| Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103[+] dendritic cell IL-23-dependent ileocolitis. | Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103(+) dendritic cell IL-23-dependent ileocolitis.
Viladomiu M, Khounlotham M, Dogan B, Lima SF, Elsaadi A, Cardakli E, Castellanos JG, Ng C, Herzog J, Schoenborn AA, Ellermann M, Liu B, Zhang S, Gulati AS, Sartor RB, Simpson KW, Lipkin SM, Longman RS., Free PMC Article | 11/26/2022 |
| Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT. | Tumour-associated neutrophils secrete AGR2 to promote colorectal cancer metastasis via its receptor CD98hc-xCT.
Tian S, Chu Y, Hu J, Ding X, Liu Z, Fu D, Yuan Y, Deng Y, Wang G, Wang L, Wang Z. | 11/12/2022 |
| Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease. | Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease.
Al-Shaibi AA, Abdel-Motal UM, Hubrack SZ, Bullock AN, Al-Marri AA, Agrebi N, Al-Subaiey AA, Ibrahim NA, Charles AK, COLORS in IBD-Qatar Study Group, Elawad M, Uhlig HH, Lo B., Free PMC Article | 04/2/2022 |
| AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53. | AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53.
Zhang Z, Li H, Deng Y, Schuck K, Raulefs S, Maeritz N, Yu Y, Hechler T, Pahl A, Fernández-Sáiz V, Wan Y, Wang G, Engleitner T, Öllinger R, Rad R, Reichert M, Diakopoulos KN, Weber V, Li J, Shen S, Zou X, Kleeff J, Mihaljevic A, Michalski CW, Algül H, Friess H, Kong B. | 01/22/2022 |
| Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation. | Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation.
Wang Y, Jia M, Liang C, Sheng N, Wang X, Wang F, Luo Y, Jiang J, Cai L, Niu H, Zhu D, Nesa EU, Young CY, Yuan H., Free PMC Article | 01/22/2022 |
| Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to beta-catenin that requires AGR2 dimerization and adhesion domains. | Extracellular AGR2 activates neighboring fibroblasts through endocytosis and direct binding to β-catenin that requires AGR2 dimerization and adhesion domains.
Merugu SB, Zhou B, Mangukiya HB, Negi H, Ghulam R, Roy D, Qudsia S, Wang Z, Mashausi DS, Yunus FU, Liu GS, Li D. | 11/22/2021 |
| secretory AGR2 alters fibroblasts elongation, migration, and organization suggesting the secretory AGR2 as a potential molecular target that might be responsible to alter fibroblasts infiltration to support tumor growth. | Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration.
Mangukiya HB, Negi H, Merugu SB, Sehar Q, Mashausi DS, Yunus FU, Wu Z, Li D., Free PMC Article | 05/23/2020 |
| study demonstrates that AGR2 dimers act as sensors of ER homeostasis which are disrupted upon ER stress and promote the secretion of AGR2 monomers. | Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.
Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E., Free PMC Article | 04/25/2020 |
| AGR2 accelerates skin wound healing through regulation of cell migration. | Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.
Zhu Q, Mangukiya HB, Mashausi DS, Guo H, Negi H, Merugu SB, Wu Z, Li D. | 11/4/2017 |
| AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation. | ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP, Heeschen C, Esposito I, Lemoine NR, Crnogorac-Jurcevic T., Free PMC Article | 09/30/2017 |
| impact of AGR2 expression and EGFR signaling on tissue regeneration | Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
Wodziak D, Dong A, Basin MF, Lowe AW., Free PMC Article | 06/10/2017 |
| EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression. | Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface.
Dong A, Wodziak D, Lowe AW., Free PMC Article | 06/6/2015 |
| AGR2 has both intracellular and extracellular effects in the intestine | AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus.
Bergström JH, Berg KA, Rodríguez-Piñeiro AM, Stecher B, Johansson ME, Hansson GC., Free PMC Article | 04/18/2015 |
| Results indicate that DNA methylation within the AGR2 promoter modulates more aggressive cancer cell phenotypes. | Aberrant hypomethylation-mediated AGR2 overexpression induces an aggressive phenotype in ovarian cancer cells.
Sung HY, Choi EN, Lyu D, Park AK, Ju W, Ahn JH. | 02/14/2015 |
| It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13. | Effect of dexamethasone on expression of AGR2 protein in asthmatic mice.
Zhou M, Chen HL, Cheng S, Mei L, Zhang HL, Xie M, Xiong WN, Xu YJ. | 09/13/2014 |
| Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells. | Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach.
Gupta A, Wodziak D, Tun M, Bouley DM, Lowe AW., Free PMC Article | 04/20/2013 |
| Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells. | The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.
Verma S, Salmans ML, Geyfman M, Wang H, Yu Z, Lu Z, Zhao F, Lipkin SM, Andersen B., Free PMC Article | 11/3/2012 |
| Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). | Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
Li S, Wang Y, Zhang Y, Lu MM, DeMayo FJ, Dekker JD, Tucker PW, Morrisey EE., Free PMC Article | 09/8/2012 |
| studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease | Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice.
Zhao F, Edwards R, Dizon D, Afrasiabi K, Mastroianni JR, Geyfman M, Ouellette AJ, Andersen B, Lipkin SM., Free PMC Article | 04/12/2010 |
| AGR2 is a unique member of the protein disulfide isomerase family, with a specialized and nonredundant role in intestinal mucus production | The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.
Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ., Free PMC Article | 01/21/2010 |
| Overexpression of Agr2 is associated with asthma. | New asthma biomarkers: lessons from murine models of acute and chronic asthma.
Di Valentin E, Crahay C, Garbacki N, Hennuy B, Guéders M, Noël A, Foidart JM, Grooten J, Colige A, Piette J, Cataldo D. | 01/21/2010 |
| AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. | The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation.
Wang Z, Hao Y, Lowe AW. | 01/21/2010 |