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    PRKD3 protein kinase D3 [ Homo sapiens (human) ]

    Gene ID: 23683, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration.

    Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration.
    Varga A, Nguyen MT, Pénzes K, Bátai B, Gyulavári P, Gurbi B, Murányi J, Csermely P, Csala M, Vántus T, Sőti C., Free PMC Article

    02/11/2023
    PRKD3 promotes malignant progression of OSCC by downregulating KLF16 expression.

    PRKD3 promotes malignant progression of OSCC by downregulating KLF16 expression.
    Chen Z, Huang Q, Xu W, Wang H, Yang J, Zhang LJ.

    07/3/2021
    Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.

    Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice.
    Zhang S, Liu H, Yin M, Pei X, Hausser A, Ishikawa E, Yamasaki S, Jin ZG., Free PMC Article

    05/8/2021
    Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c-MYC axis in breast cancer.

    Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c-MYC axis in breast cancer.
    Liu Y, Song H, Yu S, Huang KH, Ma X, Zhou Y, Yu S, Zhang J, Chen L., Free PMC Article

    05/1/2021
    The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells.

    The GEF-H1/PKD3 signaling pathway promotes the maintenance of triple-negative breast cancer stem cells.
    Lieb WS, Lungu C, Tamas R, Berreth H, Rathert P, Storz P, Olayioye MA, Hausser A., Free PMC Article

    03/13/2021
    Protein kinase D3 regulates the expression of the immunosuppressive protein, PDL1, through STAT1/STAT3 signaling.

    Protein kinase D3 regulates the expression of the immunosuppressive protein, PD‑L1, through STAT1/STAT3 signaling.
    Cui B, Chen J, Luo M, Wang L, Chen H, Kang Y, Wang J, Zhou X, Feng Y, Zhang P., Free PMC Article

    02/20/2021
    The PRKD3 up-regulated 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and activated glycolysis as shown by increased glucose consumption and lactate production.

    Protein kinase D3 promotes gastric cancer development through p65/6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 activation of glycolysis.
    Zhang J, Zhang Y, Wang J, Zhang S, Zhao Y, Ren H, Chu Y, Feng L, Wang C.

    07/4/2020
    KD2 and PKD3 were the two major isoforms of PKD overexpressed in breast cancer. Suppressing either PKD2 or PKD3 was able to reduce breast cancer cell proliferation and metastasis.

    Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.
    Liu Y, Li J, Ma Z, Zhang J, Wang Y, Yu Z, Lin X, Xu Z, Su Q, An L, Zhou Y, Ma X, Yang Y, Wang F, Chen Q, Zhang Y, Wang J, Zheng H, Shi A, Yu S, Zhang J, Zhao W, Chen L., Free PMC Article

    03/28/2020
    exogenous SCF, CCL5 and CCL11 reversed the effect on MCs migration inhibited by PKD2/3 silencing. Mechanistically, PKD2/3 interacted with Erk1/2 and activated Erk1/2 or NF-kappaB signaling pathway, leading to AP-1 or NF-kappaB binding to the promoter of scf, ccl5 and ccl11.

    Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.
    Xu W, Qian J, Zeng F, Li S, Guo W, Chen L, Li G, Zhang Z, Wang QJ, Deng F., Free PMC Article

    06/22/2019
    Our findings suggest that abnormal PKD3 expression might contribute to hepatocellular carcinoma progression. Furthermore, high PKD3 expression predicts a poor prognosis in hepatocellular carcinoma patients after hepatectomy

    Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients.
    Yang H, Xu M, Chi X, Yan Q, Wang Y, Xu W, Zhuang K, Li A, Liu S.

    07/7/2018
    The enriched pathway analysis reveals that PRKD3 regulates pathways contributing to multiple cancer related events, including cell cycle, migration and others.

    Oncogenic Protein Kinase D3 Regulating Networks in Invasive Breast Cancer.
    Liu Y, Li J, Zhang J, Yu Z, Yu S, Wu L, Wang Y, Gong X, Wu C, Cai X, Mo L, Wang M, Gu J, Chen L., Free PMC Article

    04/7/2018
    None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 genes.

    Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.
    Piscuoglio S, Fusco N, Ng CK, Martelotto LG, da Cruz Paula A, Katabi N, Rubin BP, Skálová A, Weinreb I, Weigelt B, Reis-Filho JS., Free PMC Article

    11/4/2017
    This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1, PKD2, and PKD3 monomers.

    A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.
    Aicart-Ramos C, He SD, Land M, Rubin CS., Free PMC Article

    06/3/2017
    Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 and upregulated PKD3 to be positive regulators of proliferation.

    Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.
    Durand N, Borges S, Storz P., Free PMC Article

    04/2/2016
    Loss of PKD2 enhanced KC proliferative potential while loss of PKD3 resulted in a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability.

    Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.
    Ryvkin V, Rashel M, Gaddapara T, Ghazizadeh S., Free PMC Article

    07/4/2015
    for the first time, PKD3 is implicated in the transcription activation of latent HIV-1 provirus, and our results revealed a molecular mechanism of prostratin-induced HIV-1 transcription via PKCepsilon/PKD3/NF-kappaB signaling pathway.

    Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway.
    Wang H, Zhu X, Zhu Y, Liu J, Hu X, Wang Y, Peng S, Chen Y, Chen R, Ding F, Liu R., Free PMC Article

    05/16/2015
    Activation of PKD2 and further increase of PKD3 activity leads to additional phosphorylation and inhibition of endogenous phosphatase slingshot 1L.

    Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.
    Döppler H, Bastea LI, Borges S, Spratley SJ, Pearce SE, Storz P., Free PMC Article

    01/10/2015
    PKD3 in TNBC cells provides a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTORC1-S6K1 signaling.

    Elevated protein kinase D3 (PKD3) expression supports proliferation of triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation.
    Huck B, Duss S, Hausser A, Olayioye MA., Free PMC Article

    04/12/2014
    PKD3 negatively regulates human airway epithelial barrier formation and integrity through down-regulation of claudin-1, which is a key component of tight junctions.

    Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1.
    Gan H, Wang G, Hao Q, Wang QJ, Tang H., Free PMC Article

    02/22/2014
    PKD3 contributes to the proliferation and malignant growth of androgen-dependent prostate cancer cells in part by upregulating PSA expression.

    [PKD3 contributes to up-regulation of prostate-specific antigen in prostate cancer cells].
    Deng F, Wang CX, Xu WF, Feng L, Ke ZY, Wang QJ, Zou ZP.

    06/29/2013
    PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 expression.

    [Protein kinase D3 is involved in negative regulation of MMP-7 in prostate cancer cells].
    Zou ZP, Feng L, Xu WF, Ke ZY, Wang QJ, Deng F.

    06/29/2013
    We have identified PKD2 and PKD3, especially PKD3, as novel cell growth regulators in HCC1806 triple-negative breast cancer cells

    Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.
    Hao Q, McKenzie R, Gan H, Tang H.

    04/13/2013
    PKD antagonists inhibited differentiation and viability of human hematopoietic stem cells, and had less HDAC phosphorylation, confirming the need for PKD-HDAC signaling in erythropoiesis.

    Protein kinase D-HDAC5 signaling regulates erythropoiesis and contributes to erythropoietin cross-talk with GATA1.
    Delehanty LL, Bullock GC, Goldfarb AN., Free PMC Article

    01/26/2013
    phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin trafficking, and cellular protrusive activity are regulated.

    GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity.
    Huck B, Kemkemer R, Franz-Wachtel M, Macek B, Hausser A, Olayioye MA., Free PMC Article

    01/5/2013
    Data demonstrate the functional role of protein kinase D1 and protein kinase D3 in modulating physiological responses to Ox1R activation.

    A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.
    Peltonen HM, Akerman KE, Bart G.

    10/30/2010
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