| The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication. | The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication.
Ulupinar P, Çağlayan E, Rayaman E, Nagata K, Turan K. | 05/30/2024 |
| The biology of mitochondrial carrier homolog 2. | The biology of mitochondrial carrier homolog 2.
Zheng X, Chu B. | 03/13/2024 |
| MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion. | MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion.
Goldman A, Mullokandov M, Zaltsman Y, Regev L, Levin-Zaidman S, Gross A., Free PMC Article | 01/29/2024 |
| Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. | Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.
Fischer JA, Monroe TO, Pesce LL, Sawicki KT, Quattrocelli M, Bauer R, Kearns SD, Wolf MJ, Puckelwartz MJ, McNally EM., Free PMC Article | 01/28/2023 |
| The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis. | The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis.
Labbé K, Mookerjee S, Le Vasseur M, Gibbs E, Lerner C, Nunnari J., Free PMC Article | 12/11/2021 |
| Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma. | Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.
Yuan Q, Yang W, Zhang S, Li T, Zuo M, Zhou X, Li J, Li M, Xia X, Chen M, Liu Y., Free PMC Article | 10/2/2021 |
| MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex. | MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF., Free PMC Article | 09/25/2021 |
| Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential. | Stop codon read-through of mammalian MTCH2 leading to an unstable isoform regulates mitochondrial membrane potential.
Manjunath LE, Singh A, Sahoo S, Mishra A, Padmarajan J, Basavaraju CG, Eswarappa SM., Free PMC Article | 04/13/2021 |
| Mitochondrial carrier homolog 2 is necessary for AML survival. | Mitochondrial carrier homolog 2 is necessary for AML survival.
Khan DH, Mullokandov M, Wu Y, Voisin V, Gronda M, Hurren R, Wang X, MacLean N, Jeyaraju DV, Jitkova Y, Xu GW, Laister R, Seneviratne A, Blatman ZM, Ketela T, Bader GD, Marhon SA, De Carvalho DD, Minden MD, Gross A, Schimmer AD. | 02/20/2021 |
| study identified Cav1 and MTCH2 as the molecular targets of DHA and revealed a new link between the upstream Cav1/MTCH2 upregulation and the downstream activation of the cell death pathway involved in the DHA-mediated inhibition of cell viability. | Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation.
Zhang T, Hu Y, Wang T, Cai P., Free PMC Article | 03/17/2018 |
| MTCH2 and cardiolipin participate in the recruitment and integration of tBID into the mitochondrial outer membrane. | Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis.
Raemy E, Montessuit S, Pierredon S, van Kampen AH, Vaz FM, Martinou JC., Free PMC Article | 01/13/2018 |
| The BID-MTCH2 axis regulates the differentiation/apoptosis of stem cells and mitochondrial metabolism. (Review) | BCL-2 family proteins as regulators of mitochondria metabolism.
Gross A. | 08/20/2016 |
| Data indicate that Mtch2 accelerated conformational change in membrane-bound tBid (Bid) enables it to activate Bax. | tBid undergoes multiple conformational changes at the membrane required for Bax activation.
Shamas-Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, Leber B, Andrews DW, Fradin C., Free PMC Article | 11/16/2013 |
| Compares and contrasts all the known human SLC25A* genes and includes functional information. | The mitochondrial transporter family SLC25: identification, properties and physiopathology.
Palmieri F. | 07/2/2013 |
| Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. | Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology.
Bernhard F, Landgraf K, Klöting N, Berthold A, Büttner P, Friebe D, Kiess W, Kovacs P, Blüher M, Körner A. | 06/15/2013 |
| Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2. | The role of obesity-related genetic loci in insulin sensitivity.
Fall T, Arnlöv J, Berne C, Ingelsson E. | 11/17/2012 |
| Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein | Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway.
Katz C, Zaltsman-Amir Y, Mostizky Y, Kollet N, Gross A, Friedler A., Free PMC Article | 07/7/2012 |
| Gene-treatment interactions were observed for short-term weight loss. (MTCH2 rs10838738, Plifestyle*SNP = 0.022) | Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
Delahanty LM, Pan Q, Jablonski KA, Watson KE, McCaffery JM, Shuldiner A, Kahn SE, Knowler WC, Florez JC, Franks PW, Diabetes Prevention Program Research Group., Free PMC Article | 06/16/2012 |
| MTCH2 may play a role in cellular processes underlying obesity | MTCH2 in human white adipose tissue and obesity.
Kulyté A, Rydén M, Mejhert N, Dungner E, Sjölin E, Arner P, Dahlman I. | 11/19/2011 |
| MTCH2 rs 10838738 is associated with higher body mass index. | Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H, Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H. | 09/27/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesMC4R variant is associated with BMI but not response to resistance training in young females.
Orkunoglu-Suer FE, Harmon BT, Gordish-Dressman H, Clarkson PM, Thompson PD, Angelopoulos TJ, Gordon PM, Hubal MJ, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Hoffman EP, Devaney JM. Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.
Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Döring A, Rückert IM, Hinney A, Hebebrand J, Wichmann HE, Hauner H, Illig T, Heid IM. | 06/30/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (4) articlesEvaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.
He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw KT, Ong KK, Wareham NJ, Loos RJ. | 12/2/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (10) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Analyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J. Obesity and diabetes genetic variants associated with gestational weight gain.
Stuebe AM, Lyon H, Herring AH, Ghosh J, Wise A, North KE, Siega-Riz AM. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ, Ong KK, Wareham NJ, Loos RJ. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
Morgan AR, Thompson JM, Murphy R, Black PN, Lam WJ, Ferguson LR, Mitchell EA. Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H, Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, Stefan N, Fritsche A, Häring HU, Staiger H. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, Miyatake N, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Kawamoto M, Ueno T, Hamaguchi K, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
Brandys MK, van Elburg AA, Loos RJF, Bauer F, Hendriks J, van der Schouw YT, Adan RAH. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.
Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, van Vliet-Ostaptchouk JV, Wijmenga C, van der Schouw YT. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW, GIANT Consortium. | 02/11/2009 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN, Genetic Investigation of ANthropometric Traits Consortium., Free PMC Article | 01/11/2009 |
| Mtch2 is a mitochondrial target of tBID and possibly participates in the mitochondrial apoptotic program. | Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.
Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A., Free PMC Article | 01/21/2010 |