| CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A. | CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A.
Hu J, Li X, Xu K, Chen J, Zong S, Zhang H, Li H, Zhang G, Guo Z, Zhao X, Jiang Y, Jing Z. | 09/4/2024 |
| MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression. | MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression.
Dong X, Zhan Y, Li S, Yang M, Gao Y., Free PMC Article | 03/15/2024 |
| MKRN1 promotes colorectal cancer metastasis by activating the TGF-beta signalling pathway through SNIP1 protein degradation. | MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation.
Zhang Y, Li QS, Liu HL, Tang HT, Yang HL, Wu DQ, Huang YY, Li LC, Liu LH, Li MX., Free PMC Article | 09/1/2023 |
| MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53. | MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53.
Yang Y, Luo Y, Huang S, Tao Y, Li C, Wang C. | 04/14/2023 |
| Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls. | Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.
Torrence D, Xie Z, Zhang L, Chi P, Antonescu CR., Free PMC Article | 03/19/2022 |
| directly binds to the cytoplasmic poly(A)-binding protein; mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts | The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger JB, Busch A, Hänel H, Voigt A, Möckel MM, Ebersberger S, Scholz A, Dold A, Schmid T, Ebersberger I, Roignant JY, Zarnack K, König J, Beli P., Free PMC Article | 01/4/2020 |
| MKRN1 functions as a novel E3 ligase of APC that positively regulates Wnt/beta-catenin-mediated biological processes. | Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling.
Lee HK, Lee EW, Seo J, Jeong M, Lee SH, Kim SY, Jho EH, Choi CH, Chung JY, Song J. | 02/23/2019 |
| HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. | Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.
Inturi R, Mun K, Singethan K, Schreiner S, Punga T., Free PMC Article | 04/21/2018 |
| In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening. | Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology.
Lee M, Chang MY, Shin HY, Shin E, Hong SW, Kim KM, Chay DB, Cho H, Kim JH., Free PMC Article | 06/11/2016 |
| EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase. | PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
Lee MS, Jeong MH, Lee HW, Han HJ, Ko A, Hewitt SM, Kim JH, Chun KH, Chung JY, Lee C, Cho H, Song J., Free PMC Article | 04/16/2016 |
| Results verified MKRN1 as an ubiquitin E3 ligase of p14ARF, it potentially regulates cellular aging and tumorigenesis in gastric cancer. | Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.
Ko A, Shin JY, Seo J, Lee KD, Lee EW, Lee MS, Lee HW, Choi IJ, Jeong JS, Chun KH, Song J., Free PMC Article | 01/12/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| MKRN1 could induce WNV capsid protein ubiquitination and degradation in a proteasome-dependent manner | MKRN1 induces degradation of West Nile virus capsid protein by functioning as an E3 ligase.
Ko A, Lee EW, Yeh JY, Yang MR, Oh W, Moon JS, Song J., Free PMC Article | 01/25/2010 |
| Makorin 1 is a novel SEREX antigen of esophageal squamous cell carcinoma | Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.
Shimada H, Shiratori T, Yasuraoka M, Kagaya A, Kuboshima M, Nomura F, Takiguchi M, Ochiai T, Matsubara H, Hiwasa T., Free PMC Article | 01/21/2010 |
| Data indicate that MKRN1 is a novel modulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. | Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.
Lee EW, Lee MS, Camus S, Ghim J, Yang MR, Oh W, Ha NC, Lane DP, Song J., Free PMC Article | 01/21/2010 |
| MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription. | Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription.
Omwancha J, Zhou XF, Chen SY, Baslan T, Fisher CJ, Zheng Z, Cai C, Shemshedini L. | 01/21/2010 |