| Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner. | Enhanced Akt3 kinase activity reduces atherosclerosis in hyperlipidemic mice in a gender-dependent manner.
Zhang L, Altemus J, Ding L, Cherepanova O, Byzova TV, Podrez EA., Free PMC Article | 01/3/2024 |
| miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO2-Induced Lung Fibrosis. | miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in SiO(2)-Induced Lung Fibrosis.
Li P, Hao X, Liu J, Zhang Q, Liang Z, Li X, Liu H., Free PMC Article | 08/16/2023 |
| The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway. | The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Wang B, Zhang M, Guo J, Liu Z, Zhou R, Guo F, Li K, Mu Y., Free PMC Article | 12/18/2021 |
| Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1. | Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1.
Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang JJ, Hu Y, Chen G., Free PMC Article | 11/27/2021 |
| Akt3-mTOR regulates hippocampal neurogenesis in adult mouse. | Akt3-mTOR regulates hippocampal neurogenesis in adult mouse.
Zhang T, Ding H, Wang Y, Yuan Z, Zhang Y, Chen G, Xu Y, Chen L. | 11/22/2021 |
| Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals. | Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.
Tang B, Li W, Ji TT, Li XY, Qu X, Feng L, Bai S., Free PMC Article | 05/15/2021 |
| AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling. | AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling.
Gu S, Dai H, Zhao X, Gui C, Gui J., Free PMC Article | 02/27/2021 |
| Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox). | Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox).
Polytarchou C, Hatziapostolou M, Yau TO, Christodoulou N, Hinds PW, Kottakis F, Sanidas I, Tsichlis PN., Free PMC Article | 01/16/2021 |
| Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency. | Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency.
Zhao J, Zhu L, Wijesekera N, Jones C., Free PMC Article | 01/2/2021 |
| Depletion of Siah1 enhanced Akt3 levels in the soma and axonal tips, eliciting multiple branching. | SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
Ko HR, Jin EJ, Lee SB, Kim CK, Yun T, Cho SW, Park KW, Ahn JY., Free PMC Article | 06/27/2020 |
| glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells. | AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
Zhang X, Wei R, Sun Y, Xia Q, Xie W, Song H, Wang W, Zou K. | 06/27/2020 |
| Long-term spatial memory was impaired in Akt3-KO mice, but not in Akt1-KO mice. | Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR.
Zhang T, Shi Z, Wang Y, Wang L, Zhang B, Chen G, Wan Q, Chen L. | 03/21/2020 |
| High AKT3 expression is associated with adenoid cystic carcinoma development in salivary glands. | AKT3 drives adenoid cystic carcinoma development in salivary glands.
Zboray K, Mohrherr J, Stiedl P, Pranz K, Wandruszka L, Grabner B, Eferl R, Moriggl R, Stoiber D, Sakamoto K, Wagner KU, Popper H, Casanova E, Moll HP., Free PMC Article | 05/25/2019 |
| Findings using a mouse model with genetic deletion of Akt3 demonstrate that the specific isoform Akt3 throughout the Akt3/GSK-3 pathway is involved during motor learning. | Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice.
Ouimet B, Pépin É, Bergeron Y, Chagniel L, Beaulieu JM, Massicotte G, Cyr M. | 03/23/2019 |
| The authors find in Mus musculus, each AKT isoform has a unique expression pattern in the hippocampus. AKT1, but not AKT2 or AKT3, is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT activity inhibits mGluR-LTD, with overlapping functions for AKT1 and AKT3. | AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.
Levenga J, Wong H, Milstead RA, Keller BN, LaPlante LE, Hoeffer CA., Free PMC Article | 07/7/2018 |
| Behavioral data on Akt3-/- and Akt1-/- mice demonstrated that Akt3 but not Akt1 is required for spatial learning. Histological analyses on synapse, dendrite, and myelin markers suggested that Akt3 but not Akt1 is important for the white matter integrity, and that Akt single isoform does not play a pivotal role on neuronal survival. | Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice.
Wang H, Zhang BF, Zhang TT, Wang L, Zou XY, Xu Y, Chen L, Chen GQ., Free PMC Article | 06/9/2018 |
| Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model. | V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Valls Serón M, Ferwerda B, Engelen-Lee J, Geldhoff M, Jaspers V, Zwinderman AH, Tanck MW, Baas F, van der Ende A, Brouwer MC, van de Beek D., Free PMC Article | 10/28/2017 |
| findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT/mTOR signaling in brain | PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia.
Howell KR, Floyd K, Law AJ., Free PMC Article | 09/23/2017 |
| these results indicate that PI3K and Akt ( Akt1-Akt3)play distinct roles, and that PI3K stimulates Akt-independent pathways that are important for GLUT4 translocation. | Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.
Xu Y, Nan D, Fan J, Bogan JS, Toomre D., Free PMC Article | 08/5/2017 |
| miR-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway. | MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
Zhu LP, Zhou JP, Zhang JX, Wang JY, Wang ZY, Pan M, Li LF, Li CC, Wang KK, Bai YP, Zhang GG. | 06/24/2017 |
| Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway. | Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway.
Ding L, Zhang L, Kim M, Byzova T, Podrez E., Free PMC Article | 06/10/2017 |
| The predominant AKT isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT-induced axon regeneration. | mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system.
Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y., Free PMC Article | 12/24/2016 |
| Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4. | Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4.
Grottke A, Ewald F, Lange T, Nörz D, Herzberger C, Bach J, Grabinski N, Gräser L, Höppner F, Nashan B, Schumacher U, Jücker M., Free PMC Article | 07/2/2016 |
| In viable Akt three-isoforms conditional knockout mice, total Akt levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice. | Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain.
Wang L, Cheng S, Yin Z, Xu C, Lu S, Hou J, Yu T, Zhu X, Zou X, Peng Y, Xu Y, Yang Z, Chen G., Free PMC Article | 03/26/2016 |
| untreated Akt1 and Akt2/Akt3 double knockout mice display significant hearing loss, indicating a role for these isoforms in normal hearing. | All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.
Brand Y, Levano S, Radojevic V, Naldi AM, Setz C, Ryan AF, Pak K, Hemmings BA, Bodmer D., Free PMC Article | 03/5/2016 |