole SP, Lee HJ, Lee MG., Free PMC Article | 05/31/2014 |
| Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid. | Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib.
Furmanski BD, Hu S, Fujita KI, Li L, Gibson AA, Janke LJ, Williams RT, Schuetz JD, Sparreboom A, Baker SD., Free PMC Article | 04/5/2014 |
| Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS or CS exposure or of eosinophils after allergen exposure | The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.
Schymeinsky J, Mayer H, Tomsic C, Tilp C, Schuetz JD, Cui Y, Wollin L, Gantner F, Erb KJ., Free PMC Article | 11/30/2013 |
| Data indicate that Abcc4 limits the brain penetration of camptothecin analogues and teams up with Abcb1a/b and Abcg2 to form a robust cooperative drug efflux system. | Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues.
Lin F, Marchetti S, Pluim D, Iusuf D, Mazzanti R, Schellens JH, Beijnen JH, van Tellingen O. | 11/16/2013 |
| Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. | Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.
Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP., Free PMC Article | 04/20/2013 |
| Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively. | Oral availability of cefadroxil depends on ABCC3 and ABCC4.
de Waart DR, van de Wetering K, Kunne C, Duijst S, Paulusma CC, Oude Elferink RP. | 08/11/2012 |
| We have shown, for the first time, a role for MRP4 in the regulation of cAMP in cardiac myocytes and involvement of CFTR in beta-adrenergic stimulated contraction | MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes.
Sellers ZM, Naren AP, Xiang Y, Best PM., Free PMC Article | 07/21/2012 |
| analysis of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin | Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.
Marquez B, Ameye G, Vallet CM, Tulkens PM, Poirel HA, Van Bambeke F., Free PMC Article | 07/21/2012 |
| Mrp4 is required for normal Leydig cell testosterone production. | Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice.
Morgan JA, Cheepala SB, Wang Y, Neale G, Adachi M, Nachagari D, Leggas M, Zhao W, Boyd K, Venkataramanan R, Schuetz JD., Free PMC Article | 07/7/2012 |
| Data show that MRP4 is the predominant isoform present at the plasma membrane of cardiacmyocytes and that it mediates the efflux of cAMP. | Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.
Sassi Y, Abi-Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, Kranias EG, Marks AR, Lacampagne A, Engelhardt S, Hatem SN, Lompre AM, Hulot JS., Free PMC Article | 05/26/2012 |