| Odor sampling strategies in mice with genetically altered olfactory responses. | Odor sampling strategies in mice with genetically altered olfactory responses.
Reisert J, Golden GJ, Dibattista M, Gelperin A., Free PMC Article | 10/9/2021 |
| Thus, despite its relative abundance in the lens, Nckx4 does not appear to have an indispensable role in the maintenance of lens clarity. | Expression of potassium-dependent sodium-calcium exchanger in the murine lens.
De Maria A, Zhao H, Bassnett S., Free PMC Article | 10/6/2018 |
| The authors show that NCKX4 shapes the cone photoresponse together with the cone-specific NCKX2: NCKX4 acts early to limit response amplitude, while NCKX2 acts late to further accelerate response recovery. The regulation of Ca(2+) by NCKX4 in cones is a novel mechanism that supports their ability to function as daytime photoreceptors and promotes their survival. | The Na(+)/Ca(2+), K(+) exchanger NCKX4 is required for efficient cone-mediated vision.
Vinberg F, Wang T, De Maria A, Zhao H, Bassnett S, Chen J, Kefalov VJ., Free PMC Article | 03/24/2018 |
| immunostaining of the apical plasma membranes of fluorotic ameloblasts was strongly reduced or absent suggesting that trafficking of NCKX4 to the apical membrane was strongly reduced | Reduced Protein Expression of the Na(+)/Ca(2+)+K(+)-Exchanger (SLC24A4) in Apical Plasma Membranes of Maturation Ameloblasts of Fluorotic Mice.
Bronckers AL, Jalali R, Lytton J., Free PMC Article | 02/3/2018 |
| olfactory sensory neurons in NCKX4(-/-);CNGB1(DeltaCaM) mice displayed markedly reduced electro-olfactogram amplitude accompanied by alterations in other response attributes | Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.
Ferguson CH, Zhao H., Free PMC Article | 07/29/2017 |
| pigment cells express robust, functional NCKX4 activity | Identification and Characterization of K(+)-Dependent Na(+)-Ca(2+) Exchange Transport in Pigmented MEB4 Cells Mediated by NCKX4.
Szerencsei RT, Ginger RS, Green MR, Schnetkamp PP. | 04/29/2017 |
| These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4-mediated Ca(2+) extrusion in controlling MC4R signaling | An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety.
Li XF, Lytton J., Free PMC Article | 02/21/2015 |
| NCKX4 activity is stimulated by ATP through activation of the P2Y receptor signalling pathway. | Purinergic stimulation of K+-dependent Na+/Ca2+ exchanger isoform 4 requires dual activation by PKC and CaMKII.
Yang X, Lytton J., Free PMC Article | 08/9/2014 |
| NCKX4 might be an important regulator of Ca(2+) transport during amelogenesis. | Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts.
Hu P, Lacruz RS, Smith CE, Smith SM, Kurtz I, Paine ML., Free PMC Article | 07/13/2013 |
| These findings support a key role for SLC24A4 in calcium transport during enamel formation. | Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis imperfecta.
Parry DA, Poulter JA, Logan CV, Brookes SJ, Jafri H, Ferguson CH, Anwari BM, Rashid Y, Zhao H, Johnson CA, Inglehearn CF, Mighell AJ., Free PMC Article | 04/6/2013 |
| These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception. | The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response.
Stephan AB, Tobochnik S, Dibattista M, Wall CM, Reisert J, Zhao H., Free PMC Article | 02/18/2012 |