| Association of Maternal Betaine-Homocysteine Methyltransferase (BHMT) and BHMT2 Genes Polymorphisms with Congenital Heart Disease in Offspring. | Association of Maternal Betaine-Homocysteine Methyltransferase (BHMT) and BHMT2 Genes Polymorphisms with Congenital Heart Disease in Offspring.
Luo M, Wang T, Huang P, Zhang S, Song X, Sun M, Liu Y, Wei J, Shu J, Zhong T, Chen Q, Zhu P, Qin J. | 01/14/2023 |
| Our study suggested markers in BHMT/BHMT2 and DMGDH might affect the risk of NSCL/P through pairwise interaction. | Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.
Wang P, Wu T, Schwender H, Wang H, Shi B, Wang ZQ, Yuan Y, Liu DJ, Wang MY, Li J, Zhou ZB, Zhu HP, Beaty TH. | 11/10/2018 |
| A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 and GPX3 contribute to congenital heart defects | A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects.
Li M, Li J, Wei C, Lu Q, Tang X, Erickson SW, MacLeod SL, Hobbs CA., Free PMC Article | 06/4/2016 |
| The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT. | Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.
Ganu RS, Ishida Y, Koutmos M, Kolokotronis SO, Roca AL, Garrow TA, Schook LB., Free PMC Article | 05/7/2016 |
| Multiple SNPs in BHMT and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements. | Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.
Tang X, Cleves MA, Nick TG, Li M, MacLeod SL, Erickson SW, Li J, Shaw GM, Mosley BS, Hobbs CA, National Birth Defects Prevention Study., Free PMC Article | 02/20/2016 |
| No significant level of association was found with cleft lip with or without cleft palate and BHMT2 variants. | New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.
Martinelli M, Masiero E, Carinci F, Morselli PG, Pezzetti F, Scapoli L. | 10/15/2011 |
| gene-gene interaction analysis revealed a significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility. | Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP, Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP. | 12/11/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | See all PubMed (2) articlesPolymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.
Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP, Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP. Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.
Mostowska A, Hozyasz KK, Wojcicki P, Dziegelewska M, Jagodzinski PP. | 09/20/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.
Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT., Free PMC Article | 01/11/2009 |
| Common genetic variation in BHMT and BHMT2 and functionally characterized BHMT SNPs. | Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.
Li F, Feng Q, Lee C, Wang S, Pelleymounter LL, Moon I, Eckloff BW, Wieben ED, Schaid DJ, Yee V, Weinshilboum RM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Giusti B, Saracini C, Bolli P, Magi A, Martinelli I, Peyvandi F, Rasura M, Volpe M, Lotta LA, Rubattu S, Mannucci PM, Abbate R. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
Shaw GM, Lu W, Zhu H, Yang W, Briggs FB, Carmichael SL, Barcellos LF, Lammer EJ, Finnell RH. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.
Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, Pratesi G, Pulli R, Pratesi C, Abbate R. | 07/30/2008 |
| Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. | Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.
Szegedi SS, Castro CC, Koutmos M, Garrow TA., Free PMC Article | 01/21/2010 |
| Observational study of genetic testing. (HuGE Navigator) | High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.
Giusti B, Sestini I, Saracini C, Sticchi E, Bolli P, Magi A, Gori AM, Marcucci R, Gensini GF, Abbate R. | 05/11/2008 |
| Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism. | Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.
Weisberg IS, Park E, Ballman KV, Berger P, Nunn M, Suh DS, Breksa AP 3rd, Garrow TA, Rozen R. | 01/21/2010 |