| KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity. | KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity.
Yu M, Sun L, Zhang Z, Zhang Y, Zhang H, Na L, Wang X., Free PMC Article | 03/19/2022 |
| Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 A resolution. | Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution.
Tsimbalyuk S, Donnelly CM, Forwood JK., Free PMC Article | 02/26/2022 |
| HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions. | HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions.
Fareed FMA, Korulu S, Özbil M, Çapan ÖY. | 12/25/2021 |
| Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for KPNA2, KPNA4 and KPNA6 proteins. | Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.
Major AT, Miyamoto Y, Lo CY, Jans DA, Loveland KL., Free PMC Article | 11/3/2018 |
| the data showed that viral infection induced an elevation of the KPNA6 protein level due to an extension of the KPNA6 half-life via viral interference of the ubiquitin-proteasomal degradation of KPNA6. Notably, KPNA6 silencing or knockout dramatically reduced the replication of PRRSV and ZIKV. | Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus.
Yang L, Wang R, Yang S, Ma Z, Lin S, Nan Y, Li Q, Tang Q, Zhang YJ., Free PMC Article | 05/19/2018 |
| a decreased H7N9 influenza A virus polymerase activity when importin-alpha7 was silenced by siRNA, is reported. | H7N9 Influenza A Virus Exhibits Importin-α7-Mediated Replication in the Mammalian Respiratory Tract.
Bertram S, Thiele S, Dreier C, Resa-Infante P, Preuß A, van Riel D, Mok CKP, Schwalm F, Peiris JSM, Klenk HD, Gabriel G. | 05/27/2017 |
| BIG3 may block the KPNAs (KPNA1, KPNA5, and KPNA6) binding region(s) of PHB2. | BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.
Kim NH, Yoshimaru T, Chen YA, Matsuo T, Komatsu M, Miyoshi Y, Tanaka E, Sasa M, Mizuguchi K, Katagiri T., Free PMC Article | 03/5/2016 |
| Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. | [Identification of prototype foamy virus Bel1 nuclear localization signal and its corresponding importins].
Ma QL, Yu M, Luo D, Tan J, Qiao WT. | 11/8/2014 |
| Importin alpha1 and alpha7 are positive regulators of human-like polymerase activity and pathogenicity beyond their role in nuclear transport. | Human-like PB2 627K influenza virus polymerase activity is regulated by importin-α1 and -α7.
Hudjetz B, Gabriel G., Free PMC Article | 06/28/2014 |
| Overexpression of KPNA6 facilitates KEAP1 nuclear import and attenuates NRF2 signaling, whereas knockdown of KPNA6 slows down KEAP1 nuclear import and enhances the NRF2-mediated adaptive response induced by oxidative stress. | KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD., Free PMC Article | 06/18/2011 |
| Importin alpha5 and alpha7 bind to Stat3 upon cytokine stimulation. | Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements.
Ma J, Cao X. | 01/21/2010 |