| Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma. | Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.
Wu Q, Li X, Long M, Xie X, Liu Q., Free PMC Article | 11/3/2023 |
| ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1. | ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1.
Zhong W, Cao X, Pan G, Niu Q, Feng X, Xu M, Li M, Huang Y, Yi Q, Yan D., Free PMC Article | 03/5/2022 |
| ORP4L is a cofactor of ITPR1. | ORP4L couples IP(3) to ITPR1 in control of endoplasmic reticulum calcium release.
Cao X, Chen J, Li D, Xie P, Xu M, Lin W, Li S, Pan G, Tang Y, Xu J, Olkkonen VM, Yan D, Zhong W. | 06/13/2020 |
| ORP4L interacts with the trans-Golgi networt in an sterol- and phosphatidylinositol 4-phosphate -dependent manner. | Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding.
Pietrangelo A, Ridgway ND. | 10/26/2019 |
| This study reveals detailed mechanistic insight into the role of ORP4L in PLCbeta3 redistribution from storage within the nucleus to the plasma membrane via RAN activation and interaction with VAPA in Jurkat T-cells. | OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells.
Pan G, Cao X, Liu B, Li C, Li D, Zheng J, Lai C, Olkkonen VM, Zhong W, Yan D., Free PMC Article | 03/23/2019 |
| The authors uncovered a signalling pathway operating specifically in T-cell acute lymphoblastic leukemia cells in which ORP4L mediates G protein-coupled ligand-induced PLCbeta3 activation, resulting in an increase of mitochondrial respiration for cell survival. | ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.
Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D., Free PMC Article | 09/8/2018 |
| High ORP4L expression is associated with cervical carcinoma. | Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.
Li JW, Xiao YL, Lai CF, Lou N, Ma HL, Zhu BY, Zhong WB, Yan DG., Free PMC Article | 03/17/2018 |
| ORP4L is crucial for macrophage survival and plays a role in the development of atherosclerosis. | ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis.
Zhong W, Pan G, Wang L, Li S, Ou J, Xu M, Li J, Zhu B, Cao X, Ma H, Li C, Xu J, Olkkonen VM, Staels B, Yan D. | 05/6/2017 |
| ORP4 promotes the survival of rapidly proliferating cells. | Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival.
Charman M, Colbourne TR, Pietrangelo A, Kreplak L, Ridgway ND., Free PMC Article | 10/11/2014 |
| Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation. | Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation.
Park IW, Ndjomou J, Wen Y, Liu Z, Ridgway ND, Kao CC, He JJ., Free PMC Article | 06/21/2014 |
| In preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from cholangiocarcinoma patients than in healthy controls. | Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
Loilome W, Wechagama P, Namwat N, Jusakul A, Sripa B, Miwa M, Kuver R, Yongvanit P. | 04/7/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| a possible role of OSBP2 gene in the pathogenesis of oxidative damage to the macula induced by oxysterols in age-related macular degeneration patients. | Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration.
Torrini M, Marchese C, Vanzetti M, Marini V, Origone P, Garré C, Mareni C, Torrini M, Marchese C, Vanzetti M, Marini V, Origone P, Garré C, Mareni C. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Mutation analysis of oxisterol-binding-protein gene in patients with age-related macular degeneration.
Torrini M, Marchese C, Vanzetti M, Marini V, Origone P, Garré C, Mareni C, Torrini M, Marchese C, Vanzetti M, Marini V, Origone P, Garré C, Mareni C. | 04/3/2008 |
| Thus the sterol-binding domain of ORP4 binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network. | Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization.
Wyles JP, Perry RJ, Ridgway ND. | 01/21/2010 |
| OSBP2 has a role in chronic myeloid leukemia | HLM/OSBP2 is expressed in chronic myeloid leukemia.
Henriques Silva N, Vasconcellos Fournier M, Pimenta G, Pulcheri WA, Spector N, da Costa Carvalho Mda G. | 01/21/2010 |