| Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target. | Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target.
Ferrari MG, Jimenez-Uribe AP, Wang L, Hoeppner LH, Murugan P, Hahm E, Yu J, Kuzel TM, Gradilone SA, Mansini AP., Free PMC Article | 02/20/2024 |
| Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2. | Insights into the molecular basis and mechanism of heme-triggered TLR4 signalling: The role of heme-binding motifs in TLR4 and MD2.
Hopp MT, Holze J, Lauber F, Holtkamp L, Rathod DC, Miteva MA, Prestes EB, Geyer M, Manoury B, Merle NS, Roumenina LT, Bozza MT, Weindl G, Imhof D. | 01/30/2024 |
| Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy. | Myeloid differentiation factor-2 activates monocytes in patients with dilated cardiomyopathy.
Feldtmann R, Kümmel A, Chamling B, Strohbach A, Lehnert K, Gross S, Loerzer L, Riad A, Lindner D, Westermann D, Fielitz J, Dörr M, Felix SB. | 08/20/2022 |
| Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. | Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells.
Zhang P, Nguyen J, Abdulla F, Nelson AT, Beckman JD, Vercellotti GM, Belcher JD., Free PMC Article | 09/18/2021 |
| Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. | Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling.
Huang S, You S, Qian J, Dai C, Shen S, Wang J, Huang W, Liang G, Wu G., Free PMC Article | 08/21/2021 |
| HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-kappaB dependent pathway. | HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway.
Bahraoui E, Serrero M, Planès R., Free PMC Article | 12/19/2020 |
| MD2 protein is highly expressed and involved in the occurrence and development of inflammatory bowel disease, and plays an important role in mucosal barrier injury. | The effects and mechanisms of myeloid differentiation protein 2 on intestinal mucosal permeability in mice with chronic colitis.
Han C, Guan Q, Guo L, Yang Y, Ruan S, Zhang X. | 06/6/2020 |
| The data show that mice expressing humanTLR4/ human MD-2 are slightly more susceptible to C. burnetii infection at some intervals than those expressing mouse TLR4. | Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection.
Robison A, Snyder DT, Christensen K, Kimmel E, Hajjar AM, Jutila MA, Hedges JF., Free PMC Article | 04/18/2020 |
| The lipid A modifications present in LPS 430 and LPS 435 have a moderate effect on the activation of the human TLR4/MD-2 complex. | Structural variants of Salmonella Typhimurium lipopolysaccharide induce less dimerization of TLR4/MD-2 and reduced pro-inflammatory cytokine production in human monocytes.
Aldapa-Vega G, Moreno-Eutimio MA, Berlanga-Taylor AJ, Jiménez-Uribe AP, Nieto-Velazquez G, López-Ortega O, Mancilla-Herrera I, Cortés-Malagón EM, Gunn JS, Isibasi A, Wong-Baeza I, López-Macías C, Pastelin-Palacios R. | 11/2/2019 |
| Viable CD14/TLR4/MD-2 oligomers were assembled at the plasma membrane surface, and lipopolysaccharide exchange was observed between CD14 and TLR4/MD-2. | A Thermodynamic Funnel Drives Bacterial Lipopolysaccharide Transfer in the TLR4 Pathway.
Huber RG, Berglund NA, Kargas V, Marzinek JK, Holdbrook DA, Khalid S, Piggot TJ, Schmidtchen A, Bond PJ. | 08/10/2019 |
| These results show that isofraxidin binds to and inhibits MD-2, thus preventing TLR4/MD-2 complex formation without altering TLR2 signalling. We demonstrated that isofraxidin promoted cell proliferation and inhibited the lipopolysaccharide induced inflammatory response through suppressing the activation of the TLR4/MD-2 axis and NF-kappaB signalling in human osteoarthritis chondrocytes. | Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.
Jin J , Yu X , Hu Z , Tang S , Zhong X , Xu J , Shang P , Huang Y , Liu H . | 03/30/2019 |
| An increase of MD-2 expression levels was associated with an absolute mortality risk increase in dilated cardiomyopathy patients. | MD-2 is a new predictive biomarker in dilated cardiomyopathy and exerts direct effects in isolated cardiomyocytes.
Riad A, Gross S, Witte J, Feldtmann R, Wagner KB, Reinke Y, Weitmann K, Empen K, Beug D, Westermann D, Lindner D, Klingel K, Dörr M, Hoffmann W, Felix SB. | 03/16/2019 |
| sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness in vitro and in vivo by lncRNA H19 down-regulation. | sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness in vitro and in vivo by lncRNA H19 down-regulation.
Liang W, Zou Y, Qin F, Chen J, Xu J, Huang S, Chen J, Dai S. | 05/19/2018 |
| MD-2 siRNA or plasmid further confirmed the efficacy of Iturin A by suppressing MD-2/TLR4 signaling pathway. The in silico docking study showed that the Iturin A interacted well with the MD-2 in MD-2/TLR4 receptor complex. Conclusively, inhibition of MD-2/TLR4 complex with Iturin A offered strategic advancement in cancer therapy. | Therapeutic implication of 'Iturin A' for targeting MD-2/TLR4 complex to overcome angiogenesis and invasion.
Dey G, Bharti R, Ojha PK, Pal I, Rajesh Y, Banerjee I, Banik P, Parida S, Parekh A, Sen R, Mandal M. | 02/24/2018 |
| data confirm that engineered human cells expressing TLR4, MD2 and CD14 can respond to CMP with NF-kappaB activation and the response can be influenced by variations in CMP-mannosylation | Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.
Ness T, Abdallah M, Adams J, Alvarado C, Gunn E, House B, Lamb J, Macguire J, Norris E, Robinson R, Sapp M, Sharma J, Garner R., Free PMC Article | 02/10/2018 |
| The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88/NF-kappaB signaling. | MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line.
Luo M, Hu L, Li D, Wang Y, He Y, Zhu L, Ren W. | 11/11/2017 |
| MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases. | Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.
Hosoki K, Boldogh I, Aguilera-Aguirre L, Sun Q, Itazawa T, Hazra T, Brasier AR, Kurosky A, Sur S., Free PMC Article | 06/24/2017 |
| we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 | Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4.
Yang J, Qin N, Zhang H, Yang R, Xiang B, Wei Q., Free PMC Article | 03/11/2017 |
| In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified. | Identification of a novel transcript of human MD2 gene.
Shen C, Shen AD. | 01/28/2017 |
| Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 signaling. | MD2 expression is reduced in large airways of smokers and COPD smokers.
Pace E, Ferraro M, Chiappara G, Vitulo P, Pipitone L, Di Vincenzo S, Gjomarkaj M. | 06/4/2016 |
| Predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation. | MD-2 determinants of nickel and cobalt-mediated activation of human TLR4.
Oblak A, Pohar J, Jerala R., Free PMC Article | 02/27/2016 |
| The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 ligands may be facilitated through synthesis and release of sMD2 by the amniochorion. | Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA., Free PMC Article | 02/13/2016 |
| Three genes (LY96, IL8 DPR) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8). | A genomic profile of the immune response to stroke with implications for stroke recovery.
Barr TL, VanGilder R, Rellick S, Brooks SD, Doll DN, Lucke-Wold AN, Chen D, Denvir J, Warach S, Singleton A, Matarin M. | 02/6/2016 |
| The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4. | Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.
Mattis DM, Chervin AS, Ranoa DR, Kelley SL, Tapping RI, Kranz DM., Free PMC Article | 01/30/2016 |
| Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. | Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.
Zhou W, Yuan W, Huang L, Wang P, Rong X, Tang J., Free PMC Article | 01/2/2016 |