| ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. | ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia.
Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H., Free PMC Article | 08/6/2022 |
| Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function. | Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function.
Böning MAL, Parzmair GP, Jeron A, Düsedau HP, Kershaw O, Xu B, Relja B, Schlüter D, Dunay IR, Reinhold A, Schraven B, Bruder D., Free PMC Article | 12/25/2021 |
| ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages. | ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Yang N, Xiong Y, Wang Y, Yi Y, Zhu J, Ma F, Li J, Liu H. | 07/24/2021 |
| Results demonstrated that loss of ADAP restricted to the megakaryocytic lineage, has no impact on other hematopoietic cells, causes thrombocytopenia and reduced plasma levels of PF4 and TGF-beta1, impairs CLEC-2-mediated platelet activation in vitro, and results in enhanced experimental autoimmune encephalomyelitis severity. | Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP.
Rudolph JM, Guttek K, Weitz G, Meinke CA, Kliche S, Reinhold D, Schraven B, Reinhold A., Free PMC Article | 02/5/2020 |
| Adap(-/-) mice have moderate thrombocytopenia and smaller platelets. Adap(-/-) platelets had a shorter life span than controlss. Cultured ADAP(-) BM-derived MKs had reduced spreading on extracellular matrix proteins and beta1 integrin activation, impaired podosome formation, and defective polarization of the demarcation membrane system. ADAP has an unspecified role in the process of MK polarization and platelet biogene... | ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
Spindler M, van Eeuwijk JMM, Schurr Y, Nurden P, Nieswandt B, Stegner D, Reinhold A, Bender M. | 07/20/2019 |
| ADAP fulfills different functions in CD4(+) and CD8(+) T cells, with CD8(+) T cells being less dependent on ADAP. | ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D. | 09/9/2017 |
| ADAP regulates CD8 T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues. | Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection.
Fiege JK, Beura LK, Burbach BJ, Shimizu Y., Free PMC Article | 08/12/2017 |
| Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 production and TGFbeta1-induced CD103 expression in CD8+ T-lymphocytes and protects against influenza H5N1 virus infection. | The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
Li C, Jiao S, Wang G, Gao Y, Liu C, He X, Zhang C, Xiao J, Li W, Zhang G, Wei B, Chen H, Wang H., Free PMC Article | 04/2/2016 |
| The results indicate that ADAP dampens naive CD8 T cell responses to lymphopenia and IL-15, and they demonstrate a novel Ag-independent function for ADAP in the suppression of memory phenotype CD8 T cell generation. | Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
Fiege JK, Burbach BJ, Shimizu Y., Free PMC Article | 02/6/2016 |
| provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively. | TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.
Thaker YR, Schneider H, Rudd CE., Free PMC Article | 09/26/2015 |
| ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. | ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ., Free PMC Article | 07/19/2014 |
| we demonstrate that loss of ADAP promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1+ lymphatic structures. | T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice.
Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A. | 01/18/2014 |
| Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. | Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Rajasekaran K, Kumar P, Schuldt KM, Peterson EJ, Vanhaesebroeck B, Dixit V, Thakar MS, Malarkannan S., Free PMC Article | 12/14/2013 |
| integrin activation by the ADAP-SKAP55-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation. | Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling module.
Mitchell JS, Burbach BJ, Srivastava R, Fife BT, Shimizu Y., Free PMC Article | 11/16/2013 |
| ADAP coordinates distinct CARMA1-dependent control of key cell cycle proteins in T cells | ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.
Srivastava R, Burbach BJ, Mitchell JS, Pagán AJ, Shimizu Y., Free PMC Article | 07/6/2013 |
| The authors utilize in vitro systems to map novel phosphotyrosine sites in the C-terminal part of human ADAP (486-783). They found many phospho-dependent binding partners of ADAP and confirmed the interaction between ADAP and Nck, indicating that ADAP directly links integrins to modulators of the cytoskeleton independent of SLP-76. | Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Grossmann A, Stelzl U, Schraven B, Krause E, Freund C., Free PMC Article | 05/20/2013 |
| ADAP plays a role in mediating platelet activation via the collagen-binding integrin alpha(2) beta(1). | A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
Jarvis GE, Bihan D, Hamaia S, Pugh N, Ghevaert CJ, Pearce AC, Hughes CE, Watson SP, Ware J, Rudd CE, Farndale RW., Free PMC Article | 06/16/2012 |
| SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced acute kidney injury in humans. | Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A., Free PMC Article | 04/7/2012 |
| TM4SF10, possibly through ADAP, may regulate Fyn activity | TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Azhibekov TA, Wu Z, Padiyar A, Bruggeman LA, Simske JS., Free PMC Article | 01/21/2012 |
| Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP. | The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.
Burbach BJ, Srivastava R, Ingram MA, Mitchell JS, Shimizu Y., Free PMC Article | 08/13/2011 |
| HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion. | HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Patzak IM, Königsberger S, Suzuki A, Mak TW, Kiefer F. | 01/1/2011 |
| the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation | NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.
Srivastava R, Burbach BJ, Shimizu Y., Free PMC Article | 05/10/2010 |
| ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress. | Role for ADAP in shear flow-induced platelet mechanotransduction.
Kasirer-Friede A, Ruggeri ZM, Shattil SJ., Free PMC Article | 04/19/2010 |
| Findings provide evidence of an obligatory role for the SLP-76-ADAP module in LFA-1-mediated costimulation in T cells. | SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.
Wang H, Wei B, Bismuth G, Rudd CE., Free PMC Article | 01/21/2010 |
| A small region of the ADAP proline-rich domain is required for rescue of SKAP55 expression by ADAP-deficient T cells, as well as for optimal antigen-dependent T cell:antigen presenting cell conjugate formation and downstream T cell activation. | Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.
Burbach BJ, Srivastava R, Medeiros RB, O'Gorman WE, Peterson EJ, Shimizu Y., Free PMC Article | 01/21/2010 |