| GLRA2 gene mutations cause high myopia in humans and mice. | GLRA2 gene mutations cause high myopia in humans and mice.
Tian Q, Tong P, Chen G, Deng M, Cai T, Tian R, Zhang Z, Xia K, Hu Z., Free PMC Article | 01/28/2023 |
| T258F gain of function mutation in cerebellar granule cells modifies single-cell and neural network signaling. | The role of tonic glycinergic conductance in cerebellar granule cell signalling and the effect of gain-of-function mutation.
McLaughlin C, Clements J, Oprişoreanu AM, Sylantyev S., Free PMC Article | 07/18/2020 |
| alpha2 and alpha3 GlyRs are present in various regions of the forebrain and that alpha3 GlyRs specifically participate in tonic inhibition in the striatum and prefrontal cortex. | Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.
McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL., Free PMC Article | 07/28/2018 |
| These results, which reveal neurodevelopmental roles for alpha2-GlyRs in the adult brain, may be clinically relevant, given that a mutation in GLAR2, as well as Adult hippocampal neurogenesis impairments. | α2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory.
Lin MS, Xiong WC, Li SJ, Gong Z, Cao X, Kuang XJ, Zhang Y, Gao TM, Mechawar N, Liu C, Zhu XH. | 02/3/2018 |
| Findings show that the loss of embryonic GlyRalpha2 ultimately impairs the formation of cortical circuits in the mature brain; results demonstrate a physiological role for alpha2 GlyRs during cortical network formation and homeostasis | Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors.
Morelli G, Avila A, Ravanidis S, Aourz N, Neve RL, Smolders I, Harvey RJ, Rigo JM, Nguyen L, Brône B. | 05/6/2017 |
| genetic inactivation of Glra2, the gene coding the alpha2 subunit of GlyRs, disrupts dorsal cortical progenitor homeostasis with an impaired capability of apical progenitors to generate basal progenitors. | Glycine receptors control the generation of projection neurons in the developing cerebral cortex.
Avila A, Vidal PM, Tielens S, Morelli G, Laguesse S, Harvey RJ, Rigo JM, Nguyen L., Free PMC Article | 06/27/2015 |
| Endogenous activation of Glra2 promotes neuronal migration by regulating nucleokinesis. | Glycine receptor α2 subunit activation promotes cortical interneuron migration.
Avila A, Vidal PM, Dear TN, Harvey RJ, Rigo JM, Nguyen L., Free PMC Article | 03/15/2014 |
| The distinct developmental regulation of GlyRalpha2 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation. | Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.
Buerbank S, Becker K, Becker CM, Brandt N, Engel J, Knipper M, Schick B, Dlugaiczyk J. | 05/19/2012 |
| Findings are the first to define GlyR subunit-specific control of visual function and GlyRalpha2 subunit-specific control of crossover inhibition in the retina. | Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.
Nobles RD, Zhang C, Müller U, Betz H, McCall MA., Free PMC Article | 04/28/2012 |
| Glycine receptors (GlyRs) of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit. | Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
Majumdar S, Weiss J, Wässle H., Free PMC Article | 01/21/2010 |
| Glycinergic sIPSCs of amacrine cells had slow kinetics (tau=27+/-6.8 ms) that were significantly prolonged in Glra2-/- mice (tau=69+/-16 ms). | Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.
Weiss J, O'Sullivan GA, Heinze L, Chen HX, Betz H, Wässle H. | 01/21/2010 |
| Data suggest that GlyRalpha2, the developmentally expressed glycine receptor, may play an important role in neuronal development. | Characterization of mice with targeted deletion of glycine receptor alpha 2.
Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL., Free PMC Article | 01/21/2010 |