| Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms. | Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
Zhang P, You N, Ding Y, Zhu W, Wang N, Xie Y, Huang W, Ren Q, Qin T, Fu R, Zhang L, Xiao Z, Cheng T, Ma X., Free PMC Article | 04/10/2024 |
| Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation. | Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
Zhang L, Li Q, Wang H, Wu Y, Ye X, Gong Z, Li Q, Xuan A. | 05/14/2022 |
| MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling. | MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Wan X, Yao B, Ma Y, Liu Y, Tang Y, Hu J, Li M, Fu S, Zheng X, Yin D. | 02/27/2021 |
| Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g. | Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
Apulei J, Kim N, Testa D, Ribot J, Morizet D, Bernard C, Jourdren L, Blugeon C, Di Nardo AA, Prochiantz A. | 09/26/2020 |
| Mimicking Age-Associated Gadd45gamma Dysregulation Results in Memory Impairments in Young Adult Mice. | Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice.
Brito DVC, Kupke J, Gulmez Karaca K, Zeuch B, Oliveira AMM., Free PMC Article | 08/22/2020 |
| during fear learning, Gadd45gamma serves to act as a coordinator of immediate early gene expression and subsequent memory consolidation by directing temporally specific changes in active DNA demethylation at the promoter of plasticity-related immediate early genes | The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.
Li X, Marshall PR, Leighton LJ, Zajaczkowski EL, Wang Z, Madugalle SU, Yin J, Bredy TW, Wei W., Free PMC Article | 12/14/2019 |
| PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression. | Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression.
Zhao L, Li S, Gan L, Li C, Qiu Z, Feng Y, Li J, Li L, Li C, Peng W, Xu C, Wang Z, Hui T, Ren G, Tao Q, Xiang T., Free PMC Article | 01/14/2017 |
| accumulation during myocardial infarction promotes the development and persistence of heart failure by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner | Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling.
Lucas A, Mialet-Perez J, Daviaud D, Parini A, Marber MS, Sicard P. | 08/13/2016 |
| Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity | Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex.
Matsunaga E, Nambu S, Oka M, Iriki A. | 01/16/2016 |
| The Gadd45g-d4Venus mice exhibited very similar labeling patterns in the ventricular zone (VZ), in Gadd45g-d4Venus mice cells could be visualized in more basal areas containing fully differentiated neurons. | Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain.
Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T., Free PMC Article | 02/21/2015 |
| Identify growth arrest and DNA-damage-inducible protein 45 gamma (GADD45gamma) as a cold-induced activator of uncoupling protein 1 (UCP1) and oxidative capacity in brown adipose tissue. | GADD45γ regulates the thermogenic capacity of brown adipose tissue.
Gantner ML, Hazen BC, Conkright J, Kralli A., Free PMC Article | 10/25/2014 |
| GADD45G functions as a negative regulator of the Jak-Stat3 pathway and inhibits hepatocellular carcinoma by inducing cellular senescence. | Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma.
Zhang L, Yang Z, Ma A, Qu Y, Xia S, Xu D, Ge C, Qiu B, Xia Q, Li J, Liu Y. | 03/8/2014 |
| Gadd45g as a candidate gene for male infertility and 46,XY sex reversal in humans | Gadd45g is essential for primary sex determination, male fertility and testis development.
Johnen H, González-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM., Free PMC Article | 09/21/2013 |
| suggest that a signaling cascade, involving GADD45G --> p38 MAPK --> GATA4 --> SRY, regulates male sex determination | GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.
Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C. | 02/2/2013 |
| suggest a requirement for GADD45gamma in promoting MAP3K4-mediated activation of p38 MAPK signaling in embryonic gonadal somatic cells for testis determination | Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.
Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A., Free PMC Article | 02/2/2013 |
| Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. | Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.
Kaufmann LT, Gierl MS, Niehrs C. | 02/25/2012 |
| Results identify Gadd45gamma as a direct transcriptional target of Ascl1. | Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
Huang HS, Kubish GM, Redmond TM, Turner DL, Thompson RC, Murphy GG, Uhler MD., Free PMC Article | 10/4/2010 |
| members of the Gadd45 gene family are important for anti-tumor immune responses. | Gadd45b and Gadd45g are important for anti-tumor immune responses.
Ju S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B., Free PMC Article | 03/1/2010 |
| The crystal structure of Gadd45gamma, which reveals a fold comprising an alphabetaalpha sandwich with a central five-stranded mixed beta-sheet with alpha-helices packed on either side, is reported. | The crystal structure and dimerization interface of GADD45gamma.
Schrag JD, Jiralerspong S, Banville M, Jaramillo ML, O'Connor-McCourt MD., Free PMC Article | 01/21/2010 |
| GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. | GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
Vairapandi M, Balliet AG, Hoffman B, Liebermann DA. | 01/21/2010 |
| Gadd45gamma plays a critical role in the resolution of immune responses that prevent autoimmunity | Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity.
Liu L, Tran E, Zhao Y, Huang Y, Flavell R, Lu B., Free PMC Article | 01/21/2010 |
| localization of the Gadd45g gene to mouse chromosome band 13A5-B, which has been reported to contain a quantitative trait locus that regulates body weight | Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene.
Balliet AG, Hollander MC, Fornace AJ Jr, Hoffman B, Liebermann DA. | 01/21/2010 |
| are induced by acute hypertonicity in murine kidney collecting duct cells. | Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells.
Chakravarty D, Cai Q, Ferraris JD, Michea L, Burg MB, Kültz D. | 01/21/2010 |
| Gadd45gamma induction strongly potentiates apoptosis | Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress.
Mak SK, Kültz D. | 01/21/2010 |
| During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented interferon-gamma production in a process independent of STAT4. | GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA., Free PMC Article | 01/21/2010 |