| The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation. | The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation.
Paternoster V, Cömert C, Kirk LS, la Cour SH, Fryland T, Fernandez-Guerra P, Stougaard M, Nyengaard JR, Qvist P, Bross P, Børglum AD, Christensen JH., Free PMC Article | 08/20/2022 |
| Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples. | Expression Characteristics and Clinical Correlations of BRD1 in Colorectal Cancer Samples.
Li Z, Wang J, Ji Y, Song F., Free PMC Article | 01/29/2022 |
| HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. | HBO1 is a versatile histone acyltransferase critical for promoter histone acylations.
Xiao Y, Li W, Yang H, Pan L, Zhang L, Lu L, Chen J, Wei W, Ye J, Li J, Li G, Zhang Y, Tan M, Ding J, Wong J., Free PMC Article | 10/9/2021 |
| Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Zhang M, Lei M, Qin S, Dong A, Yang A, Li Y, Loppnau P, Hughes TR, Min J, Liu Y. | 07/3/2021 |
| our data point to a cell type- and a stimulus-specific function of BRD1. Inhibiting BRD1 could have potential beneficial effects in rheumatoid arthritis via decreasing the proliferation of synovial fibroblasts. Anti-inflammatory effects were limited and only observed in monocyte-derived macrophages | Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.
Klein K, Kato M, Frank-Bertoncelj M, Kolling C, Ciurea A, Gay S, Ospelt C., Free PMC Article | 10/26/2019 |
| Results show that interaction of sulfatide with BRD1 induced acetylation and promoted integrin alpha V gene transcription in hepatocellular carcinoma cells. | BRD1-Mediated Acetylation Promotes Integrin αV Gene Expression Via Interaction with Sulfatide.
Cai QQ, Dong YW, Qi B, Shao XT, Wang R, Chen ZY, He BM, Wu XZ. | 08/3/2019 |
| There was no association between SNPs in the BRD1 and ZBED4 genes and schizophrenia in the Chinese population. | No association of BRD1 and ZBED4 polymorphisms with schizophrenia in the Chinese Han population.
Xu F, Bi Y, Ren D, Zhu Y, Hu J, Yuan F, Yuan R, Ma G, Niu W, Guo Z, Sun Q, Wu X, Cao Y, Yang F, He L, Yu T, Cai L, He G. | 12/22/2018 |
| TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers. | CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation.
Wakula P, Neumann B, Kienemund J, Thon-Gutschi E, Stojakovic T, Manninger M, Scherr D, Scharnagl H, Kapl M, Pieske B, Heinzel FR. | 01/13/2018 |
| Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented. | Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2.
Tao Y, Zhong C, Zhu J, Xu S, Ding J., Free PMC Article | 09/23/2017 |
| Reduced BRD1 expression is associated with Schizophrenia. | DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.
Dyrvig M, Qvist P, Lichota J, Larsen K, Nyegaard M, Børglum AD, Christensen JH., Free PMC Article | 08/19/2017 |
| Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders. | Identification of the BRD1 interaction network and its impact on mental disorder risk.
Fryland T, Christensen JH, Pallesen J, Mattheisen M, Palmfeldt J, Bak M, Grove J, Demontis D, Blechingberg J, Ooi HS, Nyegaard M, Hauberg ME, Tommerup N, Gregersen N, Mors O, Corydon TJ, Nielsen AL, Børglum AD., Free PMC Article | 02/25/2017 |
| The PHD finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface. | Solution structure of an atypical PHD finger in BRPF2 and its interaction with DNA.
Liu L, Qin S, Zhang J, Ji P, Shi Y, Wu J. | 02/23/2013 |
| Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). | Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).
Qin S, Jin L, Zhang J, Liu L, Ji P, Wu M, Wu J, Shi Y., Free PMC Article | 12/10/2011 |
| BRD1 may have a role in schizophrenia and bipolar affective disorder | Support of association between BRD1 and both schizophrenia and bipolar affective disorder.
Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD, Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD. | 01/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The association of BRD1 with schizophrenia in a Japanese population, was analysed. | Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population.
Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N, Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N. | 06/28/2010 |
| These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease. | Further immunohistochemical characterization of BRD1 a new susceptibility gene for schizophrenia and bipolar affective disorder.
Bjarkam CR, Corydon TJ, Olsen IM, Pallesen J, Nyegaard M, Fryland T, Mors O, Børglum AD. | 04/12/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation study of bromodomain-containing 1 gene with schizophrenia in Japanese population.
Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N, Kushima I, Aleksic B, Ikeda M, Yamanouchi Y, Kinoshita Y, Ito Y, Nakamura Y, Inada T, Iwata N, Ozaki N. Support of association between BRD1 and both schizophrenia and bipolar affective disorder.
Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD, Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD. | 09/16/2009 |